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Intraductal Neoplasms of the Biliary Tract

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Tumors and Tumor-Like Lesions of the Hepatobiliary Tract

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Abstract

Intraductal papillary neoplasm of the bile duct (IPN-B) is a rare epithelial bile duct tumor characterized by a predominantly papillary growth pattern, a phase of intraluminal noninvasive growth, and a later high risk of transition into invasive cholangiocarcinoma. A recently proposed more general term is intraductal neoplasm of the bile duct (IN-B), because not all of these neoplasms are papillary lesions. IPN-B is now regarded as the biliary counterpart of intraductal mucinous papillary neoplasm of the pancreas. Histologically, the majority of IPN-Bs exhibit a papillary or tubulopapillary morphology, but a rarer variant is characterized by a tubular morphology. A mucinous phenotype, which is regularly found in pancreatic intraductal neoplasms, is not a constant finding in IPN-B. IPN-B lesions undergo dysplastic changes, divided into four groups, i.e., low-grade dysplasia, high-grade dysplasia, carcinoma in situ, and IPN-B associated with invasive carcinoma. In analogy to pancreatic lesions, IPN-B is subclassified into branch duct type, main duct type, and mixed type. Distinct epithelial changes developing in peribiliary glands are considered as precursor lesions of IPN-B.

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    Arthur Zimmermann

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Zimmermann, A. (2017). Intraductal Neoplasms of the Biliary Tract. In: Tumors and Tumor-Like Lesions of the Hepatobiliary Tract. Springer, Cham. https://doi.org/10.1007/978-3-319-26956-6_33

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