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Diabetes. Epidemiology, Genetics, Pathogenesis, Diagnosis, Prevention, and Treatment pp 1–40Cite as

Islet Cell or Pancreas Transplantation

  • Living reference work entry
  • First Online:

Part of the book series: Endocrinology ((ENDOCR))

Abstract

Islet cell or pancreas transplantation is the only long-term diabetes treatment that consistently results in normal hemoglobin A1c levels without the risk of severe hypoglycemia. Additionally, islet cell or pancreas transplantation may prevent, halt, or even reverse the complications of diabetes. Consequently, it is an important part of the management of a subset of patients with diabetes, namely, those in renal failure and those with life-threatening complications of their diabetes such as hypoglycemic unawareness. Here, we explore the indications, options, and outcomes of islet cell or pancreas transplantation as a treatment for diabetes mellitus. The morbidity of solid-organ pancreas transplantation restricts pancreas transplantation to relatively younger and fitter patients. Islet cell transplantation is less invasive and, therefore, more appealing to patients, endocrinologists, and diabetologists. Pancreas transplants and islet transplants should be considered complementary, not mutually exclusive, procedures that are chosen on the basis of the individual patient’s surgical risk. As the mortality and morbidity of solid pancreas transplantation diminish and the longer-term outcomes of both solid-organ and islet transplantation improve, the appropriate indications for both procedures will expand, particularly with the increasing incidence of diabetes as well as evidence that transplantation is suitable not only for type 1 diabetics but also for selected insulin-dependent patients with type 2 diabetes.

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Authors and Affiliations

  1. Diabetes Research Institute (SR-DRI), IRCCS San Raffaele Scientific Institute, Milan, Italy

    Lorenzo Piemonti, Rita Nano & Paola Maffi

  2. Internal Medicine and Transplant Unit, Vita-Salute San Raffaele University, Milan, Italy

    Lorenzo Piemonti & Antonio Secchi

  3. Unit of Transplant Surgery, IRCCS San Raffaele Scientific Institute, Milan, Italy

    Carlo Socci

  4. Clinical Transplant Unit, IRCCS San Raffaele Scientific Institute, Milan, Italy

    Paola Maffi

  5. Internal Medicine and Transplant Unit, Milan, Italy

    Antonio Secchi

Authors
  1. Lorenzo Piemonti
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  2. Carlo Socci
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  3. Rita Nano
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  4. Paola Maffi
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  5. Antonio Secchi
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Corresponding author

Correspondence to Lorenzo Piemonti .

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Editors and Affiliations

  1. Endocrinology, Diabetes and Metabolism, University of Verona, Verona, Italy

    Enzo Bonora

  2. Diabetes Division, UTHSCSA, San Antonio, Texas, USA

    Ralph DeFronzo

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Piemonti, L., Socci, C., Nano, R., Maffi, P., Secchi, A. (2018). Islet Cell or Pancreas Transplantation. In: Bonora, E., DeFronzo, R. (eds) Diabetes. Epidemiology, Genetics, Pathogenesis, Diagnosis, Prevention, and Treatment. Endocrinology. Springer, Cham. https://doi.org/10.1007/978-3-319-27317-4_23-1

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  • DOI: https://doi.org/10.1007/978-3-319-27317-4_23-1

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  • Print ISBN: 978-3-319-27317-4

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