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Bone Marrow

  • Living reference work entry
  • First Online:
Encyclopedia of Pathology

Part of the book series: Encyclopedia of Pathology ((EP))

  • 188 Accesses

Synonyms

Marrow; Medulla ossium

Anatomy

Bone marrow is a semisolid tissue present in all the bones divided schematically into hematopoietically inactive fatty marrow, named yellow marrow, and hematopoietically active marrow, named red marrow. In adults, red marrow is mainly found in the central skeleton such as pelvis, sternum, skull, vertebra, scapulae, as well as epiphyseal areas of long bones such as femur and humerus.

Function

The function of hematopoietic marrow is to regulate myeloid and lymphoid cell trafficking as well as hematopoietic stem and progenitor cell maintenance for normal myelopoiesis and lymphopoiesis. In addition, the marrow contains mesenchymal stem cells that can differentiate into adipocytes, hepatocytes, osteoblasts, chondrocytes, skeletal, and cardiac muscle cells. The nonhematopoietic marrow serves as a large store of reserve lipids. Bone marrow endothelial cells form a barrier preventing entry of red blood cells and platelets from the circulation regulating...

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References and Further Reading

  • Itkin, T., Gur-Cohen, S., Spencer, J. A., Schajnovitz, A., Ramasamy, S. K., Kusumbe, A. P., Ledergor, G., Jung, Y., Milo, I., Poulos, M. G., Kalinkovich, A., Ludin, A., Kollet, O., Shakhar, G., Butler, J. M., Rafii, S., Adams, R. H., Scadden, D. T., Lin, C. P., & Lapidot, T. (2016). Distinct bone marrow blood vessels differentially regulate haematopoiesis. Nature, 532, 323–328.

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  • Kroft, S. H. (2012). Bone marrow. In S. E. Mills (Ed.), Histology for pathologists (4th ed., pp. 849–887). Philadelphia: Lippincot Williams and Wilkins.

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  • Swerdlow, S. H., Campo, E., Harris, N. L., Jaffe, E. S., Pileri, S. A., Stein, H., & Thiele, J. (2017). WHO classification of tumours of haematopoietic and lymphoid tissues (4th ed.). Lyon: International Agency for Research in Cancer.

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Author information

Authors and Affiliations

  1. Department of Pathology, Hôpital Universitaire Necker-Enfants Malades, AP-HP, Université Paris Descartes, Université de Paris, Paris, France

    Julie Bruneau, Chantal Brouzes, Vahid Asnafi & Thierry Jo Molina

  2. Laboratory of Onco-Hematology, Hôpital Universitaire Necker-Enfants Malades, AP-HP, Université Paris Descartes, Université de Paris, Paris, France

    Julie Bruneau, Chantal Brouzes, Vahid Asnafi & Thierry Jo Molina

Authors
  1. Julie Bruneau
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  2. Chantal Brouzes
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  3. Vahid Asnafi
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  4. Thierry Jo Molina
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Corresponding author

Correspondence to Thierry Jo Molina .

Editor information

Editors and Affiliations

  1. NIJMEGEN, The Netherlands

    J.H.J.M. van Krieken

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Cite this entry

Bruneau, J., Brouzes, C., Asnafi, V., Molina, T.J. (2019). Bone Marrow. In: van Krieken, J. (eds) Encyclopedia of Pathology. Encyclopedia of Pathology. Springer, Cham. https://doi.org/10.1007/978-3-319-28845-1_3875-1

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  • DOI: https://doi.org/10.1007/978-3-319-28845-1_3875-1

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-28845-1

  • Online ISBN: 978-3-319-28845-1

  • eBook Packages: Springer Reference MedicineReference Module Medicine

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