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Reporter Genes for Magnetic Resonance

Reference work entry

Abstract

The ability to image gene expression in whole live animals promises fresh insights on the biological dynamics of development, disease, and experimental therapies. Established methods for optical or nuclear imaging have several advantages, but lack the high 3D spatial resolution necessary to identify complex internal tissue structure which is offered by MRI. This chapter will introduce the concept of gene reporters (genetically-encoded proteins that produce a signal), their potential applications, and the developments made in this field using Magnetic Resonance-based techniques.

Keywords

Reporter Genes MRI Molecular Imaging NMR MRI Reporter Genes 

Notes

Acknowledgments

PS Patrick is funded by the UK Regenerative Medicine Platform (MRC: MR/K026739/1). TL Kalber is funded by an EPSRC Early Career Fellowship (EP/L006472/1)

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Copyright information

© Springer International Publishing AG, part of Springer Nature 2018

Authors and Affiliations

  1. 1.UCL Centre of Advanced Biomedical Imaging, Division of MedicineUniversity College LondonLondonUK

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