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Inflammatory Hepatic Carcinomas

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Tumors and Tumor-Like Lesions of the Hepatobiliary Tract

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Abstract

Rare variants of hepatocellular carcinoma (HCC) show dense infiltrates of several classes of mononuclear leukocytes, mainly lymphocytes and macrophages or histiocytes (inflammatory HCCs). As a sign of an antitumor immune reaction, most ordinary HCCs exhibit lymphocyte and macrophage infiltrates of low density, but this feature does not qualify for a diagnosis of inflammatory HCC. Uncommon HCCs display a massive lymphoid cell infiltration, mostly T cells (HCC with lymphoid stroma). A very rare variant of HCC shows dense plasmacytic infiltrates, associated with tumor cell apoptosis and tumor regression (medullary-like HCC). There are also uncommon HCCs rich in macrophages or histiocytes with or without epithelioid cell reaction. A last group of inflammatory HCCs are lymphoepithelial liver tumors (lymphoepithelial carcinomas) which also occur in the biliary tract and several extrahepatic locations. Part of the latter neoplasms is associated with Epstein-Barr virus infection.

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  1. University of Bern, Bern, Switzerland

    Arthur Zimmermann

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Zimmermann, A. (2017). Inflammatory Hepatic Carcinomas. In: Tumors and Tumor-Like Lesions of the Hepatobiliary Tract. Springer, Cham. https://doi.org/10.1007/978-3-319-26956-6_12

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