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Critical Care Toxicology pp 1–18Cite as

Carbon Monoxide

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Abstract

This chapter reviews the clinical presentation, mechanisms of toxicity, and clinical management of carbon monoxide (CO) poisoning. Emphasis is placed on the mechanisms for toxic effects of CO because this provides a demonstration of the continuum of CO-mediated effects, highlights common pitfalls in clinical management, and underscores the challenges that exist in clinical investigations.

This chapter is an update of the chapter by Stephen R. Thom that appeared in the first edition of this book.

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References

  1. National Safety Council. How people died in home accidents, 1981. In: Accident facts, 1982 ed. Chicago: National Safety Council; 1982. p. 80–4.

    Google Scholar 

  2. Cobb N, Etzel RA. Unintentional carbon monoxide-related deaths in the United States, 1979 through 1988. JAMA. 1991;266:659–63.

    Article  CAS  PubMed  Google Scholar 

  3. Mathieu D, Mathieu-Nolf M, Wattel F. Intoxication par le monoxyde de carbone: aspects actuels [carbon monoxide poisoning: present aspects]. Bull Acad Natl Med (Paris). 1996;180:965–73.

    CAS  Google Scholar 

  4. Meredith T, Vale A. Carbon monoxide poisoning. BMJ. 1988;296:77–9.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  5. Gajdos P, Conso M, Korach JM, et al. Incidence and causes of carbon monoxide intoxication: results of an epidemiological survey in a French department. Arch Environ Health. 1991;46:373–6.

    Article  CAS  PubMed  Google Scholar 

  6. Gujer H. Accidental CO poisoning caused by incomplete combustion of liquid gases. Soz Pravantivmed. 1982;27:39–42.

    Article  CAS  Google Scholar 

  7. Hung D, Deng J, Yang C, et al. The climate and the occurrence of carbon monoxide poisoning in Taiwan. Hum Exp Toxicol. 1994;13:493–5.

    Article  CAS  PubMed  Google Scholar 

  8. Kim Y. Seasonal variation in carbon monoxide poisoning in urban Korea. J Epidemiol Community Health. 1985;39:79–81.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  9. Milis L, Lagasse R. Carbon monoxide poisoning in the Brussels metropolitan area: home survey technics and proposals for action. Arch Belg. 1989;47:24–8.

    CAS  PubMed  Google Scholar 

  10. Saunders PJ. Surveillance of non-infectious environmental hazards in the West Midlands. Chem Incident. 1996;1:1.

    Google Scholar 

  11. Taudorf K, Michelsen K. The danger of CO poisoning from gas water heaters: a study of 124 systems and their uses. Ugeskr Laeger. 1983;145:3593–8.

    CAS  PubMed  Google Scholar 

  12. Theilade P. Carbon monoxide poisoning: five years’ experience of a defined population. Am J Forensic Med Pathol. 1990;11:219–25.

    Article  CAS  PubMed  Google Scholar 

  13. Thomsen JL, Kardel T. Accidents caused by gas water heaters: fatalities and a non fatal case. Ugeskr Laeger. 1983;145:3598–600.

    CAS  PubMed  Google Scholar 

  14. Wilson RC, Saunders PJ, Smith G. An epidemiological study of acute carbon monoxide poisoning in the West Midlands. Occup Environ Med. 1998;55:723–8.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  15. Cook M, Simon PA, Hoffman RE. Unintentional carbon monoxide poisoning in Colorado, 1986 through 1991. Am J Public Health. 1995;85:988–90.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  16. Hampson NB. Emergency department visits for carbon monoxide poisoning in the Pacific Northwest. J Emerg Med. 1998;16:695–8.

    Article  CAS  PubMed  Google Scholar 

  17. Heimbach DM, Waeckerle JF. Inhalation injuries. Ann Emerg Med. 1988;17:1316–20.

    Article  CAS  PubMed  Google Scholar 

  18. Miller RL, Toal BF, Foscue K, et al. Unintentional carbon monoxide poisonings in residential settings – Connecticut, November 1993–March 1994. MMWR Morb Mortal Wkly Rep. 1995;44:765–7.

    Google Scholar 

  19. Barret L, Danel V, Faure J. Carbon monoxide poisoning, a diagnosis frequently overlooked. Clin Toxicol. 1985;23:309–13.

    CAS  Google Scholar 

  20. Molitor L. A 45-year-old woman with flu symptoms. J Emerg Nurs. 1997;23:83–4.

    Article  CAS  PubMed  Google Scholar 

  21. Roy B, Crawford R. Pitfalls in diagnosis and management of carbon monoxide poisoning. J Accid Emerg Med. 1996;9:62–3.

    Article  Google Scholar 

  22. Dolan MC, Haltom TL, Barrows GH, et al. Carboxyhemoglobin levels in patients with flu-like symptoms. Ann Emerg Med. 1987;16:782–6.

    Article  CAS  PubMed  Google Scholar 

  23. Fisher J, Rubin KP. Occult carbon monoxide poisoning. Arch Intern Med. 1982;142:1270–1.

    Article  CAS  PubMed  Google Scholar 

  24. Grace TW, Platt FW. Subacute carbon monoxide poisoning. JAMA. 1981;246:1698–700.

    Article  CAS  PubMed  Google Scholar 

  25. Heckerling PS, Leikin JB, Maturen A, et al. Predictors of occult carbon monoxide poisoning in patients with headache and dizziness. Ann Intern Med. 1987;107:174–6.

    Article  CAS  PubMed  Google Scholar 

  26. Heckerling PS, Leikin JB, Maturen A. Occult carbon monoxide poisoning: validation of a prediction model. Am J Med. 1988;84:251–6.

    Article  CAS  PubMed  Google Scholar 

  27. Heckerling PS, Leikin JB, Terzian CG, et al. Occult carbon monoxide poisoning in patients with neurologic illness. J Toxicol Clin Toxicol. 1990;28:29–44.

    Article  CAS  PubMed  Google Scholar 

  28. Kirkpatrick JN. Occult carbon monoxide poisoning. West J Med. 1987;146:52–6.

    CAS  PubMed  PubMed Central  Google Scholar 

  29. Cotton FA, Wilkinson G. Advanced inorganic chemistry: a comprehensive text. 3rd ed. New York: Wiley; 1972. p. 684–8.

    Google Scholar 

  30. Douglas CG, Haldane JS, Haldane JBS. The laws of combination of haemoglobin with carbon monoxide and oxygen. J Physiol Lond. 1912;44:275–304.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  31. Coburn RF, Forster RE, Kane PB. Considerations of the physiological variables that determine the blood carboxyhemoglobin concentration in man. J Clin Invest. 1910;44:1899–910.

    Article  Google Scholar 

  32. Hampson NB. Pulse oximetry in severe carbon monoxide poisoning. Chest. 1998;114:1036–41.

    Article  CAS  PubMed  Google Scholar 

  33. Salhany JM, Ogawa S, Shulman RG. Correlation between quaternary structure and ligand dissociation kinetics for fully liganded hemoglobin. Biochem J. 1975;14:2180–90.

    Article  CAS  Google Scholar 

  34. Collman JP, Brauman JI, Doxsee KM. Carbon monoxide binding to iron porphyrins. Proc Natl Acad Sci U S A. 1979;76:6035–9.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  35. Sharma VS, John ME, Waterman MR. Functional studies on hemoglobin opossum. J Biol Chem. 1982;257:11887–92.

    CAS  PubMed  Google Scholar 

  36. Lim M, Jackson TA, Anfinrud PA. Ultrafast rotation and trapping of carbon monoxide dissociated from myoglobin. Nat Struct Biol. 1997;4:209–14.

    Article  CAS  PubMed  Google Scholar 

  37. Thom SR, Ohnishi ST, Ischiropoulos H, et al. Nitric oxide released by platelets inhibits neutrophil B2 integrin function following acute carbon monoxide poisoning. Toxicol Appl Pharmacol. 1994;128:105–10.

    Article  CAS  PubMed  Google Scholar 

  38. Thom SR, Ischiropoulos H. Mechanism of oxidative stress from low levels of carbon monoxide, Health Effect Institute Research Report 80. Cambridge, MA: Health Effect Institute; 1997.

    Google Scholar 

  39. Thom SR, Xu YA, Ischiropoulos H. Vascular endothelial cells generate peroxynitrite in response to carbon monoxide exposure. Chem Res Toxicol. 1997;10:1023–31.

    Article  CAS  PubMed  Google Scholar 

  40. Ischiropoulos H, Beers MF, Ohnishi ST, et al. Nitric oxide and perivascular tyrosine nitration following carbon monoxide poisoning in the rat. J Clin Invest. 1996;97:2260–7.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  41. Thom SR, Ohnishi ST, Fisher D, et al. Pulmonary vascular stress from carbon monoxide. Toxicol Appl Pharmacol. 1999;154:12–9.

    Article  CAS  PubMed  Google Scholar 

  42. Thom SR, Fisher D, Xu YA, et al. Role of nitric oxide-derived oxidants in vascular injury from carbon monoxide in the rat. Am J Physiol. 1999;276:H984–92 (Heart Circ Physiol 45).

    CAS  PubMed  Google Scholar 

  43. Thom SR, Fisher D, Xu YA, et al. Adaptive responses and apoptosis in endothelial cells exposed to carbon monoxide. Proc Natl Acad Sci U S A. 2000;97:1305–10.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  44. Thom SR. Carbon monoxide-mediated brain lipid peroxidation in the rat. J Appl Physiol. 1990;68:997–1003.

    CAS  PubMed  Google Scholar 

  45. Thom SR. Dehydrogenase conversion to oxidase and lipid peroxidation in brain after carbon monoxide poisoning. J Appl Physiol. 1992;73:1584–9.

    CAS  PubMed  Google Scholar 

  46. Thom SR. Leukocytes in carbon monoxide-mediated brain oxidative injury. Toxicol Appl Pharmacol. 1993;123:234–47.

    Article  CAS  PubMed  Google Scholar 

  47. Verma A, Hirsch DJ, Glatt CE, et al. Carbon monoxide: a putative neural messenger. Science. 1993;259:381–4.

    Article  CAS  PubMed  Google Scholar 

  48. Zhuo M, Small SA, Kandel ER, et al. Nitric oxide and carbon monoxide produce activity-dependent long-term synaptic enhancement in hippocampus. Science. 1993;260:1946–50.

    Article  CAS  PubMed  Google Scholar 

  49. Gibson QH, Olson JS, McKinnie RE, et al. A kinetic description of ligand binding to sperm whale myoglobin. J Biol Chem. 1986;261:10228–39.

    CAS  PubMed  Google Scholar 

  50. Coburn RF. The carbon monoxide body stores. Ann N Y Acad Sci. 1970;174:11–22.

    Article  CAS  PubMed  Google Scholar 

  51. Gothert M, Lutz F, Malorny G. Carbon monoxide partial pressure in tissue of different animals. Environ Res. 1970;3:303–9.

    Article  CAS  PubMed  Google Scholar 

  52. Schmidt HHHW, Nau H, Wittfoht W, et al. Arginine is a physiological precursor of endothelium-derived nitric oxide. Eur J Pharmacol. 1988;154:213–6.

    Article  CAS  PubMed  Google Scholar 

  53. Goda N, Suzuki K, Naito M, et al. Distribution of heme oxygenase isoforms in rat liver. J Clin Invest. 1998;101:604–12.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  54. Bernard C. An introduction to the study of experimental medicine. New York: HC Greene Dover Publications; 1865. 1957 reprint.

    Google Scholar 

  55. Haldane J. The action of carbonic oxide on man. J Physiol. 1895;18:430–62.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  56. Anderson EW, Andelman RJ, Strauch JM, et al. Effects of low-level carbon monoxide exposure on onset and duration of angina pectoris. Ann Intern Med. 1973;79:46–50.

    Article  CAS  PubMed  Google Scholar 

  57. Cramlet SH, Erickson HH, Gorman HA. Ventricular function following acute carbon monoxide exposure. J Appl Physiol. 1975;39:482–6.

    CAS  PubMed  Google Scholar 

  58. Ginsberg MD. Carbon monoxide intoxication: clinical features, neuropathology and mechanisms of injury. Clin Toxicol. 1985;23:281–8.

    CAS  Google Scholar 

  59. Choi S. Delayed neurologic sequelae in carbon monoxide intoxication. Arch Neurol. 1983;40:433–5.

    Article  CAS  PubMed  Google Scholar 

  60. Funata N, Okeda R, Takano T, et al. Electron microscopic observations of experimental carbon monoxide encephalopathy in the acute phase. Acta Pathol Jpn. 1982;32:219–29.

    CAS  PubMed  Google Scholar 

  61. Garland H, Pearce J. Neurological complications of carbon monoxide poisoning. QJM. 1967;144:445–55.

    Google Scholar 

  62. Klees M, Heremans M, Doughan S. Psychological sequelae to carbon monoxide poisoning in the child. J Toxicol Clin Exp. 1985;5:301–7.

    CAS  PubMed  Google Scholar 

  63. Myers RAM, Snyder SK, Emhoff TA. Subacute sequelae of carbon monoxide poisoning. Ann Emerg Med. 1985;14:1163–7.

    Article  CAS  PubMed  Google Scholar 

  64. Okeda R, Funata N, Song SJ, et al. Comparative study pathogenesis of selective cerebral lesions in carbon monoxide poisoning and nitrogen hypoxia in cats. Acta Neuropathol. 1982;56:265–72.

    Article  CAS  PubMed  Google Scholar 

  65. Thom SR, Taber RL, Mendiguren II, et al. Delayed neuropsychologic sequelae after carbon monoxide poisoning: prevention by treatment with hyperbaric oxygen. Ann Emerg Med. 1995;25:474–80.

    Article  CAS  PubMed  Google Scholar 

  66. Winter PM, Miller JN. Carbon monoxide poisoning. JAMA. 1976;236:1502–4.

    Article  CAS  PubMed  Google Scholar 

  67. Gorman DF, Clayton D, Gilligan JE, et al. A longitudinal study of 100 consecutive admissions for carbon monoxide poisoning to the Royal Adelaide Hospital. Anaesth Intensive Care. 1992;20:311–6.

    CAS  PubMed  Google Scholar 

  68. Mathieu D, Wattel F, Mathieu-Nolf M, et al. Randomized prospective study comparing the effect of HBO versus 12 hours NBO in non-comatose CO poisoned patients. Undersea Hyperb Med. 1996;23(Suppl):7.

    Google Scholar 

  69. Raphael JC, Elkharrat D, Guincestre MCJ, et al. Trial of normobaric and hyperbaric oxygen for acute carbon monoxide intoxication. Lancet. 1989;2:414–9.

    Article  CAS  PubMed  Google Scholar 

  70. Schulte JH. Effects of mild carbon monoxide intoxication. Arch Environ Health. 1969;7:524–30.

    Article  Google Scholar 

  71. Remick RA, Miles JE. Carbon monoxide poisoning: neurologic and psychiatric sequelae. Can Med Assoc J. 1977;117:654–7.

    CAS  PubMed  PubMed Central  Google Scholar 

  72. Ryan CM. Memory disturbances following chronic low level carbon monoxide exposure. Arch Clin Neuropsychol. 1990;5:59–67.

    Article  CAS  PubMed  Google Scholar 

  73. Jiang J, Tyssebotn I. A model for acute carbon monoxide poisoning in conscious rats. Undersea Hyperb Med. 1996;23:99–106.

    CAS  PubMed  Google Scholar 

  74. Jiang J, Tyssebotn I. Normobaric and hyperbaric oxygen treatment of acute carbon monoxide poisoning in rats. Undersea Hyperb Med. 1997;24:107–16.

    CAS  PubMed  Google Scholar 

  75. Brown SD, Piantadosi CA. Reversal of carbon monoxide-cytochrome C oxidase binding by hyperbaric oxygen in vivo. Adv Exp Biol Med. 1989;248:747–54.

    Article  CAS  Google Scholar 

  76. Brown SD, Piantadosi CA. Recovery of energy metabolism in rat brain after carbon monoxide hypoxia. J Clin Invest. 1991;89:666–72.

    Article  Google Scholar 

  77. Mayevsky A, Meilin S, Rogatsky GG, et al. Multiparametric monitoring of the awake brain exposed to carbon monoxide. J Appl Physiol. 1995;78:1188–96.

    CAS  PubMed  Google Scholar 

  78. Coburn RF, Wallace HW, Abboud R. Redistribution of body carbon monoxide after hemorrhage. Am J Physiol. 1971;220:868–74.

    CAS  PubMed  Google Scholar 

  79. Piantadosi CA, Zhang J, Demchenko IT. Production of hydroxyl radical in the hippocampus after CO hypoxia or hypoxic hypoxia in the rat. Free Radic Biol Med. 1997;22:725–32.

    Article  CAS  PubMed  Google Scholar 

  80. Bogusz M, Cholewa L, Pach J, et al. A comparison of two types of carbon monoxide poisoning. Arch Toxicol. 1975;33:141–9.

    Article  CAS  PubMed  Google Scholar 

  81. Min SK. A brain syndrome associated with delayed neuropsychiatric sequelae following acute carbon monoxide intoxication. Acta Psychiatr Scand. 1986;73:80–6.

    Article  CAS  PubMed  Google Scholar 

  82. Smith JS, Brandon S. Morbidity from acute carbon monoxide poisoning at three-year follow-up. BMJ. 1973;1:318–21.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  83. Wasowski J, Myslak Z, Graczyk M, et al. An attempt at comparing the results of carboxyhemoglobin level in blood and gasometric determination in capillary blood in cases of carbon monoxide poisoning when treatment began at the place of accident. Anaesth Resusc Intensive Ther. 1976;4:245–9.

    Google Scholar 

  84. Werner B, Back W, Akerblom H, et al. Two cases of acute carbon monoxide poisoning with delayed neurological sequelae after a “free” interval. Clin Toxicol. 1985;23:249–65.

    CAS  Google Scholar 

  85. Piantadosi CA, Zhang J, Levin ED, et al. Apoptosis and delayed neuronal damage after carbon monoxide poisoning in the rat. Exp Neurol. 1997;147:103–14.

    Article  CAS  PubMed  Google Scholar 

  86. Kjeldsen K, Astrup P, Wanstrup J. Ultrastructural intimal changes in the rabbit aorta after a moderate carbon monoxide exposure. Atherosclerosis. 1972;16:67–82.

    Article  CAS  PubMed  Google Scholar 

  87. Maurer FW. The effects of carbon monoxide anoxemia on the flow and composition of cervical lymph. Am J Physiol. 1941;133:170–9.

    CAS  Google Scholar 

  88. Parving HH, Ohlsson K, Hansen HJB, et al. Effect of carbon monoxide exposure on capillary permeability to albumin and α2-macroglobulin. Scand J Clin Lab Invest. 1972;29:381–8.

    Article  CAS  PubMed  Google Scholar 

  89. Siggaard-Anderson J, Bonde-Peterson F, Hanson TI. Plasma volume and vascular permeability during hypoxia and carbon monoxide exposure. Scand J Clin Lab Invest. 1968;22:39–48.

    Article  Google Scholar 

  90. Fisher AB, Hyde RW, Baue AE, et al. Effect of carbon monoxide on function and structure of the lung. J Appl Physiol. 1969;26:4–12.

    CAS  PubMed  Google Scholar 

  91. Robinson NB, Barie PS, Halebian PH, et al. Distribution of ventilation and perfusion following acute carbon monoxide poisoning. Surg Forum. 1985;36:115–8.

    Google Scholar 

  92. Sugi K, Theissen JL, Traber LD, et al. Impact of carbon monoxide on cardiopulmonary dysfunction after smoke inhalation injury. Circ Res. 1990;66:69–75.

    Article  CAS  PubMed  Google Scholar 

  93. Meilin S, Rogatsky GG, Thom SR, et al. Effects of carbon monoxide on the brain may be mediated by nitric oxide. J Appl Physiol. 1996;81:1078–83.

    CAS  PubMed  Google Scholar 

  94. Von Andrian UH, Chambers JD, McEvoy LM, et al. Two-step model of leukocyte-endothelial cell interaction in inflammation: distinct roles for LECAM-1 and the leukocyte β2 integrins in vivo. Proc Natl Acad Sci U S A. 1991;88:7538–42.

    Article  Google Scholar 

  95. Thom SR. Antagonism of CO-mediated brain lipid peroxidation by hyperbaric oxygen. Toxicol Appl Pharmacol. 1990;105:340–4.

    Article  CAS  PubMed  Google Scholar 

  96. Thom SR. Functional inhibition of leukocyte β2 integrins by hyperbaric oxygen in carbon monoxide-mediated brain injury in rats. Toxicol Appl Pharmacol. 1993;123:248–56.

    Article  CAS  PubMed  Google Scholar 

  97. Banick PD, Chen Q, Xu YA, et al. Nitric oxide inhibits neutrophil β2 integrin function by inhibiting membrane-associated cyclic GMP synthesis. J Cell Physiol. 1997;172:12–24.

    Article  CAS  PubMed  Google Scholar 

  98. Thom SR. Learning dysfunction and metabolic defects in globus pallidus and hippocampus after CO poisoning in a rat model. Undersea Hyperb Med. 1997;23(Suppl):20.

    Google Scholar 

  99. Thom SR, Xu YA, Fisher DG. Autoimmune responses in carbon monoxide-mediated brain injury. Undersea Hyperb Med Winter. 2000;27(4).

    Google Scholar 

  100. Jiang J, Tyssebotn I. Cerebrospinal fluid pressure changes after acute carbon monoxide poisoning and therapeutic effects of normobaric and hyperbaric oxygen in conscious rats. Undersea Hyperb Med. 1997;24:245–54.

    CAS  PubMed  Google Scholar 

  101. Tomaszewski C, Rudy J, Wathen J, et al. Prevention of neurologic sequelae from carbon monoxide by hyperbaric oxygen in rats. Ann Emerg Med. 1992;21:631–2.

    Article  Google Scholar 

  102. Nabeshima T, Katoh A, Ishimaru H, et al. Carbon monoxide-induced delayed amnesia, delayed neuronal death and change in acetylcholine concentration in mice. J Pharmacol Exp Ther. 1991;256:378–84.

    CAS  PubMed  Google Scholar 

  103. Ishimaru H, Nabeshima T, Katoh A, et al. Effects of successive carbon monoxide exposures on delayed neuronal death in mice under the maintenance of normal body temperature. Biochem Biophys Res Commun. 1991;179:836–40.

    Article  CAS  PubMed  Google Scholar 

  104. Choi DW. Calcium-mediated neurotoxicity: relationship to specific channel types and role in ischemic damage. Trends Neurosci. 1988;11:465–79.

    Article  CAS  PubMed  Google Scholar 

  105. Mayer ML, Miller RJ. Excitatory amino acid receptors, second messengers and regulation of intracellular Ca2+ in mammalian neurons. Trends Neurosci. 1990;11:254–60.

    CAS  Google Scholar 

  106. Ishimaru H, Katoh A, Suzuki H, et al. Effects of N-methyl-d-aspartate receptor antagonists on carbon monoxide-induced brain damage in mice. J Pharmacol Exp Ther. 1992;261:349–52.

    CAS  PubMed  Google Scholar 

  107. Liu Y, Fechter LD. MK-801 protects against carbon monoxide-induced hearing loss. Toxicol Appl Pharmacol. 1995;132:196–202.

    Article  CAS  PubMed  Google Scholar 

  108. Newby MB, Roberts RJ, Bhatnagar RK. Carbon monoxide and hypoxia-induced effects on catecholamines in the mature and developing rat brain. J Pharmacol Exp Ther. 1978;206:61–8.

    CAS  PubMed  Google Scholar 

  109. Bindoli A, Rigobello MP, Deeble DJ. Biochemical and toxicological properties of the oxidation products of catecholamines. Free Radic Biol Med. 1992;13:391–405.

    Article  CAS  PubMed  Google Scholar 

  110. Piantadosi CA, Tatro L, Zhang J. Hydroxyl radical production in the brain after CO hypoxia in rats. Free Radic Biol Med. 1995;18:603–9.

    Article  CAS  PubMed  Google Scholar 

  111. Levitt P, Pintar JE, Breakfield XO. Immunocytochemical demonstration of monoamine oxidase B in brain astrocytes and serotonergic neurons. Proc Natl Acad Sci U S A. 1982;79:6385–9.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  112. Reiderer P, Konradi C, Schay V, et al. Localization of MAO-A and MAO-B in human brain: a step in understanding the therapeutic action of L-deprenyl. Adv Neurol. 1986;45:111–8.

    Google Scholar 

  113. Hanbauer I, Wink D, Osawa Y, et al. Role of nitric oxide in NMDA-evoked release of [3H]-dopamine from striatal slices. Neuroreport. 1992;3:409–12.

    Article  CAS  PubMed  Google Scholar 

  114. Montague PR, Gancayco CD, Winn MJ, et al. Role of NO production in NMDA receptor-mediated neurotransmitter release in cerebral cortex. Science. 1994;263:973–7.

    Article  CAS  PubMed  Google Scholar 

  115. Chao CC, Hu S, Molitor TW, et al. Activated microglia mediate neuronal cell injury via a nitric oxide mechanism. J Immunol. 1992;149:2736–41.

    CAS  PubMed  Google Scholar 

  116. Merrill JE, Zimmerman RP. Natural and induced cytotoxicity of oligodendrocytes by microglia is inhibitable by TBFβ. Glia. 1991;4:327–31.

    Article  CAS  PubMed  Google Scholar 

  117. Lapresle J, Fardeau M. The central nervous system and carbon monoxide poisoning. In: Bour H, Ledingham IM, editors. Carbon monoxide poisoning. Amsterdam: Elsevier; 1967. p. 31–74.

    Chapter  Google Scholar 

  118. Courville CB. The process of demyelination in the central nervous system. J Nerv Ment Dis. 1957;125:504–46.

    Article  Google Scholar 

  119. Putnam TJ, McKenna JB, Morrison LR. Studies in multiple sclerosis. JAMA. 1991;97:1591–6.

    Article  Google Scholar 

  120. Bianco F, Floris R. Transient disappearance of bilateral low-density lesions of the globi pallidi in carbon monoxide intoxication and MRI. J Neuroradiol. 1988;15:381–5.

    CAS  PubMed  Google Scholar 

  121. DeReuck J, Deccoo D, Lemahieu I, et al. A positron emission tomography study of patients with acute carbon monoxide poisoning treated by hyperbaric oxygen. J Neurol. 1993;240:430–4.

    Article  CAS  Google Scholar 

  122. Ducasse JL, Celsis P, Marc-Vergnes JP. Non-comatose patients with acute carbon monoxide poisoning: hyperbaric or normobaric oxygenation? Undersea Hyperb Med. 1995;22:9–15.

    CAS  PubMed  Google Scholar 

  123. Maeda Y, Kawasaki Y, Jibiki I, et al. Effect of therapy with oxygen under high pressure on regional cerebral blood flow in the interval form of carbon monoxide poisoning: observation from subtraction of technetium-99m HMPAO SPECT brain imaging. Eur Neurol. 1991;31:380–3.

    Article  CAS  PubMed  Google Scholar 

  124. Shimosegawa E, Hatazawa J, Nagata K, et al. Cerebral blood flow and glucose metabolism measurements in a patient surviving one year after carbon monoxide intoxication. J Nucl Med. 1992;33:1696–8.

    CAS  PubMed  Google Scholar 

  125. Silverman CS, Brenner J, Murtagh FR. Hemorrhagic necrosis and vascular injury in carbon monoxide poisoning: MR demonstration. AJNR Am J Neuroradiol. 1993;14:168–70.

    CAS  PubMed  Google Scholar 

  126. Song SY, Okeda R, Funata N, et al. An experimental study of the pathogenesis of the selective lesion of the globus pallidus in acute carbon monoxide poisoning in cats. Acta Neuropathol. 1983;61:232–8.

    Article  CAS  PubMed  Google Scholar 

  127. Lee D, Hsu TL, Chen CH, et al. Myocardial infarction with normal coronary artery after carbon monoxide exposure: a case report. Chin Med J. 1996;57:355–9.

    CAS  Google Scholar 

  128. Marius-Nunez AL. Myocardial infarction with normal coronary arteries after acute exposure to carbon monoxide. Chest. 1990;97:491–4.

    Article  CAS  PubMed  Google Scholar 

  129. Mathieu D, Wattel F. Oxygenotherapie hyperbare et intoxications. In: Wattel F, Mathieu D, editors. Oxygenotherapie Hyperbare et Reanimation. Paris: Masson; 1990. p. 129–43.

    Google Scholar 

  130. Uchino A, Hasuo K, Shida K, et al. MRI of the brain in chronic carbon monoxide poisoning. Neuroradiology. 1994;36:399–401.

    Article  CAS  PubMed  Google Scholar 

  131. Vieregge P, Klostermann W, Blumm RG, et al. Carbon monoxide poisoning: clinical, neurophysiological, and brain imaging observations in acute disease and follow-up. J Neurol. 1989;236:478–81.

    Article  CAS  PubMed  Google Scholar 

  132. Murata T, Itoh S, Koshino Y, et al. Serial cerebral MRI with FLAIR sequences in acute carbon monoxide poisoning. J Comput Assist Tomogr. 1995;19:631–4.

    Article  CAS  PubMed  Google Scholar 

  133. Sakamoto K, Murata T, Omori M, et al. Clinical studies on three cases of the interval form of carbon monoxide poisoning: serial proton magnetic resonance spectroscopy as a prognostic predictor. Psychiatry Res Neuroimaging Sect. 1998;83:179–92.

    Article  CAS  Google Scholar 

  134. Yoshii F, Kozuma R, Takahashi W, et al. Magnetic resonance imaging and 11C-N-methylspiperone/positron emission tomography studies in a patient with the interval form of carbon monoxide poisoning. J Neurol Sci. 1998;160:87–91.

    Article  CAS  PubMed  Google Scholar 

  135. Thom SR, Kang M, Fisher D, et al. Release of glutathione from erythrocytes and other markers of oxidative stress in carbon monoxide poisoning. J Appl Physiol. 1997;82:1424–32.

    CAS  PubMed  Google Scholar 

  136. Pace N, Strajman E, Walker EL. Acceleration of carbon monoxide elimination in man by high pressure oxygen. Science. 1950;111:652–4.

    Article  CAS  PubMed  Google Scholar 

  137. Peterson JE, Stewart RD. Absorption and elimination of carbon monoxide by inactive young men. Arch Environ Health. 1970;21:165–71.

    Article  CAS  PubMed  Google Scholar 

  138. Weaver LK, Howe S, Hopkins R, et al. Carboxyhemoglobin half-life in carbon monoxide-poisoned patients treated with 100% oxygen at atmospheric pressure. Chest. 2000;117:801–8.

    Article  CAS  PubMed  Google Scholar 

  139. Mathieu D, Nolf M, Durocher A, et al. Acute carbon monoxide poisoning risk of late sequelae and treatment by hyperbaric oxygen. J Toxicol Clin Toxicol. 1985;23:315–24.

    Article  CAS  PubMed  Google Scholar 

  140. Goulon M, Barois A, Rapin M, et al. Carbon monoxide poisoning and acute anoxia due to breathing coal gas and hydrocarbons. Ann Med Interne. 1969;120:335–49 [English translation in J Hyperb Med 1986;1:23–41].

    CAS  Google Scholar 

  141. Hsu LH, Wang JH. Treatment of carbon monoxide poisoning with hyperbaric oxygen. Chin Med J. 1996;58:407–13.

    CAS  Google Scholar 

  142. Lamy M, Hauguet M. Fifty patients with carbon monoxide intoxication treated with hyperbaric oxygen therapy. Acta Anaesthesiol Belg. 1969;1:49–53.

    Google Scholar 

  143. Norkool DM, Kirkpatrick JN. Treatment of acute carbon monoxide poisoning with hyperbaric oxygen: a review of 115 cases. Ann Emerg Med. 1985;14:1168–71.

    Article  CAS  PubMed  Google Scholar 

  144. Roche L, Bertoye A, Vincent P, et al. Comparison de deux groupes de vingt intoxications oxycarbonees traitees par oxygenenormobare et hyperbare. Lyon Med. 1968;49:1483–99.

    Google Scholar 

  145. End E, Long CW. Oxygen under pressure in carbon monoxide poisoning. J Ind Hyg Toxicol. 1942;24:302–6.

    CAS  Google Scholar 

  146. Boerema I, Meyne I, Brummelkamp WH, et al. Life without blood. Arch Chir Neer. 1959;11:70–83.

    Google Scholar 

  147. Chen Q, Banick PD, Thom SR. Functional inhibition of rat polymorphonuclear leukocyte B2 integrins by hyperbaric oxygen is associated with impaired cGMP synthesis. J Pharmacol Exp Ther. 1996;276:929–33.

    CAS  PubMed  Google Scholar 

  148. Thom SR, Mendiguren I, Hardy KR, et al. Inhibition of human neutrophil β2 integrin-dependent adherence by hyperbaric oxygen. Am J Physiol. 1997;272:770–1.

    Google Scholar 

  149. Hampson NB, Little CE. Hyperbaric treatment of patients with carbon monoxide poisoning in the United States. Undersea Hyperb Med. 2005;32:21–6.

    CAS  PubMed  Google Scholar 

  150. Hampson NB, Dunford RG, Kramer CC, et al. Selection criteria utilized for hyperbaric oxygen treatment of carbon monoxide poisoning. J Emerg Med. 1995;13:227–31.

    Article  CAS  PubMed  Google Scholar 

  151. Waisman D, Shupak A, Weisz G, et al. Hyperbaric oxygen therapy in the pediatric patient: the experience of the Israel Naval Medical Institute. Pediatrics. 1998;102:1–9.

    Article  Google Scholar 

  152. Scheinkestel CD, Bailey M, Myles PS, et al. Hyperbaric or normobaric oxygen for acute carbon monoxide: a randomized controlled clinical trial. Med J Aust. 1999;170:203–10.

    CAS  PubMed  Google Scholar 

  153. Kehat I, Shupak A. Letter. Undersea Biomed Res. 2000;27:43.

    Google Scholar 

  154. Annane D, Chadda K, Gajdos P, Jars-Guincestre M-C, Chevret S, Raphael J-C. Hyperbaric oxygen for acute domestic carbon monoxide poisoning: two randomized controlled trials. Intensive Care Med. 2011;37:486–92.

    Article  CAS  PubMed  Google Scholar 

  155. Buckley NA, Juurlink DN, Isbister G, Bennett MH, Lavonas EJ. Hyperbaric oxygen for carbon monoxide poisoning. Cochrane Database Syst Rev. 2011;4, CD002041. doi:10.1002/14651858.CD002041.pub3.

    Google Scholar 

  156. Weaver LK, Hopkins RO, Chan KJ, et al. Hyperbaric oxygen for acute carbon monoxide poisoning. N Engl J Med. 2002;347:1057–67.

    Article  CAS  PubMed  Google Scholar 

  157. Okeda R, Runata N, Takano T, et al. The pathogenesis of carbon monoxide encephalopathy in the acute phase – physiological and morphological conditions. Acta Neuropathol. 1981;54:1–10.

    Article  CAS  PubMed  Google Scholar 

  158. Sokal JA, Kralkowska E. The relationship between exposure duration, carboxyhemoglobin, blood glucose, pyruvate and lactate and the severity of intoxication in 39 cases of acute carbon monoxide poisoning in man. Arch Toxicol. 1985;57:196–9.

    Article  CAS  PubMed  Google Scholar 

  159. Turner M, Esaw M, Clark RJ. Carbon monoxide poisoning treated with hyperbaric oxygen: metabolic acidosis as a predictor of treatment requirements. J Acad Emerg Med. 1999;16:96–8.

    Article  CAS  Google Scholar 

  160. Pepe G, Castelli M, Nazerian P, et al. Delayed neurological sequelae after carbon monoxide poisoning: predictive risk factors in the Emergency Department. A retrospective study. Scan J Trauma Resusc Emerg Med. 2011;19(16):1–8.

    Google Scholar 

  161. Hampson NB, Zmaeff JL. Outcome of patients experiencing cardiac arrest with carbon monoxide poisoning treated with hyperbaric oxygen. Ann Emerg Med. 2001;38:36–41.

    Article  CAS  PubMed  Google Scholar 

  162. Sloan EP, Murphy DG, Hart R, et al. Complications and protocol considerations in carbon monoxide-poisoned patients who require hyperbaric oxygen therapy: report from a ten-year experience. Ann Emerg Med. 1989;18:629–34.

    Article  CAS  PubMed  Google Scholar 

  163. Kindwall EP, editor. Hyperbaric medicine practice. Flagstaff: Best Publishing; 1994.

    Google Scholar 

  164. Stone JA, Loar H, Rudge FW. An eleven year review of hyperbaric oxygenation in a military clinical setting. Undersea Biomed Res. 1991;18(Suppl):80.

    Google Scholar 

  165. Clark JM. Oxygen toxicity. In: Bennett PB, Elliott DH, editors. The physiology and medicine of diving. 4th ed. Philadelphia: WB Saunders; 1993. p. 121–69.

    Google Scholar 

  166. Pott F, Westergaard P, Mortensen J, et al. Hyperbaric oxygen treatment and pulmonary function. Undersea Hyperb Med. 1999;26:225–8.

    CAS  PubMed  Google Scholar 

  167. Thorsen E, Aanderud L, Aasen TB. Effects of a standard hyperbaric oxygen treatment protocol on pulmonary function. Eur Respir J. 1998;12:1442–5.

    Article  CAS  PubMed  Google Scholar 

  168. Plewes JL, Farhi LE. Peripheral circulatory responses to acute hyperoxia. Undersea Biomed Res. 1983;10:123–9.

    CAS  PubMed  Google Scholar 

  169. Comis RL. Bleomycin pulmonary toxicity: current status and future directions. Semin Oncol. 1992;19:64–70.

    CAS  PubMed  Google Scholar 

  170. Lazo JS, Sebati SM, Schellens JH. Bleomycin. Cancer Chemother Biol Response Modif. 1996;16:39–47.

    CAS  PubMed  Google Scholar 

  171. Copel JA, Bowen F, Bolognese RJ. Carbon monoxide intoxication in early pregnancy. Obstet Gynecol. 1982;59(Suppl):26S–8.

    CAS  PubMed  Google Scholar 

  172. Caravati EM, Adams CJ, Joyce SM, et al. Fetal toxicity associated with maternal carbon monoxide poisoning. Ann Emerg Med. 1988;17:714–7.

    Article  CAS  PubMed  Google Scholar 

  173. Elkharrat D, Raphael JC, Korach JM, et al. Acute carbon monoxide intoxication and hyperbaric oxygen in pregnancy. Intensive Care Med. 1991;17:289–92.

    Article  CAS  PubMed  Google Scholar 

  174. Ivanov KP, Samsonov GV, Bogomolova LG, Moiseeva OI, Chuikin AE. Oxygen transport in rats following total blood replacement with solutions of high-molecular modified hemoglobin. Fiziol Zh SSSR Im I M Sechenova. 1981;67(12):1814–22.

    CAS  PubMed  Google Scholar 

  175. Ginsberg MD, Myers RE. Fetal brain injury after maternal carbon monoxide intoxication. Neurology. 1976;26:15–23.

    Article  CAS  PubMed  Google Scholar 

  176. Norman CA, Halton DM. Is carbon monoxide a workplace teratogen? A review and evaluation of the literature. Ann Occup Hyg. 1990;34:335–47.

    Article  CAS  PubMed  Google Scholar 

  177. Longo LD, Hill EP. Carbon monoxide uptake and elimination in fetal and maternal sheep. Am J Physiol. 1977;232:H324–30.

    CAS  PubMed  Google Scholar 

  178. Koren G, Sharav T, Pastuszak A, et al. A multicenter, prospective study of fetal outcome following accidental carbon monoxide poisoning in pregnancy. Reprod Toxicol. 1991;5:397–403.

    Article  CAS  PubMed  Google Scholar 

  179. Brown DB, Mueller GL, Golich FC. Hyperbaric oxygen treatment for carbon monoxide poisoning in pregnancy: a case report. Aviat Space Environ Med. 1992;63:1011–4.

    CAS  PubMed  Google Scholar 

  180. Gabrielli A, Layon AJ. Carbon monoxide intoxication during pregnancy: a case presentation and pathophysiologic discussion, with emphasis on molecular mechanisms. J Clin Anesth. 1995;14:876–82.

    Google Scholar 

  181. Hollander DI, Nagey DA, Welch R, et al. Hyperbaric oxygen therapy for the treatment of acute carbon monoxide poisoning in pregnancy: a case report. J Reprod Med. 1987;32:615–7.

    CAS  PubMed  Google Scholar 

  182. Ledingham IM, McBride TI, Jennett WB, et al. Fatal brain damage associated with cardiomyopathy of pregnancy with notes on caesarean section in a hyperbaric chamber. BMJ. 1968;4:285–7.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  183. VanHoesen KB, Camporesi EM, Moon RE, et al. Should hyperbaric oxygen be used to treat the pregnant patient for acute carbon monoxide poisoning. JAMA. 1989;261:1039–43.

    Article  CAS  Google Scholar 

  184. Cho SH, Yun DR. The experimental study on the effect of hyperbaric oxygen on the pregnancy wastage of rats with acute carbon monoxide poisoning. Seoul J Med. 1982;23:67–75.

    Google Scholar 

  185. Gilman SC, Greene KM, Bradley ME, et al. Fetal development: effects of simulated diving and hyperbaric oxygen treatment. Undersea Biomed Res. 1982;9:297–304.

    CAS  PubMed  Google Scholar 

  186. Jennings RT. Women and the hazardous environment: when the pregnant patient requires hyperbaric oxygen therapy. Aviat Space Environ Med. 1987;58:370–4.

    CAS  PubMed  Google Scholar 

  187. Crocker PJ, Walker JS. Pediatric carbon monoxide toxicity. J Emerg Med. 1985;3:443–8.

    Article  CAS  PubMed  Google Scholar 

  188. Foster M, Goodwin SR, Williams C, et al. Recurrent acute life-threatening events and lactic acidosis caused by chronic carbon monoxide poisoning in an infant. Pediatrics. 1999;104:34–9.

    Article  Google Scholar 

  189. Klasner AE, Smith SR, Thompson MW, et al. Carbon monoxide mass exposure in a pediatric population. Acad Emerg Med. 1998;5:992–6.

    Article  CAS  PubMed  Google Scholar 

  190. Gemelli F, Cattani R. Carbon monoxide poisoning in childhood. BMJ. 1985;291:1197.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  191. Binder JW, Roberts RJ. Carbon monoxide intoxication in children. Clin Toxicol. 1980;16:287–95.

    Article  CAS  PubMed  Google Scholar 

  192. Lacey DJ. Neurologic sequelae of acute carbon monoxide intoxication. Am J Dis Child. 1981;135:145–7.

    CAS  PubMed  Google Scholar 

  193. So GM, Kosofsky BE, Souther JF. Acute hydrocephalus following carbon monoxide poisoning. Pediatr Neurol. 1997;17:270–3.

    Article  CAS  PubMed  Google Scholar 

  194. Choi IS, Kim SK, Lee SS, Choi YC. Evaluation of outcome of delayed neurologic sequelae after carbon monoxide poisoning by technetium-99m hexamethylpropylene amine oxime brain single photon emission computed tomography. Eur Neurol. 1995;35:137–42.

    Article  CAS  PubMed  Google Scholar 

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Authors and Affiliations

  1. UC Denver, Aurora, CO, USA

    Christopher Hoyte

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  1. Christopher Hoyte
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Correspondence to Christopher Hoyte .

Editor information

Editors and Affiliations

  1. University of Colorado School of Medicine, Toxicology Associates, Denver, Colorado, USA

    Jeffrey Brent

  2. Office of New Drugs Drug Evaluation and Research, FDA, Silver Spring, Maryland, USA

    Keith Burkhart

  3. Clinical Toxicology, St Thomas' Hospital, London, United Kingdom

    Paul Dargan

  4. University of Colorado School of Medicine, Toxicology Associates, Denver, Colorado, USA

    Benjamin Hatten

  5. Med & Toxicological Intensive Care Unit, Lariboisière Hospital Paris-Diderot University, Paris, France

    Bruno Megarbane

  6. University of Colorado School of Medicine, Toxicology Associates, Denver, Colorado, USA

    Robert Palmer

Grading System for Levels of Evidence Supporting Recommendations in Critical Care Toxicology, 2nd Edition

Grading System for Levels of Evidence Supporting Recommendations in Critical Care Toxicology, 2nd Edition

  1. I

    Evidence obtained from at least one properly randomized controlled trial.

  2. II-1

    Evidence obtained from well-designed controlled trials without randomization.

  3. II-2

    Evidence obtained from well-designed cohort or case–control analytic studies, preferably from more than one center or research group.

  4. II-3

    Evidence obtained from multiple time series with or without the intervention. Dramatic results in uncontrolled experiments (such as the results of the introduction of penicillin treatment in the 1940s) could also be regarded as this type of evidence.

  5. III

    Opinions of respected authorities, based on clinical experience, descriptive studies and case reports, or reports of expert committees.

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Hoyte, C. (2016). Carbon Monoxide. In: Brent, J., Burkhart, K., Dargan, P., Hatten, B., Megarbane, B., Palmer, R. (eds) Critical Care Toxicology. Springer, Cham. https://doi.org/10.1007/978-3-319-20790-2_22-1

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