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Biphasic Diffuse Malignant Mesothelioma, Pleural

  • Living reference work entry
  • First Online:
Encyclopedia of Pathology

Part of the book series: Encyclopedia of Pathology ((EP))

  • 82 Accesses

Synonyms

Biphasic diffuse malignant mesothelioma; Biphasic/mixed DMM; Mixed diffuse malignant mesothelioma

Definition

Diffuse malignant mesothelioma (DMM) is an aggressive neoplasm of the pleura, usually in individuals with history of asbestos exposure. MM is the most common primary tumor of the pleura, presenting as diffuse mass that is identifiable clinically. DMM should be distinguished from the more favorable prognosis of localized malignant mesothelioma and well-differentiated papillary malignant mesothelioma.

The 2015 World Health Organization (WHO) Classification of Tumors of the Pleura classified the major histologic types of DMM as epithelioid, sarcomatoid (desmoplastic), and biphasic mesothelioma.

Clinical Features

Incidence

Biphasic DMM is the second most common histologic variant of pleural malignant mesothelioma, accounting for 20–35% of the cases (epithelioid and sarcomatoid accounting for approximately 60% and 20% of cases, respectively).

Age

The average age at the time...

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References and Further Reading

  • Arif, Q., & Husain, A. N. (2015). Malignant mesothelioma diagnosis. Archives of Pathology and Laboratory Medicine, 139(8), 978–980. https://doi.org/10.5858/arpa.2013-0381-RA.

    Article  PubMed  Google Scholar 

  • Galateau-Salle, F., et al. (2016). The 2015 world health organization classification of tumors of the Pleura: Advances since the 2004 classification. Journal of Thoracic Oncology, 11(2), 142–154.

    Article  PubMed  Google Scholar 

  • Husain, A. N., Colby, T. V., Ordóñez, N. G., Allen, T. C., Attanoos, R. L., Beasley, M. B., Butnor, K. J., Chirieac, L. R., Churg, A. M., Dacic, S., Galateau-Sallé, F., Gibbs, A., Gown, A. M., Krausz, T., Litzky, L. A., Marchevsky, A., Nicholson, A. G., Roggli, V. L., Sharma, A. K., Travis, W. D., Walts, A. E., & Wick, M. R. (2017). Guidelines for pathologic diagnosis of malignant mesothelioma: 2017 update of the consensus statement from the international mesothelioma interest group. Archives of Pathology and Laboratory Medicine. https://doi.org/10.5858/arpa.2017-0124-RA.

  • Inai, K. (2008). Pathology of mesothelioma. Environmental Health and Preventive Medicine, 13(2), 60–64. https://doi.org/10.1007/s12199-007-0017-6.

    Article  PubMed  PubMed Central  Google Scholar 

  • Oviedo, S. P., & Cagle, P. T. (2012). Diffuse malignant mesothelioma. Archives of Pathology and Laboratory Medicine, 136(8), 882–888. https://doi.org/10.5858/arpa.2012-0142-CR.

    Article  PubMed  Google Scholar 

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Author information

Authors and Affiliations

  1. University of Texas Medical Branch in Galveston, Galveston, TX, USA

    Mohamed Khalil

  2. Department of Pathology, The University of Texas Medical Branch, Galveston, TX, USA

    Timothy Craig Allen

Authors
  1. Mohamed Khalil
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  2. Timothy Craig Allen
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Corresponding author

Correspondence to Timothy Craig Allen .

Editor information

Editors and Affiliations

  1. NIJMEGEN, The Netherlands

    J.H.J.M. van Krieken

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Khalil, M., Allen, T.C. (2018). Biphasic Diffuse Malignant Mesothelioma, Pleural. In: van Krieken, J. (eds) Encyclopedia of Pathology. Encyclopedia of Pathology. Springer, Cham. https://doi.org/10.1007/978-3-319-28845-1_4276-1

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  • DOI: https://doi.org/10.1007/978-3-319-28845-1_4276-1

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-28845-1

  • Online ISBN: 978-3-319-28845-1

  • eBook Packages: Springer Reference MedicineReference Module Medicine

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