Nonuniform Sampling in Biomolecular NMR

  • Tomas Marko Miljenović
  • Xinying Jia
  • Mehdi Mobli
Reference work entry


Nonuniform sampling (NUS) is no longer an ethereal promise for future NMR spectroscopists. Freedom from comprehensively sampling the Nyquist grid has facilitated an increasing variety of applications in biomolecular NMR studies. We introduce the concepts of multidimensional experiments, sampling, and signal processing before looking at the basics of nonuniform sampling and its benefits. This chapter also includes some practical guidelines for applying NUS to protein NMR studies, and looks at more recent uses of NUS in a wide range of applications in biomolecular NMR.


Nonuniform sampling Non–uniform sampling Multidimensional NMR spectroscopy NMR Proteins Peptides 



The authors would like to acknowledge financial support from the Australian Research Council (ARC Future Fellowship and ARC Discovery Project), the National Health and Medical Research Council (NHMRC Project), and The University of Queensland (Strategic Research Fellowship).


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Copyright information

© Springer International Publishing AG, part of Springer Nature 2018

Authors and Affiliations

  • Tomas Marko Miljenović
    • 1
  • Xinying Jia
    • 1
  • Mehdi Mobli
    • 1
  1. 1.Centre for Advanced ImagingThe University of QueenslandBrisbaneAustralia

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