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Solid-State NMR on Complex Biomolecules: Methods and Applications

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Modern Magnetic Resonance

Abstract

Solid-state NMR (ssNMR) can provide structural information at the most detailed level and, at the same time, is applicable in highly heterogeneous and complex molecular environments, largely irrespective of solubility or crystallinity. In the following chapter, we discuss concepts to deal with the spectroscopic challenges of applying ssNMR to complex biomolecular systems and how to place structural information obtained from ssNMR in a (supra)molecular context. Applications range from protein biopolymers and hydrogels to drug delivery systems, biosilica, and other biomaterials.

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Acknowledgments

We gratefully acknowledge our collaborators and colleagues for their invaluable contributions to cited publications from our own research group.

These studies were supported through grants from the NWO, the EU, and the NIH, as well as the DFG, the Max Planck Society, and the Volkswagen Foundation.

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Authors and Affiliations

  1. NMR Spectroscopy, Bijvoet Center for Biomolecular Research, Utrecht University, Padualaan 8, 3584, Utrecht, CH, The Netherlands

    Deni Mance, Markus Weingarth & Marc Baldus

Authors
  1. Deni Mance
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  2. Markus Weingarth
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  3. Marc Baldus
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Corresponding author

Correspondence to Marc Baldus .

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Editors and Affiliations

  1. Royal Society of Chemistry, London, United Kingdom

    Graham A. Webb

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Mance, D., Weingarth, M., Baldus, M. (2018). Solid-State NMR on Complex Biomolecules: Methods and Applications. In: Webb, G. (eds) Modern Magnetic Resonance. Springer, Cham. https://doi.org/10.1007/978-3-319-28388-3_33

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