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Reporter Genes for Magnetic Resonance

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Modern Magnetic Resonance

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Abstract

The ability to image gene expression in whole live animals promises fresh insights on the biological dynamics of development, disease, and experimental therapies. Established methods for optical or nuclear imaging have several advantages, but lack the high 3D spatial resolution necessary to identify complex internal tissue structure which is offered by MRI. This chapter will introduce the concept of gene reporters (genetically-encoded proteins that produce a signal), their potential applications, and the developments made in this field using Magnetic Resonance-based techniques.

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Acknowledgments

PS Patrick is funded by the UK Regenerative Medicine Platform (MRC: MR/K026739/1). TL Kalber is funded by an EPSRC Early Career Fellowship (EP/L006472/1)

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Authors and Affiliations

  1. UCL Centre of Advanced Biomedical Imaging, Division of Medicine, University College London, Paul O’Gorman Building, 72 Huntley Street, London, WC1E 6DD, UK

    P. Stephen Patrick & Tammy L. Kalber

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  1. P. Stephen Patrick
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  2. Tammy L. Kalber
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Correspondence to P. Stephen Patrick .

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Editors and Affiliations

  1. Royal Society of Chemistry, London, United Kingdom

    Graham A. Webb

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Patrick, P.S., Kalber, T.L. (2018). Reporter Genes for Magnetic Resonance. In: Webb, G. (eds) Modern Magnetic Resonance. Springer, Cham. https://doi.org/10.1007/978-3-319-28388-3_102

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