Experimental Models of Brain Disease: MRI Studies

  • Ian F. Harrison
  • Jack A. Wells
  • Mark F. Lythgoe
Reference work entry

Abstract

Studies involving dedicated high field MRI systems have mushroomed in recent years. In parallel, modelling of neurological disorders using animals have improved substantially, allowing in depth study of both disease aetiology and the effects of therapeutic agents on such models. In particular, the use of transgenic mouse models has called for high-throughput methods to allow in depth phenotyping of mouse lines, and track disease processes with time. This chapter is dedicated to the use of MRI in small animal models of brain disease, and will describe some of the practical issues surrounding the use of MRI, and review the role of MRI in investigating the pathophysiology of the most common neurological disorders.

Keywords

Alzheimer’s disease Parkinson’s disease Huntington’s disease Stroke traumatic brain injury animal model Multiple Sclerosis preclinical MRI 

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Copyright information

© Springer International Publishing AG, part of Springer Nature 2018

Authors and Affiliations

  • Ian F. Harrison
    • 1
  • Jack A. Wells
    • 1
  • Mark F. Lythgoe
    • 1
  1. 1.UCL Centre for Advanced Biomedical Imaging, Division of MedicineUniversity College LondonLondonUK

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