Encyclopedia of Pathology

Living Edition
| Editors: J.H.J.M. van Krieken

Addison’s Disease: Primary

  • Jacqueline E. van der WalEmail author
Living reference work entry
DOI: https://doi.org/10.1007/978-3-319-28845-1_2790-1



Hypoadrenocorticism, insufficient production of corticosteroid hormone, caused by a destruction of the adrenal cortex, caused by autoimmune destruction, infections, or metastatic tumors. Fatigue, irritability, depression, weakness, and hypotension may be noted with a generalized hyperpigmentation of the skin and diffuse or patchy, brown, macular pigmentation of the oral mucosa.


Copyright information

© Springer International Publishing AG 2018

Authors and Affiliations

  1. 1.Department of PathologyThe Netherlands Cancer Institute/Antoni van Leeuwenhoek HospitalAmsterdamThe Netherlands