Definition
Diffuse malignant mesothelioma (DMM) is an aggressive neoplasm of the pleura, usually in individuals with history of asbestos exposure. MM is the most common primary tumor of the pleura, presenting as diffuse mass that is identifiable clinically. DMM should be distinguished from the more favorable prognosis of localized malignant mesothelioma and well-differentiated papillary malignant mesothelioma.
The 2015 World Health Organization (WHO) Classification of Tumors of the Pleura classified the major histologic types of DMM as epithelioid, sarcomatoid (desmoplastic), and biphasic mesothelioma.
Clinical Features
Incidence
Biphasic DMM is the second most common histologic variant of pleural malignant mesothelioma, accounting for 20–35% of the cases (epithelioid and sarcomatoid accounting for approximately 60% and 20% of cases, respectively).
Age
The average age at the time...
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References and Further Reading
Arif, Q., & Husain, A. N. (2015). Malignant mesothelioma diagnosis. Archives of Pathology and Laboratory Medicine, 139(8), 978–980. https://doi.org/10.5858/arpa.2013-0381-RA.
Galateau-Salle, F., et al. (2016). The 2015 world health organization classification of tumors of the Pleura: Advances since the 2004 classification. Journal of Thoracic Oncology, 11(2), 142–154.
Husain, A. N., Colby, T. V., Ordóñez, N. G., Allen, T. C., Attanoos, R. L., Beasley, M. B., Butnor, K. J., Chirieac, L. R., Churg, A. M., Dacic, S., Galateau-Sallé, F., Gibbs, A., Gown, A. M., Krausz, T., Litzky, L. A., Marchevsky, A., Nicholson, A. G., Roggli, V. L., Sharma, A. K., Travis, W. D., Walts, A. E., & Wick, M. R. (2017). Guidelines for pathologic diagnosis of malignant mesothelioma: 2017 update of the consensus statement from the international mesothelioma interest group. Archives of Pathology and Laboratory Medicine. https://doi.org/10.5858/arpa.2017-0124-RA.
Inai, K. (2008). Pathology of mesothelioma. Environmental Health and Preventive Medicine, 13(2), 60–64. https://doi.org/10.1007/s12199-007-0017-6.
Oviedo, S. P., & Cagle, P. T. (2012). Diffuse malignant mesothelioma. Archives of Pathology and Laboratory Medicine, 136(8), 882–888. https://doi.org/10.5858/arpa.2012-0142-CR.
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Khalil, M., Allen, T.C. (2018). Biphasic Diffuse Malignant Mesothelioma, Pleural. In: van Krieken, J. (eds) Encyclopedia of Pathology. Encyclopedia of Pathology. Springer, Cham. https://doi.org/10.1007/978-3-319-28845-1_4276-1
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DOI: https://doi.org/10.1007/978-3-319-28845-1_4276-1
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