Skip to main content

Vitamin D and Photoprotection

  • Living reference work entry
  • First Online:
  • 319 Accesses

Abstract

Vitamin D, which has a well-established key role in bone health, is currently at the forefront of discussions in the dermatology field due to recent evidence of its role in extra-skeletal health. Vitamin D is obtained mainly through sunlight, and many factors can influence the conversion of vitamin D to its active variant in the skin, including environmental factors such as geographic location, seasonality, and atmospheric characteristics and individual factors such as age, skin type, and lifestyle, among others. Debate concerning the effects of solar protection on cutaneous synthesis of vitamin D has emerged in recent years. A recent literature review emphasized that adequate levels of vitamin D are needed to prevent osteoporosis, falls, and fractures in the elderly population. Emerging data also point to its role in cardiovascular diseases, autoimmunity, and some types of cancer. The normal and regular use of sunscreen for adults has not been shown to decrease the cutaneous synthesis of vitamin D. The daily recommendations for vitamin D intake, published in 2010, were based on the skeletal effects of this vitamin. Oral ingestion through fortified food or vitamin D supplementation is recommended for patients who are not usually exposed to the sun in order to maintain adequate serum levels. Patients should not be discouraged from using sunscreen due to its well-established photoprotective and preventive effects. It is important that we know all of the factors involved in the production of vitamin D, so we can analyze each patient individually and clearly determine the ideal conduct for each case, without prejudice or harm.

This is a preview of subscription content, log in via an institution.

References

  • Aloia JF. African Americans, 25-hydroxyvitamin D and osteoporosis: a paradox. Am J Clin Nutr. 2008;88:535S–50S.

    Google Scholar 

  • Aloia JF, Li-Ng M, Pollack S. Statins and vitamin D. Am J Cardiol. 2007;100:1329.

    Article  PubMed  PubMed Central  Google Scholar 

  • Aloia JF, Li-Ng M. Re: epidemic influenza and vitamin D [letter]. Epidemiol Infect. 2007;135(7):1095–6.

    Article  PubMed  PubMed Central  Google Scholar 

  • Binkley N, Novotny R, Krueger D, Kawahara T, Daida YG, Lensmeyer G, et al. Low vitamin D status despite abundant sun exposure. J Clin Endocrinol Metab. 2007;92:2130–5.

    Article  CAS  PubMed  Google Scholar 

  • Binkley N, Ramamurthy R, Krueger D. Low vitamin D status: definition, prevalence, consequences, and correction. Endocrinol Metab Clin N Am. 2010;39:287–301.

    Article  CAS  Google Scholar 

  • Bischoff-Ferrari HA, Giovannuci E, Willeet WC, Dietrich T, Dawson-Hughes B. Estimation of optimal serum concentrations of 25-hydroxyvitamin D for multiple health outcomes. Am J Clin Nutr. 2006;84:18–28.

    CAS  PubMed  Google Scholar 

  • Bogaczewicz J, Karczmarewicz E, Pludowski P, Zabek J, Wozniacka A. Requirement for vitamin D supplementation in patients using photoprotection: variations in vitamin D levels and bone formation markers. Int J Dermatol. 2016; doi:10.1111/ijd.13024.

    Google Scholar 

  • Chiu YE, Havens PL, Siegel DH, et al. Serum 25-hydroxyvitamin D concentration does not correlate with atopic dermatitis severity. J Am Acad Dermatol. 2013;69:40–6.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Corrêa MP. Solar ultraviolet radiation: properties, characteristics and amounts observed in Brazil and South America. An Bras Dermatol. 2015;90(3):297–310.

    Article  PubMed Central  Google Scholar 

  • Darlington S, Williams G, Neale R, Frost C, Green A. A randomized controlled trial to assess sunscreen application and betacarotene supplementation in the prevention of solar keratoses. Arch Dermatol. 2003;139:451–5.

    Article  PubMed  Google Scholar 

  • Dattani JT, Exton-Smith AN, Stephen JM. Vitamin D status of the elderly in relation to age and exposure to sunlight. Hum Nutr Clin Nutr. 1984;38:131–7.

    CAS  PubMed  Google Scholar 

  • De Paula CM, Ceballos JC. Solar ultraviolet radiation measurements in one of the most populous cities of the world: aspects related to skin cancer cases and vitamin D availability. Photochem Photobiol. 2010;86(2):438–44.

    Article  Google Scholar 

  • Dobs AS, Levine MA, Margolis S. Effects of pravastatin, a new HMG-CoA reductase inhibitor, on vitamin D synthesis in man. Metabolism. 1991;40:524–8.

    Article  CAS  PubMed  Google Scholar 

  • Dunnigan MG, Paton JP, Haase S, McNicol GW, Gardner MD, Smith CM. Late rickets and osteomalacia in the Pakistani community in Glasgow. Scott Med J. 1962;7:159–67.

    Article  CAS  PubMed  Google Scholar 

  • Engelsen O, Brustad M, Aksnes L, Lund E. Daily duration of vitamin D synthesis in human skin with relation to latitude, total ozone, altitude, ground cover, aerosols and cloud thickness. Photochem Photobiol. 2005;81:1287–90.

    Article  CAS  PubMed  Google Scholar 

  • Fioletov VE, McArthur LJ, Mathews TW, Marrett L. On the relationship between erythemal and vitamin D action spectrum weighted ultraviolet radiation. J Photochem Photobiol B. 2009;95:9–16.

    Article  CAS  PubMed  Google Scholar 

  • Gambichler T, Hatch KL, Avermaete A, Altmeyer P, Hoffman K. Influence of wetness on the ultraviolet protection factor (UPF) of textiles: in vitro and in vivo measurements. Photodermatol Photoimmunol Photomed. 2002;18:29–35.

    Article  PubMed  Google Scholar 

  • Gilchrest BA. Sun exposure and vitamin D sufficiency. Am J Clin Nutr. 2008;88:570S–7S.

    CAS  PubMed  Google Scholar 

  • Ginde AA, Liu MC, Camargo Jr CA. Demographic differences and trends of vitamin D insufficiency in the US population, 1988-2004. Arch Intern Med. 2009;169:626–32.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Glass D, Lens M, Swaminathan R, Spector TD, Bataille V. Pigmentation and vitamin D metabolism in Caucasians: low vitamin D serum levels in fair skin types in the UK. PLoS One. 2009;4:e6477.

    Article  PubMed  PubMed Central  Google Scholar 

  • Godar DE, Wengraitis SP, Shreffler J, Sliney DH. UV doses of Americans. Photochem Photobiol. 2001;73:621–9.

    Article  CAS  PubMed  Google Scholar 

  • Grant WB. An estimate of premature cancer mortality in the U.S. due to inadequate doses of solar ultraviolet-B radiation. Cancer. 2002;94:1867–75.

    Article  PubMed  Google Scholar 

  • Hodgkin P, Kay GH, Hine PM, Lumb GA, Stanbury SW. Vitamin D deficiency in Asians at home and in Britain. Lancet. 1973;2:167–71.

    Article  CAS  PubMed  Google Scholar 

  • Holick MF. Environmental factors that influence the cutaneous production of vitamin D. Am J Clin Nutr. 1995;61:638S–45S.

    CAS  PubMed  Google Scholar 

  • Holick MF. Vitamin D deficiency. N Engl J Med. 2007;357:266–81.

    Article  CAS  PubMed  Google Scholar 

  • Holick MF. Vitamin D: importance in the prevention of cancers, type 1 diabetes, heart disease, and osteoporosis. Am J Clin Nutr. 2004;79:362–71.

    CAS  PubMed  Google Scholar 

  • Hollis BW. Assessment of vitamin D status and definition of normal circulating range of 25-hydroxyvitamin D. Curr Opin Endocrinol Diabetes Obes. 2008;15:489–94.

    Article  CAS  PubMed  Google Scholar 

  • Kuwabara A, Tsugawa N, Tanaka K, Uejima Y, Ogawa J, Otao N, Yamada N, Masaki T, Nishigori C, Moriwaki S, Okano T. High prevalence of vitamin D deficiency in patients with xeroderma pigmetosum-A under strict sun protection. Eur J Clin Nutr. 2015 Jun;69(6):693–6.

    Article  CAS  PubMed  Google Scholar 

  • Kannan S, Lim HW. Photoprotection and vitamin D: a review. Photodermatol Photoimmunol Photomed. 2014;30:137–45.

    Article  CAS  PubMed  Google Scholar 

  • Kimlin M, Harrison S, Nowak M, Moore M, Brodie A, Lang C. Does a high UV environment ensure adequate vitamin D status? J Photochem Photobiol B. 2007;89:139–47.

    Article  CAS  PubMed  Google Scholar 

  • Kligman EW, Watkins A, Johnson K, Kronland R. The impact of lifestyle factors on serum 25-hydroxy vitamin D levels in older adults: a preliminary study. Fam Pract Res J. 1989;9:11–9.

    CAS  PubMed  Google Scholar 

  • Lester E, Skinner RK, Wills MR. Season variation in serum- 25-hydroxyvitamin-D in the elderly in Britain. Lancet. 1977;7:979–80.

    Article  Google Scholar 

  • Liu PT, Stenger S, Li H, Wenzel L, Tan BH, Krutzik SR, et al. Toll-like receptor triggering of a vitamin D-mediated human antimicrobial response. Science. 2006;24(311):1770–3.

    Article  Google Scholar 

  • Looker AC, Pfeiffer CM, Lacher DA, Schleicher RL, Picciano MF, Yetley EA. Serum 25-hydroxyvitamin D status of the US population: 1988-1994 compared with 2000-2004. Am J Clin Nutr. 2008;88:1519–27.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • MacLaughlin JA, Anderson RR, Holick MF. Spectral character of sunlight modulates photosynthesis of previtamin D3 and its photoisomers in human skin. Science. 1982;216:1001–3.

    Article  CAS  PubMed  Google Scholar 

  • MacLaughlin J, Holick MF. Aging decreases the capacity of the skin to produce vitamin D3. J Clin Invest. 1985;76:1536–8.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • MacNeal RJ, Dinulos JG. Update on sun protection and tanning in children. Curr Opin Pediatr. 2007;19:425–9.

    Article  PubMed  Google Scholar 

  • Maia M, Maeda S, Marçon CR. Correlation between photoprotection and concentrations of 25-hydroxyvitamin D and parathyroid hormone. An Bras Dermatol. 2007;82(3):233–7.

    Article  Google Scholar 

  • Malabanan A, Veronikis IE, Holick MF. Redefining vitamin D insufficiency. Lancet. 1998;351:805–6.

    Article  CAS  PubMed  Google Scholar 

  • Malvy DJ, Guinot C, Preziosi P, Galan P, Chapuy MC, Maamer M, et al. Relationship between vitamin D status and skin phototype in general adult population. Photochem Photobiol. 2000;71:466–9.

    Article  CAS  PubMed  Google Scholar 

  • Marçon CR, Maia M. Vitamin D. In: Steiner D, Addor F, editors. Skin aging. 1st ed. Rio de Janeiro: AC Farmacêutica; 2014. p. 162–9.

    Google Scholar 

  • Matsuoka LY, Wortsman J, Dannenberg MJ, Hollis BW, Lu Z, Holick MF. Clothing prevents ultraviolet-B radiation- dependent photosynthesis of vitamin D3. J Clin Endocrinol Metab. 1992;75:1099–103.

    CAS  PubMed  Google Scholar 

  • Morison WL. Photoprotection by clothing. Dermatol Ther. 2003;16:16–22.

    Article  PubMed  Google Scholar 

  • Naylor MF, Boyd A, Smith DW, Cameron GS, Hubbard D, Neldner KH. High sun protection factor sunscreens in the suppression of actinic neoplasia. Arch Dermatol. 1995;131:170–5.

    Article  CAS  PubMed  Google Scholar 

  • O’Riordan JL. Rickets in the 17th century. J Bone Miner Res. 2006;21:1506–10.

    Article  PubMed  Google Scholar 

  • Parrish JA, Jaenicke KF, Anderson RR. Erythema and melanogenesis action spectra of normal human skin. Photochem Photobiol. 1982;36:187–91.

    Article  CAS  PubMed  Google Scholar 

  • Paterson CR, Moody JP, Pennington CR. Skin content of 7-dehydrocholesterol in patients with malabsorption. Nutrition. 1997;13:771–3.

    Article  CAS  PubMed  Google Scholar 

  • Perez-Castrillon JL, Vega G, Abad L, Sanz A, Chaves J, Hernandez G, et al. Effects of atorvastatin on vitamin D levels in patients with acute ischemic heart disease. Am J Cardiol. 2007;99:903–5.

    Article  CAS  PubMed  Google Scholar 

  • Reichrath J. The challenge resulting from positive and negative effects of sunlight: how much solar UV exposure is appropriate to balance between risks of vitamin D deficiency and skin cancer? Prog Biophys Mol Biol. 2006;92:9–16.

    Article  CAS  PubMed  Google Scholar 

  • Rejnmark L, Vestergaard P, Heickendorff L, Mosekilde L. Simvastatin does not affect vitamin D status, but low vitamin D levels are associated with dyslipidemia: results from a randomized, controlled trial. Int J Endocrinol. 2010;2010:957174.

    Article  PubMed  Google Scholar 

  • Ross AC, Manson JE, Abrams SA, Aloia JF, Brannon PM, Clinton SK, et al. The 2011 report on dietary reference intakes for calcium and vitamin D from the institute of medicine: what clinicians need to know. J Clin Endocrinol Metab. 2011;96(1):53–8.

    Article  CAS  PubMed  Google Scholar 

  • Salih FM. Effect of clothing varieties on solar photosynthesis of previtamin D3: an in vitro study. Photodermatol Photoimmunol Photomed. 2004;20:53–8.

    Article  CAS  PubMed  Google Scholar 

  • Sanguesa-Gómez C, Flores-Robles BJ, Andréu JL. Bone health, vitamin D and lupus. Reumatol Clin. 2015;11(4):232–6.

    Article  PubMed  Google Scholar 

  • Sayre RM, Huges SNG. Sun protective apparel: advancements in sun protection. Skin Cancer J. 1993;8:41–7.

    Google Scholar 

  • Sedrani SH, Elidrissy AW, El Arabi KM. Sunlight and vitamin D status in normal Saudi subjects. Am J Clin Nutr. 1983;38:129–32.

    CAS  PubMed  Google Scholar 

  • Shuster S, Black MM, McVitie E. The influence of age and sex on skin thickness, skin collagen and density. Br J Dermatol. 1975;93:639–43.

    Article  CAS  PubMed  Google Scholar 

  • Stender IM, Lock-Andersen J, Wulf HC. Sun-protection behavior and self-assessed burning tendency among sunbathers. Photodermatol Photoimmunol Photomed. 1996;12:162–5.

    Article  CAS  PubMed  Google Scholar 

  • Schalka S, Steiner D, Ravelli FN, Steiner T, Terena AC, Marçon CR, Ayres EL, Addor FA, Miot HA, Ponzio H, Duarte I, Neffá J, Cunha JA, Boza JC, Samorano Lde P, Corrêa Mde P, Maia M, Nasser N, Leite OM, Lopes OS, Oliveira PD, Meyer RL, Cestari T, Reis VM, Rego VR. Brazilian consensus on photoprotection. Brazilian Society of Dermatology. An Bras Dermatol. 2014;89(6 Suppl 1):1–74.

    Article  PubMed  PubMed Central  Google Scholar 

  • Silva AA. Improving photoprotection attitudes in the tropics: sunburn vs vitamin D. Photochem Photobiol. 2014;90(6):1446–54.

    Article  CAS  PubMed  Google Scholar 

  • Thieden E, Philipsen PA, Sandby-Møller J, Wulf HC. Sunscreen use related to UV exposure, age, sex, and occupation based on personal dosimeter readings and sun-exposure behavior diaries. Arch Dermatol. 2005;141:967–73.

    PubMed  Google Scholar 

  • Thieden E, Philipsen PA, Wulf HC. Ultraviolet radiation exposure pattern in winter compared with summer based on time-stamped personal dosimeter readings. Br J Dermatol. 2006;154:133–8.

    Article  CAS  PubMed  Google Scholar 

  • Thompson SC, Jolley D, Marks R. Reduction of solar keratoses by regular sunscreen use. N Engl J Med. 1993;329:1147–51.

    Article  CAS  PubMed  Google Scholar 

  • Vanchinathan V, Lim HW. A dermatologist’s perspective on vitamin D. Mayo Clin Proc. 2012;87(4):372–80.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Vieth R. Vitamin D supplementation, 25-hydroxyvitamin D concentrations, and safety. Am J Clin Nutr. 1999;69:842–56.

    CAS  PubMed  Google Scholar 

  • Walker SL, Hawk JLM, Young AR. Acute and chronic effects of ultraviolet radiation on the skin. In: Freedberg IM, Eisen AZ, Wolff K, Austen KF, Goldsmith LA, Katz SI, editors. Fitz-patrick’s dermatology in general medicine. 6th ed. New York: McGraw-Hill; 2003. p. 1275–82.

    Google Scholar 

  • Webb AR, De Costa BR, Holick MF. Sunlight regulates the cutaneous production of vitamin D3 by causing its photodegredation. J Clin Endocrinol Metab. 1989;68:882–7.

    Article  CAS  PubMed  Google Scholar 

  • Webb AR, Kline L, Holick MF. Influence of season and latitude on the cutaneous synthesis of vitamin D3: exposure to winter sunlight in Boston and Edmonton will not promote vitamin D3 synthesis in human skin. J Clin Endocrinol Metab. 1988;67:373–8.

    Article  CAS  PubMed  Google Scholar 

  • Webb AR, Pilbeam C, Hanafin N, Holick MF. An evaluation of the relative contributions of exposure to sunlight and of diet to the circulating concentrations of 25-hydroxyvitamin D in an elderly nursing home population in Boston. Am J Clin Nutr. 1990;51:1075–81.

    CAS  PubMed  Google Scholar 

  • Webb AR. Who, what, where and when-influences on cutaneous vitamin D synthesis. Prog Biophys Mol Biol. 2006;92:17–25.

    Article  CAS  PubMed  Google Scholar 

  • Weisman Y, Schen RJ, Eisenberg Z, Edelstein S, Harell A. Inadequate status and impaired metabolism of vitamin D in the elderly. Isr J Med Sci. 1981;17:19–21.

    CAS  PubMed  Google Scholar 

  • Wilkinson RJ, Llewelyn M, Toossi Z, Patel P, Pasvol G, Lalvani A, et al. Influence of vitamin D deficiency and vitamin D receptor polymorphisms on tuberculosis among Gujarati Asians in west London: a case-control study. Lancet. 2000;355:618–21.

    Article  CAS  PubMed  Google Scholar 

  • World Health Organization. Global solar UV index: a practical guide. Geneva: World Health Organization; 2002.

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Marcus Maia .

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2016 Springer International Publishing AG

About this entry

Cite this entry

Maia, M., Marçon, C. (2016). Vitamin D and Photoprotection. In: Issa, M., Tamura, B. (eds) Daily Routine in Cosmetic Dermatology. Clinical Approaches and Procedures in Cosmetic Dermatology. Springer, Cham. https://doi.org/10.1007/978-3-319-20250-1_12-1

Download citation

  • DOI: https://doi.org/10.1007/978-3-319-20250-1_12-1

  • Received:

  • Accepted:

  • Published:

  • Publisher Name: Springer, Cham

  • Online ISBN: 978-3-319-20250-1

  • eBook Packages: Springer Reference MedicineReference Module Medicine

Publish with us

Policies and ethics