Definition
Adenocarcinoma in situ (AIS) is a localized lesion showing a pure lepidic (bronchioloalveolar) growth pattern of adenocarcinoma cells lining preexisting alveolar walls, with no evidence of stromal, lymphatic, or pleural invasion. Lesions are generally less than 30 mm, and often less than 20 mm, in diameter, although size is not a limitation to diagnosis per se (Figs. 1, 2, 3, 4, 5, 6, 7, and 8).
This lesion visible on the lung cut surface measured about 8 mm in maximum dimension. Despite showing a collapsed center with a more solid appearance, there was no evidence of invasive disease
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References and Further Reading
Kerr, K. M. (2013). Pulmonary preinvasive disease. In P. Hasleton & D. B. Flieder (Eds.), Spencer’s pathology of the lung (6th ed., pp. 889–944). New York: Cambridge University Press.
Qiu, Z. X., Cheng, Y., Liu, D., et al. (2016). Clinical, pathological, and radiological characteristics of solitary ground-glass opacity lung nodules on high-resolution computed tomography. Therapeutics and Clinical Risk Management, 12, 1445–1453.
Selamat, S. A., Galler, J. S., Joshi, A. D., et al. (2011). DNA methylation changes in atypical adenomatous hyperplasia, adenocarcinoma in situ, and lung adenocarcinoma. PloS One, 6(6), e21443.
Travis, W. D., Brambilla, E., Noguchi, M., et al. (2011). International association for the study of lung cancer/American thoracic society/European respiratory society international multidisciplinary classification of lung adenocarcinoma. Journal of Thoracic Oncology, 6(2), 244–285.
Travis, W. D, Brambilla, E., & Noguchi, M., et al. (2012). Diagnosis of lung adenocarcinoma in resected specimens: Implications of the 2011 international association for the Study of Lung Cancer/American Thoracic Society/European Respiratory Society Classification. Arch Pathol Lab Med. 2013 May;137(5):685–705.
Travis, W. D., Brambilla, E., Burke, A. P., Marx, A., & Nicholson, A. N. (Eds.). (2015). WHO classification of tumours of the lung, pleura, thymus and heart. Geneva: WHO Press.
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Kerr, K.M., Chapman, A.D. (2017). Adenocarcinoma In Situ. In: van Krieken, J. (eds) Encyclopedia of Pathology. Encyclopedia of Pathology. Springer, Cham. https://doi.org/10.1007/978-3-319-28845-1_4308-1
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DOI: https://doi.org/10.1007/978-3-319-28845-1_4308-1
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