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Benign and Malignant Neoplasms of the Exocrine Pancreas

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Principles and Practice of Geriatric Surgery

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Abstract

The incidence of most benign and malignant tumors of the pancreas increases with age. A multidisciplinary approach is necessary to ensure appropriate treatment and optimize patient outcomes. Unfortunately, treatment disparities persist when compared with the general population as many patients are denied appropriate therapy based on advanced chronological age. Furthermore, elderly patients are often excluded from clinical trials despite the fact that they are more likely to be affected by these groups of tumors. There is growing evidence to suggest that age alone is not a reason to withhold potentially curative surgery or standard of care chemotherapy. However, several studies have reported increased risk of surgical complications and chemotherapeutic toxicity, which may be explained by the presence of additional comorbidities, frailty, poor functional status, and altered drug metabolism. Various tools, such as the comprehensive geriatric assessment, have been developed to guide clinicians in the management of these complex patients. In the following chapter, we discuss the multidisciplinary approach for diagnosis and management of benign and malignant pancreatic tumors with a focus on the role of surgical resection.

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Authors and Affiliations

  1. Department of Surgery, H. Lee Moffitt Cancer Center, Tampa, Florida, USA

    Danielle K. DePeralta

  2. Department of Surgery, Massachusetts General Hospital, Boston, Massachusetts, USA

    Keith D. Lillemoe

Authors
  1. Danielle K. DePeralta
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  2. Keith D. Lillemoe
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Correspondence to Danielle K. DePeralta .

Editor information

Editors and Affiliations

  1. Surgical Service, Yale University School of Medicine VA Connecticut Health Care System, West Haven, Connecticut, USA

    Ronnie A. Rosenthal

  2. SUNY Downstate School of Public Health, National Capital Region Johns Hopkins Medicine, Bethesda, Maryland, USA

    Michael E. Zenilman

  3. Center for Geriatric Surgery, Sinai Hospital of Baltimore, Baltimore, Maryland, USA

    Mark R. Katlic

Section Editor information

  1. Department of Surgery, University of Nebraska Medical Center, Omaha, NE, USA

    Jason Johanning

  2. Duke Medicine, Durham, NC, USA

    Sandhya Lagoo-Deenadayalan

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© 2017 Springer International Publishing Switzerland

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DePeralta, D.K., Lillemoe, K.D. (2017). Benign and Malignant Neoplasms of the Exocrine Pancreas. In: Rosenthal, R., Zenilman, M., Katlic, M. (eds) Principles and Practice of Geriatric Surgery. Springer, Cham. https://doi.org/10.1007/978-3-319-20317-1_58-1

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  • DOI: https://doi.org/10.1007/978-3-319-20317-1_58-1

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-20317-1

  • Online ISBN: 978-3-319-20317-1

  • eBook Packages: Springer Reference MedicineReference Module Medicine

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