Definition
Hydroa vacciniforme (HV)-like lymphoproliferative disorder (HV-like LPD) is a chronic EBV-positive cutaneous T-cell lymphoproliferative disorder of childhood, associated with the risk of developing systemic lymphoma. HV-like LPD is a polyclonal or (most often) monoclonal disorder of T-cells and/or NK cells, regardless of the presence or absence of systemic symptoms and the severity of the skin lesions. Classic HV, severe HV, and HV-like cutaneous T-cell lymphoma constitute a continuous spectrum of EBV-associated HV-like LPD (Quintanilla-Martinezz et al. 2013, 2017).
Clinical Features
Incidence
HV-like LPD is rare and occurs mainly in children and adolescents from Latin America and East Asia. It is rare in adults. There is a seasonal increased occurrence during the summer (Quintanilla-Martinezz et al. 2013)....
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References and Further Reading
Barrionuevo, C., Anderson, V. M., Zevallos-Giampietri, E., et al. (2002). Hydroa-like cutaneous T-cell lymphoma: A clinicopathologic and molecular genetic study of 16 pediatric cases from Peru. Applied Immunohistochemistry & Molecular Morphology, 10, 7–14.
Beltran, B. E., Maza, I. N., CB, M.–. A., et al. (2014). Thalidomide for the treatment of hydroa vacciniforme-like lymphoma: Report of four pediatric cases from Peru. American Journal of Hematology, 89, 1160–1161.
Iwatsuki, K., Satoh, M., Yamamoto, T., et al. (2006). Pathogenic link between hydroa vacciniforme and Epstein-Barr virus–associated hematologic disorders. Archives of Dermatology, 142, 587–595.
Kimura, H., Ito, Y., Kawabe, S., et al. (2012). EBV-associated T/NK-cell lymphoproliferative diseases in nonimmunocompromised hosts: Prospective analysis of 108 cases. Blood, 119, 673–686.
Magana, M., Sangüeza, P., Gil-Beristain, J., et al. (1998). Angiocentric cutaneous T-cell lymphoma of childhood (hydroa-like lymphoma): A distinctive type of cutaneous T-cell lymphoma. Journal of the American Academy of Dermatology, 38, 574–579.
Miyake, T., Yamamoto, T., Hirai, Y., et al. (2015). Survival rates and prognostic factors of Epstein-Barr virus-associated hydroa vacciniforme and hypersensitivity to mosquito bites. The British Journal of Dermatology, 172(1), 56–63.
Quintanilla-Martinezz, L., Ridaura, C., Nagl, F., et al. (2013). Hydroa vacciniforme-like lymphoma: A chronic EBV+ lymphoproliferative disorder with risk to develop a systemic lymphoma. Blood, 122, 3101–3110.
Quintanilla-Martinezz L, Ko Y-H, Kimura H, et al (2017) Hydroa vacciniforme-like lymphoproliferative disorder. In S. H. Swerdlow, E. Campo, N. L. Harris, et al. (Eds.), WHO classification of Tumours of Haematopoietic and lymphoid tissues (revised 4th ed., pp. 360–362). Lyon: IARC.
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Nakazawa, A. (2019). Hydroa-Vacciniforme like Lymphoproliferative Disorder. In: van Krieken, J. (eds) Encyclopedia of Pathology. Encyclopedia of Pathology. Springer, Cham. https://doi.org/10.1007/978-3-319-28845-1_3881-1
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DOI: https://doi.org/10.1007/978-3-319-28845-1_3881-1
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