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Structure and Dynamics of Membrane-Bound Proteins

  • Katsuyuki Nishimura
  • Michikazu Tanio
  • Satoru Tuzi
Reference work entry

Abstract

Several types of membrane proteins, including temporally bound peripheral membrane proteins, lipid-anchored proteins, and protein moieties protruding from the membrane surface, are biologically very important because of the presence of their functional moieties undergoing cell signaling, cytoskeletal rearrangement, and other processes at the membrane surfaces, although these structures have not yet been fully clarified because of their structural heterogeneity. It is emphasized that combined utilization of both solid-state and solution NMR experiments is essential to reveal their substantially varied dynamic structures. In this connection, structural features of amyloid proteins, α-synuclein (αS) and amyloid β (Aβ) protein, bound to membranes were also discussed in relation to their pathogenesis of respective amyloid diseases.

Keywords

Membrane-bound protein Peripheral membrane protein Lipid-anchored protein Membrane-bound amyloid protein Solid-state NMR Solution NMR 

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Copyright information

© Springer International Publishing AG, part of Springer Nature 2018

Authors and Affiliations

  • Katsuyuki Nishimura
    • 1
  • Michikazu Tanio
    • 2
  • Satoru Tuzi
    • 3
  1. 1.Institute for Molecular Science, National Institutes of Natural Sciences, and Graduate University for Advanced StudiesOkazakiJapan
  2. 2.National Institute of Infectious DiseasesTokyoJapan
  3. 3.Graduate School of Life ScienceUniversity of HyogoHyogoJapan

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