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Monolithic Porous Silica for High Speed HPLC

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Handbook of Sol-Gel Science and Technology

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Abstract

As one of the successful applications of hierarchically porous monolithic silica, HPLC column without particle-packed structure is briefly introduced. With a progress of manufacturing technology over 20 years of development, highly efficient column structure can be fabricated in various column thickness; besides the traditional analytical column dimension of 4.6 mmID, semi-micro (1–2 mmID) and capillary (<0.5 mmID) formats are now available. Especially in the capillary format, elongated columns can separate very complex biochemical mixtures coupled with mass spectrometric detectors.

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Author information

Authors and Affiliations

  1. Department of Chemistry, Graduate School of Chemistry, Kyoto University, Sakyo-ku, Kyoto, 606-8502, Japan

    Kazuki Nakanishi

Authors
  1. Kazuki Nakanishi
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Correspondence to Kazuki Nakanishi .

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Editors and Affiliations

  1. Rutgers University, Piscataway, New Jersey, USA

    Lisa Klein

  2. Madrid, Spain

    Mario Aparicio

  3. City University of New York, New York, USA

    Andrei Jitianu

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Nakanishi, K. (2017). Monolithic Porous Silica for High Speed HPLC. In: Klein, L., Aparicio, M., Jitianu, A. (eds) Handbook of Sol-Gel Science and Technology. Springer, Cham. https://doi.org/10.1007/978-3-319-19454-7_54-1

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  • DOI: https://doi.org/10.1007/978-3-319-19454-7_54-1

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-19454-7

  • Online ISBN: 978-3-319-19454-7

  • eBook Packages: Springer Reference Chemistry and Mat. ScienceReference Module Physical and Materials ScienceReference Module Chemistry, Materials and Physics

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