Lymphoplasmacytic lymphoma (LPL) is defined as a B-cell lymphoma consisting of a mixture of lymphocytes, plasmacytic lymphocytes, and monoclonal plasma cells that does not conform to any other entity of small B-cell lymphoma with plasmacytic differentiation (Swerdlow et al. 2017). LPL typically manifests in the bone marrow and spleen and less frequently in lymph nodes and other organs. Waldenström Macroglobulinemia (WM) is defined as a malignant lymphoma with the morphology of LPL involving the bone marrow and that is associated with monoclonal IgM paraproteinemia; vice versa, an IgM monoclonal paraprotein can be detected in the majority of LPL patients. Identification of the LPL hallmark mutation MYD88 L265P has greatly facilitated and added in the specification of the diagnosis.
Incidence and Epidemiology
LPL is a rare disease representing approximately 2% of non-Hodgkin lymphomas. Patients usually present at a median age of roughly 70 years, and the male gender...
References and Further Reading
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- Sohani, A. R., Rodig, S. J., & Harris, N. L. (2017). Lymphoplasmacytic lymphoma and waldenström macroglobulinemia. In E. S. Jaffe, D. A. Arber, E. Campo, N. L. Harris, & L. Quintanilla-Fend (Eds.), Hematopathology (2nd, p. 285). Saunders/Elsevier, Philadelphia.Google Scholar
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