Introduction
In the fourth edition of the WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues (Swerdlow et al. 2017), neoplasms derived from histiocytes and dendritic cells (HDCT) were gathered together based on the functional properties of their normal counterpart (i.e., phagocytosis, processing and presentation of antigens to lymphoid elements, etc.) more than histogenesis. In fact, although most of these elements derive from a common myeloid precursor, some recognize a mesenchymal origin (e.g., follicular dendritic cells). Importantly, HDCT tend to reproduce the morphologic, phenotypic, and ultrastructural characteristics of terminally differentiated elements, i.e., mature histiocytes and different categories of dendritic cells. In line with this, in the fourth edition of the WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues, blastic plasmacytoid dendritic cell tumor (Swerdlow et al. 2017; Marafioti et al. 2008) was excluded from the HDCT chapter...
References and Further Reading
Allen, C.E, & Parsons, D.W. (2015). Biological and clinical significance of somatic mutations in Langerhans cell histiocytosis and related histiocytic neoplastic disorders. Hematology, American Society of Hematology Educational Programme, 2015, 559–64.
Badalian-Very, G., Vergilio, J. A., Degar, B. A., Rodriguez-Galindo, C., & Rollins, B. J. (2012). Recent advances in the understanding of Langerhans cell histiocytosis. British Journal of Haematology, 156, 163–172.
Beasley, M. B. (2010). Smoking-related small airway disease – a review and update. Advances in Anatomic Pathology, 17, 270–276.
Benharroch, D., Guterman, G., Levy, I., & Shaco-Levy, R. (2010). High content of Langerhans cells in malignant lymphoma – incidence and significance. Virchows Archives, 457, 63–67.
Boerkamp, K. M., van der Kooij, M., van Steenbeek, F. G., et al. (2013). Gene expression profiling of histiocytic sarcomas in a canine model: The predisposed flatcoated retriever dog. PLoS One, 8, e71094.
Campochiaro C, Tomelleri A, Cavalli G, et al. (2015). Erdheim-Chester disease. European Journal of Internal Medicine, 26, 223–229.
Chan, J. K., Lamant, L., Algar, E., et al. (2008). ALK+ histiocytosis: A novel type of systemic histiocytic proliferative disorder of early infancy. Blood, 112, 2965–2968.
Chen, W., Jaffe, R., Zhang, L., et al. (2013). Langerhans cell sarcoma arising from chronic lymphocytic lymphoma/small lymphocytic leukemia: Lineage analysis and BRAF V600E mutation study. North American Journal of Medical Sciences, 5, 386–391.
Cohen-Aubart, F., Emile, J. F., Maksud, P., et al. (2014). Marked efficacy of vemurafenib in suprasellar Erdheim-Chester disease. Neurology, 83, 1294–1296.
Dalia, S., Jaglal, M., Chervenick, P., Cualing, H., & Sokol, L. (2014a). Clinicopathologic characteristics and outcomes of histiocytic and dendritic cell neoplasms: The Moffitt cancer center experience over the last twenty-five years. Cancers, 6, 2275–2295.
Dalia, S., Shao, H., Sagatys, E., Cualing, H., & Sokol, L. (2014b). Dendritic cell and histiocytic neoplasms: Biology, diagnosis, and treatment. Cancer Control, 21, 290–300.
Donadieu, J., Chalard, F., & Jeziorski, E. (2012). Medical management of langerhans cell histiocytosis from diagnosis to treatment. Expert Opinion on Pharmacotherapy, 13, 1309–1322.
Falini, B., Pileri, S., De Solas, I., et al. (1990). Peripheral T-cell lymphoma associated with hemophagocytic syndrome. Blood, 75, 434–444.
Facchetti, F., Pileri, S.A., Lorenzi, L., et al. (2017). Histiocytic and dendritic cell neoplasms: what have we learnt by studying 67 cases. Virchows Archives, 371, 467–489
Feldman, A. L., Arber, D. A., Pittaluga, S., et al. (2008). Clonally related follicular lymphomas and histiocytic/dendritic cell sarcomas: Evidence for trans-differentiation of the follicular lymphoma clone. Blood, 111, 5433–5439.
Go, H., Jeon, Y. K., Huh, J., Choi, S. J., Choi, Y. D., Cha, H. J., Kim, H. J., Park, G., Min, S., & Kim, J. E. (2014). Frequent detection of BRAF(V600E) mutations in histiocytic and dendritic cell neoplasms. Histopathology, 65, 261–272.
Griffin, G.K., Sholl, L.M., Lindeman, N.I., et al. (2016). Targeted genomic sequencing of follicular dendritic cell sarcoma reveals recurrent alterations in NF-κB regulatory genes. Modern Pathology, 29, 67–74.
Haroche, J., Charlotte, F., Arnaud, L., et al. (2012). High prevalence of BRAF V600E mutations in Erdheim-Chester disease but not in other non-Langerhans cell histiocytoses. Blood, 120, 2700–2703.
Hartmann, S., Döring, C., Agostinelli, C., et al. (2016). miRNA expression profiling divides follicular dendritic cell sarcomas into two groups, related to fibroblasts and myopericytomas or Castleman’s disease. European Journal of Cancer, 64, 159–66.
Idbaih, A., Mokhtari, K., Emile, J. F., et al. (2014). Dramatic response of a BRAF V600E-mutated primary CNS histiocytic sarcoma to vemurafenib. Neurology, 83, 1478–1480.
Juvet, S. C., Hwang, D., & Downey, G. P. (2010). Rare lung diseases III: Pulmonary Langerhans’ cell histiocytosis. Canadian Respiratory Journal, 17, e55–e62.
Kairouz, S., Hashash, J., Kabbara, W., McHayleh, W., & Tabbara, I. A. (2007). Dendritic cell neoplasms: An overview. American Journal of Hematology, 82, 924–928.
Kansal, R., Quintanilla-Martinez, L., Datta, V., Lopategui, J., Garshfield, G., & Nathwani, B. N. (2013). Identification of the V600D mutation in exon 15 of the BRAF oncogene in congenital, benign Langerhans cell histiocytosis. Genes, Chromosomes and Cancer, 52, 99–106.
Laginestra, M.A., Tripodo, C., Agostinelli, C., et al. (2017). Distinctive histogenesis and immunological microenvironment based on transcriptional profiles of follicular dendritic cell sarcomas. Molecular Cancer Research, 5, 541–52.
Lorenzi, L., Lonardi, S., Petrilli, G., et al. (2012). Folliculocentric B-cell-rich follicular dendritic cells sarcoma: A hitherto unreported morphological variant mimicking lymphoproliferative disorders. Human Pathology, 43, 209–215.
Marafioti, T., Paterson, J. C., Ballabio, E., et al. (2008). Novel markers of normal and neoplastic human plasmacytoid dendritic cells. Blood, 111, 3778–3792.
Méhes, G., Irsai, G., Bedekovics, J., et al. (2014). Activating BRAF V600E mutation in aggressive pediatric Langerhans cell histiocytosis: Demonstration by allele-specific PCR/direct sequencing and immunohistochemistry. American Journal of Surgical Pathology, 38, 1644–1648.
O’Malley, D. P., Zuckerberg, L., Smith, L. B., et al. (2014). The genetics of interdigitating dendritic cell sarcoma share some changes with Langerhans cell histiocytosis in select cases. Annals of Diagnostic Pathology, 18, 18–20.
Ohtake, H., & Yamakawa, M. (2013). Interdigitating dendritic cell sarcoma and follicular dendritic cell sarcoma: Histopathological findings for differential diagnosis. Journal of Clinical and Experimental Hematopathology, 53, 179–184.
Perkins, S. M., & Shinohara, E. T. (2013). Interdigitating and follicular dendritic cell sarcomas: A SEER analysis. American Journal of Clinical Oncology, 36, 395–398.
Pileri, S., & Falini, B. (1990). Peripheral T-cell lymphoma associated with hemophagocytic syndrome and hemophagocytic lymphohistiocytosis of children: Do they share something? Blood, 76, 2163–2164.
Pileri, S. A., Grogan, T. M., Harris, N. L., et al. (2002). Tumours of histiocytes and accessory dendritic cells: An immunohistochemical approach to classification from the International Lymphoma Study Group based on 61 cases. Histopathology, 41, 1–29.
Ratei, R., Hummel, M., Anagnostopoulos, I., et al. (2010). Common clonal origin of an acute B-lymphoblastic leukemia and a Langerhans’ cell sarcoma: Evidence for hematopoietic plasticity. Haematologica, 95, 1461–1466.
Rezk, S. A., Nathwani, B. N., Zhao, X., & Weiss, L. M. (2013). Follicular dendritic cells: Origin, function, and different disease-associated patterns. Human Pathology, 44, 937–950.
Roden, A. C., Hu, X., Kip, S., et al. (2014). BRAF V600E expression in Langerhans cell histiocytosis: Clinical and immunohistochemical study on 25 pulmonary and 54 extrapulmonary cases. American Journal of Surgical Pathology, 38, 548–551.
Sahm, F., Capper, D., Preusser, M., et al. (2012). BRAFV600E mutant protein is expressed in cells of variable maturation in Langerhans cell histiocytosis. Blood, 120, e28–e34.
Saygin, C., Uzunaslan, D., Ozguroglu, M., Senocak, M., & Tuzuner, N. (2013). Dendritic cell sarcoma: A pooled analysis including 462 cases with presentation of our case series. Critical Reviews in Oncology/Hematology, 88, 253–271.
Schuerfeld, K., Lazzi, S., de Santi, M. M., Gozzetti, A., Leoncini, L., & Pileri, S. A. (2003). Cytokeratin-positive interstitial cell neoplasm: A case report and classification issues. Histopathology, 43, 491–494.
Shao, H., Xi, L., Raffeld, M., Feldman, A. L., et al. (2011). Clonally related histiocytic/dendritic cell sarcoma and chronic lymphocytic leukemia/small lymphocytic lymphoma: A study of seven cases. Modern Pathology, 24, 1421–1432.
Suárez-Vilela, D., Izquierdo, F. M., Méndez-Alvarez, J. R., & Escobar-Stein, J. (2012). Neoplasms of dendritic cells: Related cell origins and diagnostic markers. Fibroblastic reticulum cells and fibroblastic reticulum cell tumors show several immunophenotypic profiles. Human Pathology, 43, 1530–1531.
Swerdlow, S. H., Campo, E., Harris, N. L., Jaffe, E. S., Pileri, S. A., Stein, H., & Thiele, J. (Eds.). (2017). WHO classification of tumours of haematopoietic and lymphoid tissue. Revised 4th edition. Lyon: IARC Press. Chapter 17.
Takahashi, E., & Nakamura, S. (2013). Histiocytic sarcoma: An updated literature review based on the 2008 WHO classification. Journal of Clinical and Experimental Hematopathology, 53, 1–8.
Vermi, W., Lonardi, S., Bosisio, D., et al. (2008). Identification of CXCL13 as a new marker for follicular dendritic cell sarcoma. Journal of Pathology, 216, 356–364.
Weiss, G. J., Alarcon, A., Halepota, M., Penny, R. J., & Von Hoff, D. D. (2010). Molecular characterization of interdigitating dendritic cell sarcoma. Rare Tumors, 2, e50.
Wilejto, M., & Abla, O. (2012). Langerhans cell histiocytosis and Erdheim-Chester disease. Current Opinion in Rheumatology, 24, 90–96.
Yousem, S. A., Dacic, S., Nikiforov, Y. E., & Nikiforova, M. (2013). Pulmonary Langerhans cell histiocytosis: Profiling of multifocal tumors using next-generation sequencing identifies concordant occurrence of BRAF V600E mutations. Chest, 143, 1679–1684.
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Pileri, S.A., Tabanelli, V., Agostinelli, C. (2018). Histiocytic Neoplasma. In: van Krieken, J. (eds) Encyclopedia of Pathology. Encyclopedia of Pathology. Springer, Cham. https://doi.org/10.1007/978-3-319-28845-1_3863-1
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