Synonyms
Adamantinoma of the jaws
Definition
The ameloblastoma is a benign neoplasm of odontogenic epithelium. It represents one of the most frequently encountered odontogenic neoplasms and is well known for its characteristic histopathologic features and often locally aggressive behavior.
The ameloblastoma is believed to originate from the remnants of dental lamina, the developing enamel organ, the epithelial lining of odontogenic cysts, or the basilar epithelial cells of the gingival surface epithelium. The tumor exhibits a microscopic resemblance to the enamel organ of a developing tooth. Specifically, the tumor epithelial cells may mimic the inner enamel epithelium and stellate reticulum of the enamel organ.
Ameloblastoma includes three major clinicopathologic subtypes: conventional solid and multicystic, unicystic, and peripheral. The remainder of this discussion will focus mainly upon the conventional solid and multicystic type, which represents approximately 90 % of...
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References and Further Reading
Borkosky, S. S., Gunduz, M., Beder, L., Tsujigiwa, H., Tamamura, R., Gunduz, E., et al. (2010). Allelic loss of the ING gene family loci is a frequent event in ameloblastoma. Oncology Research, 18(10), 509–518.
Kawabata, T., Takahashi, K., Sugai, M., Murashima-Suginami, A., Ando, S., Shimizu, A., et al. (2005). Polymorphisms in PTCH1 affect the risk of ameloblastoma. Journal of Dental Research, 84(9), 812–816.
Reichart, P. A., Philipsen, H. P., & Sonner, S. (1995). Ameloblastoma: Biological profile of 3677 cases. European Journal of Cancer. Part B, Oral Oncology, 31B(2), 86–99.
Scheper, M. A., Chaisuparat, R., Nikitakis, N. G., & Sauk, J. J. (2008). Expression and alterations of the PTEN/AKT/mTOR pathway in ameloblastomas. Oral Diseases, 14(6), 561–568.
Shear, M., & Singh, S. (1978). Age-standardized incidence rates of ameloblastoma and dentigerous cyst on the Witwatersrand, South Africa. Community Dentistry and Oral Epidemiology, 6(4), 195–199.
Siriwardena, B. S., Kudo, Y., Ogawa, I., Tilakaratne, W. M., & Takata, T. (2009). Aberrant beta-catenin expression and adenomatous polyposis coli gene mutation in ameloblastoma and odontogenic carcinoma. Oral Oncology, 45(2), 103–108.
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2016 Springer-Verlag Berlin Heidelberg
About this entry
Cite this entry
Chi, A. (2016). Ameloblastoma. In: Slootweg, P.J. (eds) Dental and Oral Pathology. Encyclopedia of Pathology. Springer, Cham. https://doi.org/10.1007/978-3-319-28085-1_653
Download citation
DOI: https://doi.org/10.1007/978-3-319-28085-1_653
Published:
Publisher Name: Springer, Cham
Print ISBN: 978-3-319-28084-4
Online ISBN: 978-3-319-28085-1
eBook Packages: MedicineReference Module Medicine