Skip to main content
SpringerLink
Log in
Book cover

Handbook of Sol-Gel Science and Technology pp 1–29Cite as

Microparticles Preparation Using Water-in-Oil Emulsion

  • Living reference work entry
  • First Online:

  • 368 Accesses

Abstract

Various microparticles of ceramics and organic-inorganic composites can be fabricated through solgel reactions or aggregation of hydrogels in water-in-oil emulsions. Their particle size can be widely controlled from a submicron level to several dozens of micrometers. The particle size is predominantly governed by several preparation factors such as agitation speed, temperature of the emulsion, and hydrophilic-lipophilic balance and concentration of the surfactant. Not only single microparticles but also assembled cluster-like particles can be designed through encapsulation of colloidal silica in the emulsion. These microparticles are useful for biomedical applications such as drug carriers in drug delivery systems and intra-arterial treatment of deep-seated cancer by radiotherapy and hyperthermia. Furthermore, these microparticles can be imparted with a variety of functions, making them applicable in electrical applications and in the energy and environmental fields.

This is a preview of subscription content, log in via an institution.

References

  • Akartuna I, Studart AR, Tervoort E, Gonzenbach UT, Gauckler LJ. Stabilization of oil-in-water emulsions by colloidal particles modified with short amphiphiles. Langmuir. 2008;24:7161–8.

    Article  Google Scholar 

  • Aono H, Moritani K, Naohara T, Maehara T, Hirazawa H, Watanabe Y. New heat generation material in AC magnetic field for Y3Fe5O12-based powder material synthesized by reverse coprecipitation method. Mater Lett. 2011;65:1454–6.

    Article  Google Scholar 

  • Aono H, Senba R, Nishimori T, Naohara T. Preparation of Y3Fe5O12 microsphere using bead-milled nanosize powder for embolization therapy application. J Am Ceram Soc. 2013;96:3483–8.

    Article  Google Scholar 

  • Bush AJ, Beyer R, Trautman R, Barbé CJ, Bartlett JR. Ceramic micro-particles synthesised using emulsion and sol–gel technology: an investigation into the controlled release of encapsulants and the tailoring of micro-particle size. J Sol-Gel Sci Technol. 2004;32:85–90.

    Article  Google Scholar 

  • Cao SW, Zhu YJ, Ma MY, Li L, Zhang L. Hierarchically nanostructured magnetic hollow spheres of Fe3O4 and gamma-Fe2O3: preparation and potential application in drug delivery. J Phys Chem C. 2008;112:1851–6.

    Article  Google Scholar 

  • Chatterjee M, Naskar MK. Synthesis of yttrium–aluminum–garnet hollow microspheres by reverse-emulsion technique. J Am Ceram Soc. 2006;89:1443–6.

    Article  Google Scholar 

  • Cho YS, Yi GR, Kim SH, Pine DJ, Yang SM. Colloidal clusters of microspheres from water-in-oil emulsions. Chem Mater. 2005;17:5006–13.

    Article  Google Scholar 

  • Cushing BL, Kolesnichenko VL, O’Connor CJ. Recent advances in the liquid-phase syntheses of inorganic nanoparticles. Chem Rev. 2004;104:3893–946.

    Article  Google Scholar 

  • Davis HT. Factors determining emulsion type: hydrophile–lipophile balance and beyond. Colloids Surf A. 1994;91:9–24.

    Article  Google Scholar 

  • Deng YH, Wang CC, Hu JH, Yang WL, Fu SK. Investigation of formation of silica-coated magnetite nanoparticles via sol-gel approach. Colloids Surf A. 2005;262:87–93.

    Article  Google Scholar 

  • Erbe EM, Day DE. Chemical durability of Y2O3-Al2O3-SiO2 glasses for the in vivo delivery of beta radiation. J Biomed Mater Res. 1993;27:1301–8.

    Article  Google Scholar 

  • Esquena J, Pons R, Azemar N, Caelles J, Solans C. Preparation of monodisperse silica particles in emulsion media. Colloids Surf A. 1997;123–124:575–86.

    Article  Google Scholar 

  • Freymann G, Kitaev V, Lotsch BV, Ozin GA. Bottom-up assembly of photonic crystals. Chem Soc Rev. 2013;42:2528–54.

    Article  Google Scholar 

  • Griffin WC. Classification of surface-active agents by “HLB”. J Soc Cosmet Chem. 1949;1:311–26.

    Google Scholar 

  • Griffin WC. Calculation of HLB values of non-ionic surfactants. J Soc Cosmet Chem. 1954;5:249–56.

    Google Scholar 

  • Guo X, Hao G, Xie Y, Cai W, Yang H. Preparation of porous zirconia microspheres via emulsion method combined with phase separation. J Sol-Gel Sci Technol. 2015;76:651–7.

    Article  Google Scholar 

  • Hyatt MJ, Day DE. Glass properties of yttria-alumina-silica system. J Am Ceram Soc. 1987;70:283–7.

    Article  Google Scholar 

  • Jones SK, Winter JG. Experimental examination of a targeted hyperthermia system using inductively heated ferromagnetic microspheres in rabbit kidney. Phys Med Biol. 2001;46:385–98.

    Article  Google Scholar 

  • Kawashita M. Ceramic microspheres for biomedical applications. Int J Appl Ceram Technol. 2005;2:173–83.

    Article  Google Scholar 

  • Kawashita M, Toda S, Kim HM, Kokubo T, Masuda N. Preparation of antibacterial silver-doped silica glass microparticles. J Biomed Mater Res. 2003a;66A:266–74.

    Article  Google Scholar 

  • Kawashita M, Shineha R, Kim HM, Kokubo T, Inoue Y, Araki N, Nagata Y, Hiraoka M, Sawada Y. Preparation of ceramic microparticles for in situ radiotherapy of deep-seated cancer. Biomaterials. 2003b;24:2955–63.

    Article  Google Scholar 

  • Kawashita M, Tanaka M, Kokubo T, Inoue Y, Yao T, Hamada S, Shinjo T. Preparation of ferrimagnetic magnetite microparticles for in situ hyperthermic treatment of cancer. Biomaterials. 2005;26:2231–8.

    Article  Google Scholar 

  • Kawashita M, Tanaka Y, Ueno S, Liu G, Li Z, Miyazaki T. In vitro apatite formation and drug loading/release of porous TiO2 microparticles prepared by sol-gel processing with different SiO2 nanoparticle contents. Mater Sci Eng C. 2015;50:317–23.

    Article  Google Scholar 

  • Kim DH, Lee YK, Kim KM, Kim KN, Choi SY, Shim IB. Synthesis of Ba-ferrite microspheres doped with Sr for thermoseeds in hyperthermia. J Mater Sci. 2004;39:6847–50.

    Article  Google Scholar 

  • Kokubo T, Takadama H. How useful is SBF in predicting in vivo bone bioactivity? Biomaterials. 2006;27:2907–15.

    Article  Google Scholar 

  • Kong L, Zhang C, Wang J, Qiao W, Ling L, Long D. Nanoarchitectured Nb2O5 hollow, Nb2O5@carbon and NbO2@ carbon core-shell microspheres for ultrahigh-rate intercalation pseudocapacitors. Sci Rep. 2016;6:21177.

    Article  Google Scholar 

  • Laurent S, Forge D, Port M, Roch A, Robic C, Elst LV, Muller RN. Magnetic iron oxide nanoparticles: synthesis, stabilization, vectorization, physicochemical characterizations, and biological applications. Chem Rev. 2008;108:2064–110.

    Article  Google Scholar 

  • Lavy D, Zayat M. The sol-gel handbook, volume 1: synthesis and processing. Weinheim: Wiley-VCH; 2015.

    Book  Google Scholar 

  • Lawrence MJ, Rees GD. Microemulsion-based media as novel drug delivery systems. Adv Drug Deliv Rev. 2000;45:89–121.

    Article  Google Scholar 

  • Lee MH, Tai CY, Lu CH. Synthesis of spherical zirconia by precipitation between two water/oil emulsions. J Eur Ceram Soc. 1999;19:2593–603.

    Article  Google Scholar 

  • Li W, Sha X, Dong W, Wang Z. Synthesis of stable hollow silica microparticles with mesoporous shell in nonionic W/O emulsion. Chem Commun. 2002;20:2434–5.

    Article  Google Scholar 

  • Li DY, Guan ZC, Zhang WH, Zhou X, Zhang WY, Zhuang ZX, Wang XR, Yang CJ. Synthesis of uniform-size hollow silica microspheres through interfacial polymerization in monodisperse water-in-oil droplets. ACS Appl Mater Interfaces. 2010a;2:2711–4.

    Article  Google Scholar 

  • Li Z, Kawashita M, Araki N, Mitsumori M, Hiraoka M, Doi M. Magnetite nanoparticles with high heating efficiency for application in hyperthermia of cancer. Mater Sci Eng C. 2010b;30:990–6.

    Article  Google Scholar 

  • Li Z, Kawashita M, Araki N, Mitsumori M, Hiraoka M, Doi M. Magnetic SiO2 gel microparticles for arterial embolization hyperthermia. Biomed Mater. 2010c;5:065010.

    Article  Google Scholar 

  • Li Z, Kawashita M, Doi M. Sol-gel synthesis and characterization of magnetic TiO2 microparticles. J Ceram Soc Jpn. 2010d;118:467–73.

    Article  Google Scholar 

  • Li Z, Kawashita M, Kudo T, Kanetaka H. Sol-gel synthesis, characterization and in vitro compatibility evaluation of iron nanoparticle encapsulating-silica microparticles for hyperthermia of cancer. J Mater Sci Mater Med. 2012;23:2461–9.

    Article  Google Scholar 

  • Li Z, Miyazaki T, Kawashita M. Preparation and in vitro apatite-forming ability of porous and non-porous titania microparticles. J Ceram Soc Jpn. 2013;121:782–7.

    Article  Google Scholar 

  • Lin S, Shi L, Yoshida H, Li M, Zou X. Synthesis of hollow spherical tantalum oxide nanoparticles and their photocatalytic activity for hydrogen production. J Solid State Chem. 2013;199:15–20.

    Article  Google Scholar 

  • Liu JG, Wilcox DL. Factors influencing the formation of hollow ceramic microspheres by water extraction of colloidal droplet. J Mater Res. 1995;10:84–94.

    Article  Google Scholar 

  • Liu G, Kawashita M, Li Z, Miyazaki T, Kanetaka H. Sol-gel synthesis of magnetic TiO2 microparticles and characterization of their in vitro heating ability for hyperthermia treatment of cancer. J Sol-Gel Sci Technol. 2015;5:90–7.

    Article  Google Scholar 

  • Livage J, Henry M, Sanchez C. Sol-gel chemistry of transition metal oxides. Prog Solid State Chem. 1988;18:250–341.

    Article  Google Scholar 

  • Masuda N, Kawashita M, Kokubo T. Antibacterial activity of silver-doped silica glass microparticles prepared by a sol-gel method. J Biomed Mater Res B Appl Biomater. 2007;83B:114–20.

    Article  Google Scholar 

  • Minamimura T, Sato H, Kasaoka S, Saito T, Ishizawa S, Takemori S, Tazawa K, Tsukada K. Tumor regression by inductive hyperthermia combined with hepatic embolization using dextran magnetite-incorporated microspheres in rats. Int J Oncol. 2000;16:1153–8.

    Google Scholar 

  • Miyazaki T, Kai T, Ishida E, Kawashita M, Hiraoka M. Fabrication of yttria microcapsules for radiotherapy from water/oil emulsion. J Ceram Soc Jpn. 2010;118:479–82.

    Article  Google Scholar 

  • Miyazaki T, Miyaoka A, Ishida E, Li Z, Kawashita M, Hiraoka M. Preparation of ferromagnetic microcapsules for hyperthermia using water/oil emulsion as a reaction field. Mater Sci Eng C. 2012;32:692–6.

    Article  Google Scholar 

  • Miyazaki T, Anan S, Ishida E, Kawashita M. Carboxymethyldextran/magnetite hybrid microparticles designed for hyperthermia. J Mater Sci Mater Med. 2013;24:1125–9.

    Article  Google Scholar 

  • Miyazaki T, Inoue T, Shirosaki Y, Kawashita M, Matsubara T, Matsumine A. Bisphosphonate release profiles from magnetite microspheres. J Biomater Appl. 2014a;29:543–7.

    Article  Google Scholar 

  • Miyazaki T, Suda T, Shirosaki Y, Kawashita M. Fabrication of yttrium phosphate microcapsules by an emulsion route for in situ cancer radiotherapy. J Med Biol Eng. 2014b;34:14–7.

    Article  Google Scholar 

  • Miyazaki T, Tanaka T, Shirosaki Y, Kawashita M. Yttrium phosphate microparticles with enriched phosphorus content prepared for radiotherapy of deep-seated cancer. Ceram Int. 2014c;40:15259–63.

    Article  Google Scholar 

  • Morel AL, Nikitenko SI, Gionnet K, Wattiaux A, Lai-Kee-Him J, Labrugere C, Chevalier B, Deleris G, Petibois C, Brisson A, Simonoff M. Sonochemical approach to the synthesis of Fe3O4@SiO2 core-shell nanoparticles with tunable properties. ACS Nano. 2008;5:847–56.

    Article  Google Scholar 

  • Ogihara T, Ikemoto T, Mizutani N, Kato M, Mitarai Y. Formation of monodispersed Ta2O5 powders. J Mater Sci. 1986;21:2771–4.

    Article  Google Scholar 

  • Richardson K, Aknic M. Preparation of spherical yttrium oxide powders using emulsion evaporation. Ceram Int. 1987;13:253–61.

    Article  Google Scholar 

  • Richardson K, Aknic M. Sintering of yttrium oxide powders prepared by emulsion evaporation. Ceram Int. 1988;14:101–8.

    Article  Google Scholar 

  • Salem R, Lewandowski R, Roberts C, Goin J, Thurston K, Abouljoud M, Courtney A. Use of yttrium-90 glass microspheres (TheraSphere) for the treatment of unresectable hepatocellular carcinoma in patients with portal vein thrombosis. J Vasc Interv Radiol. 2004;15:335–45.

    Article  Google Scholar 

  • Siladitya B, Chatterjee M, Ganguli D. Role of a surface active agent in the sol-emulsion-gel synthesis of spherical alumina powders. J Sol-Gel Sci Technol. 1999;15:271–7.

    Article  Google Scholar 

  • Singh RK, Garg A, Bandyopadhyaya R, Mishra BK. Density fractionated hollow silica microspheres with high-yield by non-polymeric sol–gel/emulsion route. Colloids Surf A. 2007;310:39–45.

    Article  Google Scholar 

  • Stöber W, Fink A, Bohn E. Controlled growth of monodisperse silica spheres in the micron size range. J Colloid Interface Sci. 1968;26:62–79.

    Article  Google Scholar 

  • Tago T, Hatsuta T, Miyajima K, Kishida M, Tashiro S, Wakabayashi K. Novel synthesis of silica-coated ferrite nanoparticles prepared using water-in-oil microemulsion. J Am Ceram Soc. 2002;85:2188–94.

    Article  Google Scholar 

  • Tani T, Watanabe N, Takatori K, Pratsinis SE. Morphology of oxide particles made by the emulsion combustion method. J Am Ceram Soc. 2003;86:898–904.

    Article  Google Scholar 

  • Viroonchatapan E, Ueno M, Sato H, Adachi I, Nagae H, Tazawa K, Horikoshi I. Preparation and characterization of dextran magnetite-incorporated thermosensitive liposomes: an on-line flow system for quantifying magnetic responsiveness. Pharm Res. 1995;12:1176–83.

    Article  Google Scholar 

  • Wei W, Ma GH, Hu G, Yu D, Mcleish T, Su ZG, Shen ZY. Preparation of hierarchical hollow CaCO3 particles and the application as anticancer drug carrier. J Am Chem Soc. 2008;130:15808–10.

    Article  Google Scholar 

  • Xu J, Yang HB, Fu WY, Du K, Sui YM, Chen JJ, Zeng Y, Li MH, Zou G. Preparation and magnetic properties of magnetite nanoparticles by sol-gel method. J Magn Magn Mater. 2007;309:307–11.

    Article  Google Scholar 

  • Yamashita H, Demiya M, Mori H, Maekawa T. Synthesis of microporous silica-gel particles in W/O emulsion and an application to high-performance liquid chromatography. J Ceram Soc Jpn. 1992;100:1444–7. (in Japanese).

    Article  Google Scholar 

  • Yamashita H, Nozaki K, Toshinari K, Mima T, Maekawa T. Synthesis of spherical porous zirconia and titania particles in W/O emulsion. J Ceram Soc Jpn. 1998;106:1184–9. (in Japanese).

    Article  Google Scholar 

  • Yamashita H, Ogawa Y, Maekawa T. Preparation of porous titania spheres by sol-gel method in water-in-oil emulsion. Bunseki Kagaku. 2007;56:511–4. (in Japanese).

    Article  Google Scholar 

  • Yang H, Xie Y, Hao G, Cai W, Guo X. Preparation of porous alumina microspheres via an oil-in-water emulsion method accompanied by a sol–gel process. New J Chem. 2016;40:589–95.

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Graduate School of Biomedical Engineering, Tohoku University, Aramaki-Aoba, Aoba-ku, 980-8579, Sendai, Japan

    Masakazu Kawashita

  2. Graduate School of Life Science and Systems Engineering, Kyushu Institute of Technology, 2-4 Hibikino, Wakamatsu-ku, 808-0196, Kitakyushu-shi, Fukuoka, Japan

    Toshiki Miyazaki

Authors
  1. Masakazu Kawashita
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Toshiki Miyazaki
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Masakazu Kawashita .

Editor information

Editors and Affiliations

  1. Rutgers University, Piscataway, New Jersey, USA

    Lisa Klein

  2. Madrid, Spain

    Mario Aparicio

  3. City University of New York, New York, USA

    Andrei Jitianu

Rights and permissions

Reprints and permissions

Copyright information

© 2016 Springer International Publishing AG

About this entry

Cite this entry

Kawashita, M., Miyazaki, T. (2016). Microparticles Preparation Using Water-in-Oil Emulsion. In: Klein, L., Aparicio, M., Jitianu, A. (eds) Handbook of Sol-Gel Science and Technology. Springer, Cham. https://doi.org/10.1007/978-3-319-19454-7_128-1

Download citation

  • DOI: https://doi.org/10.1007/978-3-319-19454-7_128-1

  • Received:

  • Accepted:

  • Published:

  • Publisher Name: Springer, Cham

  • Online ISBN: 978-3-319-19454-7

  • eBook Packages: Springer Reference Chemistry and Mat. ScienceReference Module Physical and Materials ScienceReference Module Chemistry, Materials and Physics

Publish with us

Policies and ethics

Search

Navigation