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Hepatoid Carcinomas (Adenocarcinomas with Hepatoid Features)

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Tumors and Tumor-Like Lesions of the Hepatobiliary Tract

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Abstract

Hepatoid carcinoma (adenocarcinoma with hepatoid features) is a highly aggressive carcinoma occurring in various organs, morphologically characterized by the presence of HCC-like cells that frequently express alpha-fetoprotein, but with a cytokeratin pattern that differs from that of classical HCC, in that tumor cells are often positive for cytokeratins 7 and 20. Similar to HCC, gastrointestinal hepatoid carcinomas can express the hepatocyte marker Hep Par 1. These neoplasms are associated with rapid progression and a poor outcome. Most hepatoid carcinomas found in the liver are metastases of gastric hepatoid carcinomas, the stomach being a frequent primary site. Primary hepatoid carcinomas also occur in bile ducts, the gallbladder, and the ampullary region, but these are uncommon locations. The histogenesis of this neoplasm has not yet been elucidated.

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Authors and Affiliations

  1. University of Bern, Bern, Switzerland

    Arthur Zimmermann

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  1. Arthur Zimmermann
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Correspondence to Arthur Zimmermann .

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Zimmermann, A. (2017). Hepatoid Carcinomas (Adenocarcinomas with Hepatoid Features). In: Tumors and Tumor-Like Lesions of the Hepatobiliary Tract. Springer, Cham. https://doi.org/10.1007/978-3-319-26956-6_17

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  • DOI: https://doi.org/10.1007/978-3-319-26956-6_17

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-26954-2

  • Online ISBN: 978-3-319-26956-6

  • eBook Packages: MedicineReference Module Medicine

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