Living Reference Work Entry

Daily Routine in Cosmetic Dermatology

Part of the series Clinical Approaches and Procedures in Cosmetic Dermatology pp 1-8

Date: Latest Version

Oral Photoprotection

  • Flávia Alvim Sant’Anna AddorAffiliated withMEDCIN Instituto da Pele Email author 
  • , Humberto PonzioAffiliated withFederal University of Rio Grande do Sul
  • , Flávia Naranjo RavelliAffiliated withComplexo Hospitalar ProMatre/Santa Joana


Better understanding of molecular damage caused by solar radiation has led to the growing study of molecules with antioxidant and anti-inflammatory activity against photodamage. Oral use of these substances is considered an important coadjutant in photoprotection strategy, due to two general mechanisms: prevention and mitigation of photodamage. Coming from nutrients, such as vitamins and functional foods, or herbal extracts, and, more recently, probiotics, molecules with oral photoprotection action have antioxidant action, protecting especially from damage to DNA and protein and lipid structures, but they can also prevent or mitigate UV-induced inflammation, acting on the epidermis and dermis. An increase in the minimal erythema dose has also been shown with some associations of nutrients.

Although the level of evidence varies considerably between the molecules studied and described, the most-used active constituents with proven safety and efficacy under systemic use are presented below.

These molecules act most often in association, providing a synergistic effect that also allows reduction of their respective concentrations and, consequently, greater tolerability for use.


Photoprotection Antioxidants Vitamins Photodermatosis Pycnogenol Polypodium leucotomos Ultraviolet