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Tumors and Tumor-Like Lesions of the Hepatobiliary Tract pp 293–304Cite as

Hepatocellular Carcinoma with Progenitor Cell Features

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Abstract

Subsets of hepatocellular carcinoma (HCC) can harbor hepatic progenitor cells or stem-like cells (HCCs with progenitor cell features). Stem/progenitor cells were also identified in combined hepatocellular-cholangiocarcinoma. Stem/progenitor cells detectable in HCCs share a marker profile with normal hepatic stem cells, but tumor cells may be deficient in part of the markers. For most progenitor cell features in HCC, the biologic significance is not yet clarified. However, there is strong evidence that expression of cytokeratin 19 as a stemness feature is associated with a high-risk biology of these neoplasms. The incidence of marked cytokeratin 19 expression in HCC cells is only partially known, but may amount to 10 %. Cytokeratin 19 expression in HCC may occur in combination with other stem cell-associated markers and is associated with expression of proteins involved in epithelial-to-mesenchymal transition. Cytokeratin 19 expression in HCCs predicts higher serum alpha-fetoprotein levels, tumor angiogenesis, accelerated tumor progression, early recurrence, and poorer survival.

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  1. University of Bern, Bern, Switzerland

    Arthur Zimmermann

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  1. Arthur Zimmermann
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Zimmermann, A. (2017). Hepatocellular Carcinoma with Progenitor Cell Features. In: Tumors and Tumor-Like Lesions of the Hepatobiliary Tract. Springer, Cham. https://doi.org/10.1007/978-3-319-26956-6_14

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  • DOI: https://doi.org/10.1007/978-3-319-26956-6_14

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