Encyclopedia of Pathology

Living Edition
| Editors: J.H.J.M. van Krieken

HIV-Associated Lymphoid Disorders

  • Antonino CarboneEmail author
  • Annunziata Gloghini
Living reference work entry
DOI: https://doi.org/10.1007/978-3-319-28845-1_3840-1

Synonyms

Definition

Lymphomas represent the most frequent malignancy among people infected with human immunodeficiency virus (HIV). Characteristically these lymphomas have high-grade malignancy and are in advanced stage, with extranodal involvement (Swerdlow et al. 2008). The most common lymphomas arising in the presence of HIV-associated immunosuppression include Burkitt lymphoma (BL) and diffuse large B-cell lymphoma (DLBCL). Classical Hodgkin lymphoma (cHL) is also increased in the setting of HIV, but it less frequent than BL and DLBCL. Additional lymphomas occurring in HIV-infected patients include primary effusion lymphoma (PEL) and its solid variants, lymphoma associated with Kaposi sarcoma herpesvirus (KSHV)-related multicentric Castleman disease (MCD), and plasmablastic lymphoma (PBL) of the oral cavity type (Table 1) (Carbone et al. 2016; Dolcetti et al. 2016; Said et al. 2017; Swerdlow et...
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References

  1. Carbone, A., Vaccher, E., Gloghini, A., Pantanowitz, L., Abayomi, A., de Paoli, P., & Franceschi, S. (2014). Diagnosis and management of lymphomas and other cancers in HIV-infected patients. Nature Reviews. Clinical Oncology, 11, 223–238.CrossRefGoogle Scholar
  2. Carbone, A. & Gloghini, A. (2018) Epstein Barr Virus-Associated Hodgkin Lymphoma. Cancers,10, 163.CrossRefGoogle Scholar
  3. Carbone, A., Gloghini, A., Caruso, A., De Paoli, P. & Dolcetti, R. (2016). The impact of EBV and HIV infection on the microenvironmental niche underlying Hodgkin lymphoma pathogenesis. International Journal of Cancer, 140, 1233–1245.CrossRefGoogle Scholar
  4. Dolcetti, R., Gloghini, A., Caruso, A. & Carbone A. (2016)A lymphomagenic role for HIV beyond immune suppression? Blood, 127, 1403–1409. CrossRefGoogle Scholar
  5. Dunleavy, K., & Wilson, W. H. (2012). How I treat HIV-associated lymphoma. Blood, 119, 3245–3255.CrossRefGoogle Scholar
  6. Gloghini, A., Dolcetti, R., & Carbone, A. (2013). Lymphomas occurring specifically in HIV-infected patients: from pathogenesis to pathology. Seminars Cancer Biology, 23, 457–467.CrossRefGoogle Scholar
  7. IARC. (2012). IARC monograph on the evaluation of carcinogenic risk to humans: Vol. 100. A review of human carcinogens. Part B: Biological agents. Lyon: IARC.Google Scholar
  8. Shiels, M. S., Engels, E. A., Linet, M. S., Clarke, C. A., Li, J., Hall, H. I., Hartge, P., & Morton, L. M. (2013). The epidemic of non-Hodgkin lymphoma in the United States: Disentangling the effect of HIV, 1992–2009. Cancer Epidemiology Biomarkers Prevention, 22, 1069–1078.CrossRefGoogle Scholar
  9. Said, J., Cesarman, E., Rosenwald, A. & Harris, N.L. (2017). Lymphoma associated with HIV infection. In Swerdlow, S.H., Campo, E., Harris, N.L., Jaffe, E.S., Pileri, S.A., Stein, H., Thiele, J., Arber, T.A., Hasserjian, R.P., Le Beau, M.M., Orazi, A. & Siebert, R. eds. WHO classification of tumours of haematopoietic and lymphoid tissues (pp 449–452) Revised 4th ed. Lyon: IARC.Google Scholar
  10. Simard, E. P., Pfeiffer, R. M., & Engels, E. A. (2011). Cumulative incidence of cancer among individuals with acquired immunodeficiency syndrome in the United States. Cancer, 117, 1089–1096.CrossRefGoogle Scholar
  11. Swerdlow, S. H., Campo, E., Harris, N. L., Jaffe, E. S., Pileri, S. A., Stein, H., Thiele, J., & Vardiman, J. W. (Eds.). (2008). WHO classification of tumours of haematopoietic and lymphoid tissues (4th ed.). Lyon: IARC.Google Scholar
  12. Yarchoan, R. & Uldrick, T.S. (2018). HIV-Associated Cancers and Related Diseases. New England Journal of Medicine, 378, 1029–1041.CrossRefGoogle Scholar

Copyright information

© Springer Nature Switzerland AG 2018

Authors and Affiliations

  1. 1.Department of PathologyCentro di Riferimento Oncologico Aviano, Istituto Nazionale Tumori, IRCCSAvianoItaly
  2. 2.Department of Diagnostic Pathology and Laboratory MedicineFondazione IRCCS, Istituto Nazionale TumoriMilanItaly