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Ruta graveolens: Phytochemistry, Pharmacology, and Biotechnology

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Transgenesis and Secondary Metabolism

Part of the book series: Reference Series in Phytochemistry ((RSP))

Abstract

Ruta graveolens L., popularly known as rue, is a multipurpose herb belonging to family Rutaceae. It is a rich source of secondary metabolites mainly: coumarins, alkaloids, volatile oils, flavonoids, and phenolic acids. It has been used abundantly worldwide due to its diverse medicinal properties. Extract and essential oil obtained from this plant species have been shown to possess various pharmacological activities including contraceptive, anti-inflammatory, antimicrobial, antipyretic, antioxidant, analgesic, antihyperglycemic, free radical scavenging, hypotensive, antiviral, and antiplasmodial effects. In vitro assays performed with human cell lines have indicated the anticancer potential of furanoacridones and acridone alkaloids isolated from R. graveolens. In vitro approaches have been carried out for rapid clonal multiplication of R. graveolens. Application of hairy root culture has effectively observed to be beneficial for enhanced production of bioactive compounds from this plant species. A review of literature suggests that it is an interesting plant species to pharmaceutical industry due to its potential to produce several pharmacological effects.

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Acknowledgments

Authors would like to acknowledge the Foundation for the Support of Research, Scientific, and Technological Development of the state of Maranhão – FAPEMA for financial support.

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Authors and Affiliations

  1. Graduate Program in Health Sciences, Biological and Health Sciences Center, Federal University of Maranhão, CEP 65085-580, São Luís, MA, Brazil

    Sonia Malik

  2. Department of Pharmacy, Biological and Health Sciences Center, Federal University of Maranhão, 65085-580, São Luís, MA, Brazil

    Denise Fernandes Coutinho Moraes, Flavia Maria Mendonça do Amaral & Maria Nilce Sousa Ribeiro

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  1. Sonia Malik
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  2. Denise Fernandes Coutinho Moraes
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  3. Flavia Maria Mendonça do Amaral
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  4. Maria Nilce Sousa Ribeiro
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Correspondence to Sonia Malik .

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  1. Department of Botany, Centre of Advanced Study, University of Calcutta, Kolkata, India

    Sumita Jha

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Malik, S., Moraes, D.F.C., do Amaral, F.M.M., Ribeiro, M.N.S. (2017). Ruta graveolens: Phytochemistry, Pharmacology, and Biotechnology. In: Jha, S. (eds) Transgenesis and Secondary Metabolism. Reference Series in Phytochemistry. Springer, Cham. https://doi.org/10.1007/978-3-319-28669-3_4

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