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Inorganic-Organic Hybrids for Biomedical Applications

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Handbook of Sol-Gel Science and Technology

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Abstract

Flexible sol-gel procedure is an excellent route to prepare inorganic-organic hybrids where homogenous precursor solutions yield solid or porous gels and composites in the size from macroscopic ranges (cm, mm) to microscopic (μm) and nanoscopic (nm) ranges. The present chapter first provides short introduction of inorganic-organic hybrids: historical aspects, constitution, and inorganic and organic components to be hybridized as well as their possible biomedical applications. Their biocompatibility is the most significant, and it is discussed in detail in terms of the fixation of various hybrid materials with hard and soft tissues. The primary topics are the behaviors of inorganic species like Si─OH, Ti─OH, calcium ions, and hydroxycarbonate apatite (HCA) deposition, as well as the roles of short peptides like arginine-glycine-aspartate (Arg-Gly-Asp; RGD) and mediating layers. Inorganic-organic layers with Ti─O or P─O favor anti-blood clotting (thrombosis) and polymer-apatite bonding in dentistry. Described are several biomedically applicable porous hybrids among a few silanes, natural polymers (gelatin, chitosan, collagen, and silk fibroin), and synthetic polymers poly(dimethylsilane), poly(lactic acid), and poly(caprolactone). Some are promising to repair damaged nerve systems. Electrospinning, bioprinting, and liquid phase deposition techniques are presented as versatile methods to fabricate fibrous membranes, 3-D architecture, and intermediating oxide layers. Hybrid nanoparticles are introduced as the promising drug delivery and therapeutic vehicles, such as cerasomes (ceramic + liposome), magnetoliposomes, nanomachines, or mesoporous silica. Finally, a few paragraphs stress the significance of quantum dots in the biomedical fields like biosensing or bioimaging.

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Authors and Affiliations

  1. Graduate School of Engineering, Kyushu Institute of Technology, 1-1 Sensui-cho, Tobata-ku, 804-8550, Kitakyushu, Japan

    Yuki Shirosaki

  2. Department of Applied Chemistry and Biotechnology, Okayama University, Tsushima, Okayama-shi, 700-8530, Japan

    Yuri Nakamura

  3. Graduate School of Natural Science and Technology, Okayama University, Tsushima, Okayama-shi, 700-8530, Japan

    Tomohiko Yoshioka

  4. Faculty of Engineering, Okayama University, Tsushima, Okayama-shi, 700-8530, Japan

    Akiyoshi Osaka

Authors
  1. Yuki Shirosaki
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  2. Yuri Nakamura
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  3. Tomohiko Yoshioka
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  4. Akiyoshi Osaka
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Corresponding author

Correspondence to Akiyoshi Osaka .

Editor information

Editors and Affiliations

  1. Rutgers University, Piscataway, New Jersey, USA

    Lisa Klein

  2. Madrid, Spain

    Mario Aparicio

  3. City University of New York, New York, USA

    Andrei Jitianu

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Shirosaki, Y., Nakamura, Y., Yoshioka, T., Osaka, A. (2016). Inorganic-Organic Hybrids for Biomedical Applications. In: Klein, L., Aparicio, M., Jitianu, A. (eds) Handbook of Sol-Gel Science and Technology. Springer, Cham. https://doi.org/10.1007/978-3-319-19454-7_76-1

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  • DOI: https://doi.org/10.1007/978-3-319-19454-7_76-1

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-19454-7

  • Online ISBN: 978-3-319-19454-7

  • eBook Packages: Springer Reference Chemistry and Mat. ScienceReference Module Physical and Materials ScienceReference Module Chemistry, Materials and Physics

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