Definition
Most authorities regard the ameloblastic fibroma as a benign neoplasm of odontogenic epithelium and ectomesenchyme (or “mixed odontogenic tumor”). However, some investigators have hypothesized that at least some cases of ameloblastic fibroma may be hamartomatous and represent the earliest stage in the development of an odontoma. Nevertheless, the appreciable recurrence potential of ameloblastic fibroma appears to favor a neoplastic nature. Furthermore, the average age at diagnosis is somewhat older for the ameloblastic fibroma compared to that for the odontoma, which would not support the concept that the lesion represents the earliest stage in the development of an odontoma.
Clinical Features
Incidence
The incidence of ameloblastic fibroma is unknown. However, it appears to be rare and comprises approximately 1.5–4.5 % of odontogenic tumors (Philipsen et al. 1997).
Age
The ameloblastic fibroma exhibits a marked predilection for young individuals, with an average age at...
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References and Further Reading
Becker, J., Reichart, P. A., Schuppan, D., & Philipsen, H. P. (1992). Ectomesenchyme of ameloblastic fibroma reveals a characteristic distribution of extracellular matrix proteins. Journal of Oral Pathology & Medicine, 21(4), 156–159.
Carnelio, S., & Vij, H. (2010). Expression of tenascin and nucleolar organizer region in ameloblastoma and ameloblastic fibroma. Journal of Oral Pathology & Medicine, 39(3), 223–229.
Chen, Y., Wang, J. M., & Li, T. J. (2007). Ameloblastic fibroma: A review of published studies with special reference to its nature and biological behavior. Oral Oncology, 43(10), 960–969.
Heikinheimo, K., Voutilainen, R., Happonen, R. P., & Miettinen, P. J. (1993). EGF receptor and its ligands, EGF and TGF-alpha, in developing and neoplastic human odontogenic tissues. International Journal of Developmental Biology, 37(3), 387–396.
Philipsen, H. P., Reichart, P. A., & Praetorius, F. (1997). Mixed odontogenic tumours and odontomas. Considerations on interrelationship. Review of the literature and presentation of 134 new cases of odontomas. Oral Oncology, 33(2), 86–99.
Sano, K., Yoshida, S., Ninomiya, H., Ikeda, H., Ueno, K., Sekine, J., et al. (1998). Assessment of growth potential by MIB-1 immunohistochemistry in ameloblastic fibroma and related lesions of the jaws compared with ameloblastic fibrosarcoma. Journal of Oral Pathology & Medicine, 27(2), 59–63.
Takeda, Y. (1999). Ameloblastic fibroma and related lesions: Current pathologic concept. Oral Oncology, 35(6), 535–540.
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Chi, A. (2016). Ameloblastic Fibroma. In: Slootweg, P.J. (eds) Dental and Oral Pathology. Encyclopedia of Pathology. Springer, Cham. https://doi.org/10.1007/978-3-319-28085-1_651
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DOI: https://doi.org/10.1007/978-3-319-28085-1_651
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