Encyclopedia of Pathology

Living Edition
| Editors: J.H.J.M. van Krieken

Adenocarcinoma In Situ

  • Keith M. KerrEmail author
  • Andrea D. Chapman
Living reference work entry
DOI: https://doi.org/10.1007/978-3-319-28845-1_4308-1



Adenocarcinoma in situ (AIS) is a localized lesion showing a pure lepidic (bronchioloalveolar) growth pattern of adenocarcinoma cells lining preexisting alveolar walls, with no evidence of stromal, lymphatic, or pleural invasion. Lesions are generally less than 30 mm, and often less than 20 mm, in diameter, although size is not a limitation to diagnosis per se (Figs. 1, 2, 3, 4, 5, 6, 7, and 8).
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References and Further Reading

  1. Kerr, K. M. (2013). Pulmonary preinvasive disease. In P. Hasleton & D. B. Flieder (Eds.), Spencer’s pathology of the lung (6th ed., pp. 889–944). New York: Cambridge University Press.CrossRefGoogle Scholar
  2. Qiu, Z. X., Cheng, Y., Liu, D., et al. (2016). Clinical, pathological, and radiological characteristics of solitary ground-glass opacity lung nodules on high-resolution computed tomography. Therapeutics and Clinical Risk Management, 12, 1445–1453.CrossRefPubMedPubMedCentralGoogle Scholar
  3. Selamat, S. A., Galler, J. S., Joshi, A. D., et al. (2011). DNA methylation changes in atypical adenomatous hyperplasia, adenocarcinoma in situ, and lung adenocarcinoma. PloS One, 6(6), e21443.CrossRefPubMedPubMedCentralGoogle Scholar
  4. Travis, W. D., Brambilla, E., Noguchi, M., et al. (2011). International association for the study of lung cancer/American thoracic society/European respiratory society international multidisciplinary classification of lung adenocarcinoma. Journal of Thoracic Oncology, 6(2), 244–285.CrossRefPubMedPubMedCentralGoogle Scholar
  5. Travis, W. D, Brambilla, E., & Noguchi, M., et al. (2012). Diagnosis of lung adenocarcinoma in resected specimens: Implications of the 2011 international association for the Study of Lung Cancer/American Thoracic Society/European Respiratory Society Classification. Arch Pathol Lab Med. 2013 May;137(5):685–705.Google Scholar
  6. Travis, W. D., Brambilla, E., Burke, A. P., Marx, A., & Nicholson, A. N. (Eds.). (2015). WHO classification of tumours of the lung, pleura, thymus and heart. Geneva: WHO Press.Google Scholar

Copyright information

© Springer International Publishing AG 2017

Authors and Affiliations

  1. 1.Department of PathologyAberdeen University Medical School, Aberdeen Royal InfirmaryAberdeenUK