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Fungal Metabolites pp 853–885Cite as

Fungal Protease Inhibitors

  • Reference work entry
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Part of the book series: Reference Series in Phytochemistry ((RSP))

Abstract

Fungi constitute an enormous unexplored pool of protease inhibitors. Only a handful of fungal protease inhibitors have been exhaustively characterized, but they reveal great versatility and many unique features and novel types of inhibitory mechanisms. Small molecule and protein inhibitors of all catalytic classes of proteases have been identified in fungi, those that target serine proteases predominating. As important regulators of proteases, the function and potential applications of protease inhibitors are intimately connected with those of proteases they inhibit. In this chapter, both small molecule and protein protease inhibitors from fungi are described, including their biochemical characteristics, inhibitory mechanisms, and biological functions together with their potential for application in the fields of biotechnology, crop protection, and medicine.

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Abbreviations

ACE:

Angiotensin I-converting enzyme

AFLEI:

Aspergillus flavus elastase inhibitor

AFUEI:

Aspergillus fumigatus elastase inhibitor

BIR:

Baculoviral inhibitor of apoptosis protein repeat

CVPI:

Coriolus versicolor pepsin inhibitor

E-64:

l-N-trans-Epoxysuccinyl-leucylamido(4-guanidino)butane

GLPIA2:

Ganoderma lucidum proteinase A inhibitor 2

IAP:

Inhibitor of apoptosis

LeSPI:

Lentinula edodes serine protease inhibitor

PDB:

Protein Data Bank

POIA:

Pleurotus ostreatus proteinase A inhibitor

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Authors and Affiliations

  1. Department of Biotechnology, Jožef Stefan Institute, Ljubljana, Slovenia

    Jerica Sabotič & Janko Kos

  2. Department of Pharmaceutical Biology, Faculty of Pharmacy, University of Ljubljana, Ljubljana, Slovenia

    Janko Kos

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  1. Jerica Sabotič
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Correspondence to Jerica Sabotič .

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  1. Faculty of Pharmaceutical Sciences, University of Bordeaux, Bordeaux, France

    Jean-Michel Mérillon

  2. Botany Department, M.L.Sukhadia University, Udaipur, Rajasthan, India

    Kishan Gopal Ramawat

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Sabotič, J., Kos, J. (2017). Fungal Protease Inhibitors. In: Mérillon, JM., Ramawat, K. (eds) Fungal Metabolites. Reference Series in Phytochemistry. Springer, Cham. https://doi.org/10.1007/978-3-319-25001-4_10

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