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The Endocrine Heart

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Book cover Principles of Endocrinology and Hormone Action

Part of the book series: Endocrinology ((ENDOCR))

Abstract

Mammalian hearts express and secrete natriuretic peptides. Atrial natriuretic peptide (ANP) was the first to be identified in atria of rodents, and today the cardiac peptides consist of also the structurally related B-type natriuretic peptide – or BNP. Both peptide hormones have important hemodynamic properties including regulation of blood pressure and intravascular fluid hemostasis. As biomarkers, biosynthetic precursor fragments have gained a robust function in the assessment of human heart failure, where the markers are used primarily as exclusion markers. As drugs, both ANP and BNP, and derivatives of these peptides, seem promising as therapy in heart failure patients and in hypertension. Moreover, the cardiac peptide hormones may also possess organ-protective effects, where kidney function and cardiac remodeling seem in particular relevant.

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Authors and Affiliations

  1. Department of Pathology and Laboratory Medicine, University of Ottawa, Faculty of Medicine, and the University of Ottawa, Heart Institute, 451 Smyth (4155), Ottawa, ON, K1H 8M5, Canada

    Adolfo J. de Bold

  2. Department of Cardiovascular Diseases, Cardiorenal Research Laboratory, The Mayo Clinic, 200 1st St Sw, Rochester, MN, 55905, USA

    John C. Burnett Jr.

  3. Department of Clinical Biochemistry, Rigshospitalet, and University of Aarhus, Rigshospitalet, Blegdamsvej 9, DK-2100, Copenhagen, Denmark

    Jens Peter Goetze

  4. Department of Clinical Medicine, Aarhus University, Aarhus, Denmark

    Jens Peter Goetze

Authors
  1. Adolfo J. de Bold
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  2. John C. Burnett Jr.
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  3. Jens Peter Goetze
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Correspondence to Adolfo J. de Bold .

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  1. Department of Health Sciences, University Magna Graecia of Catanzaro, Catanzaro, Italy

    Antonino Belfiore

  2. Diabetes and Metabolism Clinical Researc, Clinical Research Institute at Rambam (C, Haifa, Israel

    Derek LeRoith

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de Bold, A.J., Burnett, J.C., Goetze, J.P. (2016). The Endocrine Heart. In: Belfiore, A., LeRoith, D. (eds) Principles of Endocrinology and Hormone Action. Endocrinology. Springer, Cham. https://doi.org/10.1007/978-3-319-27318-1_20-1

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