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Oral Manifestations of Diabetes

  • David DeanEmail author
  • Beatrice Gandara
Reference work entry

Abstract

The classic pathophysiologic features of diabetes mellitus (DM), including immune dysregulation, vasculopathy, and neuropathy, predispose diabetic individuals to numerous oral complications. Individuals with diabetes are at increased risk for periodontal disease, salivary gland dysfunction, dental caries, mucosal abnormalities, and oral burning, all of which can negatively impact patient quality of life. The bidirectional relationship between diabetes and periodontal disease is of particular importance due to the negative effect of periodontitis on glycemic control and the potential benefit of periodontal therapy on glycemic control. Emerging evidence has also identified decreased healthcare costs in diabetic individuals receiving regular periodontal therapy. Unfortunately, despite the numerous oral manifestations of diabetes and their potential impact on systemic health, many diabetic individuals are not fully aware of the relationship between their diabetes and oral health. Close collaboration between the medical and dental team can positively benefit the diabetic population through early diagnosis and management of the oral complications of diabetes.

Keywords

Diabetes Periodontitis Hyperglycemia Diabetes complications Candidiasis Dental caries Stomatitis Salivary dysfunction 

References

  1. 1.
    Löe H. Periodontal disease. The sixth complication of diabetes mellitus. Diabetes Care. 1993;16(1):329–34.PubMedCrossRefGoogle Scholar
  2. 2.
    Klokkevold P, Mealey B. Influence of systemic conditions. In: Newman M, Takei H, Klokkevold P, Carranza F, editors. Carranza’s clinical periodontology. St. Louis: Elsevier Saunders; 2015.Google Scholar
  3. 3.
    Newman MG, Takei HH, Klokkevold PR, Carranza FA. Carranza’s clinical periodontology. St. Louis: Elsevier Saunders; 2015.Google Scholar
  4. 4.
    Fiorellini J, Stathopoulou P. Clinical features of gingivitis. In: Newman M, Takei H, Klokkevold P, Carranza F, editors. Carranza’s clinical periodontology. St. Louis: Elsevier Saunders; 2015.Google Scholar
  5. 5.
    Ervasti T, Knuuttila M, Pohjamo L, Haukipuro K. Relation between control of diabetes and gingival bleeding. J Periodontol. 1985;56(3):154–7.PubMedCrossRefGoogle Scholar
  6. 6.
    de Pommereau V, Dargent-Paré C, Robert JJ, Brion M. Periodontal status in insulin-dependent diabetic adolescents. J Clin Periodontol. 1992;19(9 Pt 1):628–32.PubMedCrossRefGoogle Scholar
  7. 7.
    Cutler CW, Machen RL, Jotwani R, Iacopino AM. Heightened gingival inflammation and attachment loss in type 2 diabetics with hyperlipidemia. J Periodontol. 1999;70(11):1313–21.PubMedCrossRefGoogle Scholar
  8. 8.
    Cianciola LJ, Park BH, Bruck E, Mosovich L, Genco RJ. Prevalence of periodontal disease in insulin-dependent diabetes mellitus (juvenile diabetes). J Am Dent Assoc. 1982;104(5):653–60.PubMedCrossRefGoogle Scholar
  9. 9.
    Seppälä B, Seppälä M, Ainamo J. A longitudinal study on insulin-dependent diabetes mellitus and periodontal disease. J Clin Periodontol. 1993;20(3):161–5.PubMedCrossRefGoogle Scholar
  10. 10.
    Salvi GE, Kandylaki M, Troendle A, Persson GR, Lang NP. Experimental gingivitis in type 1 diabetics: a controlled clinical and microbiological study. J Clin Periodontol. 2005;32(3):310–6.PubMedCrossRefGoogle Scholar
  11. 11.
    Karjalainen KM, Knuuttila ML. The onset of diabetes and poor metabolic control increases gingival bleeding in children and adolescents with insulin-dependent diabetes mellitus. J Clin Periodontol. 1996;23(12):1060–7.PubMedCrossRefGoogle Scholar
  12. 12.
    NIDCR Data and Statistics: Periodontal (Gum) Disease: National Institute of Dental and Craniofacial Research; [updated May 28, 2014]. Available from: http://www.nidcr.nih.gov/DataStatistics/FindDataByTopic/GumDisease/
  13. 13.
    Carranza F, Camargo P, Takei H. Bone loss and patterns of bone destruction. In: Newman M, Takei H, Klokkevold P, Carranza F, editors. Carranza’s clinical periodontology. St. Louis: Elsevier Saunders; 2015.Google Scholar
  14. 14.
    American Academy of Periodontology. Position paper: epidemiology of periodontal diseases. J Periodontol. 1996;67(9):935–45.Google Scholar
  15. 15.
    Ismail AI, Burt BA, Eklund SA. Epidemiologic patterns of smoking and periodontal disease in the United States. J Am Dent Assoc. 1983;106(5):617–21.PubMedCrossRefGoogle Scholar
  16. 16.
    Burt B. Research SiaTCotAAoP. Position paper: epidemiology of periodontal diseases. J Periodontol. 2005;76(8):1406–19.PubMedCrossRefGoogle Scholar
  17. 17.
    Novak K, Novak MJ. Clinical risk assessment. In: Newman M, Takei H, Klokkevold P, Carranza F, editors. Carranza’s clinical periodontology. St. Louis: Elsevier Saunders; 2015.Google Scholar
  18. 18.
    Persson GR. Diabetes and periodontal disease: an update for HealthCare Providers. Diabetes Spectrum. 2011;24(4):195–8.CrossRefGoogle Scholar
  19. 19.
    Eke PI, Dye BA, Wei L, Thornton-Evans GO, Genco RJ, CDC Periodontal Disease Surveillance workgroup: James Beck (University of North Carolina CH, U. S. A.), Gordon Douglass (Past President, American Academy of Periodontology), R.y Page (University of Washin). Prevalence of periodontitis in adults in the United States: 2009 and 2010. J Dent Res. 2012;91(10):914–20.Google Scholar
  20. 20.
    Eke PI, Dye BA, Wei L, Slade GD, Thornton-Evans GO, Borgnakke WS, et al. Update on prevalence of periodontitis in adults in the United States: NHANES 2009 to 2012. J Periodontol. 2015;86(5):611–22.PubMedPubMedCentralCrossRefGoogle Scholar
  21. 21.
    Papapanou PN. Periodontal diseases: epidemiology. Ann Periodontol. 1996;1(1):1–36.PubMedCrossRefGoogle Scholar
  22. 22.
    Mealey BL, Oates TW, Periodontology AAo. Diabetes mellitus and periodontal diseases. J Periodontol. 2006;77(8):1289–303.PubMedCrossRefGoogle Scholar
  23. 23.
    Mealey BL, Rose LF. Diabetes mellitus and inflammatory periodontal diseases. Curr Opin Endocrinol Diabetes Obes. 2008;15(2):135–41.PubMedCrossRefGoogle Scholar
  24. 24.
    Lakschevitz F, Aboodi G, Tenenbaum H, Glogauer M. Diabetes and periodontal diseases: interplay and links. Curr Diabetes Rev. 2011;7(6):433–9.PubMedCrossRefGoogle Scholar
  25. 25.
    Chee B, Park B, Bartold PM. Periodontitis and type II diabetes: a two-way relationship. Int J Evid Based Healthc. 2013;11(4):317–29.PubMedCrossRefGoogle Scholar
  26. 26.
    Borgnakke WS, Ylöstalo PV, Taylor GW, Genco RJ. Effect of periodontal disease on diabetes: systematic review of epidemiologic observational evidence. J Periodontol. 2013;84 Suppl 4:S135–52.PubMedGoogle Scholar
  27. 27.
    Taylor GW. Bidirectional interrelationships between diabetes and periodontal diseases: an epidemiologic perspective. Ann Periodontol. 2001;6(1):99–112.PubMedCrossRefGoogle Scholar
  28. 28.
    Chávarry NG, Vettore MV, Sansone C, Sheiham A. The relationship between diabetes mellitus and destructive periodontal disease: a meta-analysis. Oral Health Prev Dent. 2009;7(2):107–27.PubMedGoogle Scholar
  29. 29.
    Khader YS, Dauod AS, El-Qaderi SS, Alkafajei A, Batayha WQ. Periodontal status of diabetics compared with nondiabetics: a meta-analysis. J Diabetes Complications. 2006;20(1):59–68.PubMedCrossRefGoogle Scholar
  30. 30.
    Lalla E, Papapanou PN. Diabetes mellitus and periodontitis: a tale of two common interrelated diseases. Nat Rev Endocrinol. 2011;7(12):738–48.PubMedCrossRefGoogle Scholar
  31. 31.
    Chapple IL, Genco R, workshop wgotjEA. Diabetes and periodontal diseases: consensus report of the Joint EFP/AAP Workshop on Periodontitis and Systemic Diseases. J Periodontol. 2013;84 Suppl 4:S106–12.PubMedGoogle Scholar
  32. 32.
    Taylor JJ, Preshaw PM, Lalla E. A review of the evidence for pathogenic mechanisms that may link periodontitis and diabetes. J Periodontol. 2013;84 Suppl 4:S113–34.PubMedGoogle Scholar
  33. 33.
    Taylor GW, Burt BA, Becker MP, Genco RJ, Shlossman M, Knowler WC, et al. Severe periodontitis and risk for poor glycemic control in patients with non-insulin-dependent diabetes mellitus. J Periodontol. 1996;67 Suppl 10:1085–93.PubMedCrossRefGoogle Scholar
  34. 34.
    Demmer RT, Jacobs DR, Singh R, Zuk A, Rosenbaum M, Papapanou PN, et al. Periodontal bacteria and prediabetes prevalence in ORIGINS: the oral infections, glucose intolerance, and insulin resistance study. J Dent Res. 2015;94 Suppl 9:201S–11.PubMedPubMedCentralCrossRefGoogle Scholar
  35. 35.
    Taylor GW, Burt BA, Becker MP, Genco RJ, Shlossman M, Knowler WC, et al. Non-insulin dependent diabetes mellitus and alveolar bone loss progression over 2 years. J Periodontol. 1998;69(1):76–83.PubMedCrossRefGoogle Scholar
  36. 36.
    Tervonen T, Karjalainen K, Knuuttila M, Huumonen S. Alveolar bone loss in type 1 diabetic subjects. J Clin Periodontol. 2000;27(8):567–71.PubMedCrossRefGoogle Scholar
  37. 37.
    Lalla E, Park DB, Papapanou PN, Lamster IB. Oral disease burden in northern Manhattan patients with diabetes mellitus. Am J Public Health. 2008;98 Suppl 9:S91–4.PubMedPubMedCentralCrossRefGoogle Scholar
  38. 38.
    Wu YY, Xiao E, Graves DT. Diabetes mellitus related bone metabolism and periodontal disease. Int J Oral Sci. 2015;7(2):63–72.PubMedPubMedCentralCrossRefGoogle Scholar
  39. 39.
    Tsai C, Hayes C, Taylor GW. Glycemic control of type 2 diabetes and severe periodontal disease in the US adult population. Community Dent Oral Epidemiol. 2002;30(3):182–92.PubMedCrossRefGoogle Scholar
  40. 40.
    Kaur G, Holtfreter B, Rathmann W, Rathmann WG, Schwahn C, Wallaschofski H, et al. Association between type 1 and type 2 diabetes with periodontal disease and tooth loss. J Clin Periodontol. 2009;36(9):765–74.PubMedCrossRefGoogle Scholar
  41. 41.
    Bagdade JD, Root RK, Bulger RJ. Impaired leukocyte function in patients with poorly controlled diabetes. Diabetes. 1974;23(1):9–15.PubMedCrossRefGoogle Scholar
  42. 42.
    Molenaar DM, Palumbo PJ, Wilson WR, Ritts RE. Leukocyte chemotaxis in diabetic patients and their nondiabetic first-degree relatives. Diabetes. 1976;25 Suppl 2:880–3.PubMedGoogle Scholar
  43. 43.
    Bagdade JD, Stewart M, Walters E. Impaired granulocyte adherence. A reversible defect in host defense in patients with poorly controlled diabetes. Diabetes. 1978;27(6):677–81.PubMedCrossRefGoogle Scholar
  44. 44.
    Bagdade JD, Walters E. Impaired granulocyte adherence in mildly diabetic patients: effects of tolazamide treatment. Diabetes. 1980;29(4):309–11.PubMedCrossRefGoogle Scholar
  45. 45.
    Manouchehr-Pour M, Spagnuolo PJ, Rodman HM, Bissada NF. Comparison of neutrophil chemotactic response in diabetic patients with mild and severe periodontal disease. J Periodontol. 1981;52(8):410–5.PubMedCrossRefGoogle Scholar
  46. 46.
    McMullen JA, Van Dyke TE, Horoszewicz HU, Genco RJ. Neutrophil chemotaxis in individuals with advanced periodontal disease and a genetic predisposition to diabetes mellitus. J Periodontol. 1981;52(4):167–73.PubMedCrossRefGoogle Scholar
  47. 47.
    Shetty N, Thomas B, Ramesh A. Comparison of neutrophil functions in diabetic and healthy subjects with chronic generalized periodontitis. J Indian Soc Periodontol. 2008;12(2):41–4.PubMedPubMedCentralCrossRefGoogle Scholar
  48. 48.
    Mowat A, Baum J. Chemotaxis of polymorphonuclear leukocytes from patients with diabetes mellitus. N Engl J Med. 1971;284(12):621–7.PubMedCrossRefGoogle Scholar
  49. 49.
    Alba-Loureiro TC, Munhoz CD, Martins JO, Cerchiaro GA, Scavone C, Curi R, et al. Neutrophil function and metabolism in individuals with diabetes mellitus. Braz J Med Biol Res. 2007;40(8):1037–44.PubMedCrossRefGoogle Scholar
  50. 50.
    Naghibi M, Smith RP, Baltch AL, Gates SA, Wu DH, Hammer MC, et al. The effect of diabetes mellitus on chemotactic and bactericidal activity of human polymorphonuclear leukocytes. Diabetes Res Clin Pract. 1987;4(1):27–35.PubMedCrossRefGoogle Scholar
  51. 51.
    Wong SL, Demers M, Martinod K, Gallant M, Wang Y, Goldfine AB, et al. Diabetes primes neutrophils to undergo NETosis, which impairs wound healing. Nat Med. 2015;21(7):815–9.PubMedPubMedCentralCrossRefGoogle Scholar
  52. 52.
    Graves DT, Liu R, Oates TW. Diabetes-enhanced inflammation and apoptosis: impact on periodontal pathosis. Periodontol 2000. 2007;45:128–37.PubMedCrossRefGoogle Scholar
  53. 53.
    Pacios S, Kang J, Galicia J, Gluck K, Patel H, Ovaydi-Mandel A, et al. Diabetes aggravates periodontitis by limiting repair through enhanced inflammation. FASEB J. 2012;26(4):1423–30.PubMedPubMedCentralCrossRefGoogle Scholar
  54. 54.
    Preshaw P. Periodontal pathogenesis. In: Newman M, Takei H, Klokkevold P, Carranza F, editors. Carranza’s clinical periodontology. St. Louis: Elsevier Saunders; 2015.Google Scholar
  55. 55.
    Delamaire M, Maugendre D, Moreno M, Le Goff MC, Allannic H, Genetet B. Impaired leucocyte functions in diabetic patients. Diabet Med. 1997;14(1):29–34.PubMedCrossRefGoogle Scholar
  56. 56.
    Golub LM, Nicoll GA, Iacono VJ, Ramamurthy NS. In vivo crevicular leukocyte response to a chemotactic challenge: inhibition by experimental diabetes. Infect Immun. 1982;37(3):1013–20.PubMedPubMedCentralGoogle Scholar
  57. 57.
    Lalla E, Lamster IB, Feit M, Huang L, Spessot A, Qu W, et al. Blockade of RAGE suppresses periodontitis-associated bone loss in diabetic mice. J Clin Invest. 2000;105(8):1117–24.PubMedPubMedCentralCrossRefGoogle Scholar
  58. 58.
    Pacios S, Andriankaja O, Kang J, Alnammary M, Bae J, de Brito Bezerra B, et al. Bacterial infection increases periodontal bone loss in diabetic rats through enhanced apoptosis. Am J Pathol. 2013;183(6):1928–35.PubMedCrossRefGoogle Scholar
  59. 59.
    Gyurko R, Siqueira CC, Caldon N, Gao L, Kantarci A, Van Dyke TE. Chronic hyperglycemia predisposes to exaggerated inflammatory response and leukocyte dysfunction in Akita mice. J Immunol. 2006;177(10):7250–6.PubMedPubMedCentralCrossRefGoogle Scholar
  60. 60.
    Silva JA, Lopes Ferrucci D, Peroni LA, de Paula IE, Rossa-Junior C, Carvalho HF, et al. Periodontal disease-associated compensatory expression of osteoprotegerin is lost in type 1 diabetes mellitus and correlates with alveolar bone destruction by regulating osteoclastogenesis. Cells Tissues Organs. 2012;196(2):137–50.PubMedCrossRefGoogle Scholar
  61. 61.
    Liu R, Bal HS, Desta T, Krothapalli N, Alyassi M, Luan Q, et al. Diabetes enhances periodontal bone loss through enhanced resorption and diminished bone formation. J Dent Res. 2006;85(6):510–4.PubMedPubMedCentralCrossRefGoogle Scholar
  62. 62.
    Kang J, de Brito Bezerra B, Pacios S, Andriankaja O, Li Y, Tsiagbe V, et al. Aggregatibacter actinomycetemcomitans infection enhances apoptosis in vivo through a caspase-3-dependent mechanism in experimental periodontitis. Infect Immun. 2012;80(6):2247–56.PubMedPubMedCentralCrossRefGoogle Scholar
  63. 63.
    Taylor G, Graves D, Lamster I. Periodontal disease as a complication of diabetes mellitus. In: Lamster I, editor. Diabetes mellitus and oral health: an interprofessional approach. Ames: Wiley Blackwell; 2014. p. 130–1.Google Scholar
  64. 64.
    Murillo J, Wang Y, Xu X, Klebe RJ, Chen Z, Zardeneta G, et al. Advanced glycation of type I collagen and fibronectin modifies periodontal cell behavior. J Periodontol. 2008;79(11):2190–9.PubMedPubMedCentralCrossRefGoogle Scholar
  65. 65.
    Ren L, Fu Y, Deng Y, Qi L, Jin L. Advanced glycation end products inhibit the expression of collagens type I and III by human gingival fibroblasts. J Periodontol. 2009;80(7):1166–73.PubMedCrossRefGoogle Scholar
  66. 66.
    Alikhani M, Alikhani Z, Graves DT. FOXO1 functions as a master switch that regulates gene expression necessary for tumor necrosis factor-induced fibroblast apoptosis. J Biol Chem. 2005;280(13):12096–102.PubMedCrossRefGoogle Scholar
  67. 67.
    Zambon JJ, Reynolds H, Fisher JG, Shlossman M, Dunford R, Genco RJ. Microbiological and immunological studies of adult periodontitis in patients with noninsulin-dependent diabetes mellitus. J Periodontol. 1988;59(1):23–31.PubMedCrossRefGoogle Scholar
  68. 68.
    Sbordone L, Ramaglia L, Barone A, Ciaglia RN, Iacono VJ. Periodontal status and subgingival microbiota of insulin-dependent juvenile diabetics: a 3-year longitudinal study. J Periodontol. 1998;69(2):120–8.PubMedCrossRefGoogle Scholar
  69. 69.
    Casarin RC, Barbagallo A, Meulman T, Santos VR, Sallum EA, Nociti FH, et al. Subgingival biodiversity in subjects with uncontrolled type-2 diabetes and chronic periodontitis. J Periodontal Res. 2013;48(1):30–6.PubMedCrossRefGoogle Scholar
  70. 70.
    Ebersole JL, Holt SC, Hansard R, Novak MJ. Microbiologic and immunologic characteristics of periodontal disease in Hispanic americans with type 2 diabetes. J Periodontol. 2008;79(4):637–46.PubMedCrossRefGoogle Scholar
  71. 71.
    Demmer RT, Desvarieux M, Holtfreter B, Jacobs DR, Wallaschofski H, Nauck M, et al. Periodontal status and A1C change: longitudinal results from the study of health in Pomerania (SHIP). Diabetes Care. 2010;33(5):1037–43.PubMedPubMedCentralCrossRefGoogle Scholar
  72. 72.
    Janket SJ, Wightman A, Baird AE, Van Dyke TE, Jones JA. Does periodontal treatment improve glycemic control in diabetic patients? A meta-analysis of intervention studies. J Dent Res. 2005;84(12):1154–9.PubMedPubMedCentralCrossRefGoogle Scholar
  73. 73.
    Darré L, Vergnes JN, Gourdy P, Sixou M. Efficacy of periodontal treatment on glycaemic control in diabetic patients: a meta-analysis of interventional studies. Diabetes Metab. 2008;34(5):497–506.PubMedCrossRefGoogle Scholar
  74. 74.
    Simpson TC, Needleman I, Wild SH, Moles DR, Mills EJ. Treatment of periodontal disease for glycaemic control in people with diabetes. Cochrane Database Syst Rev. 2010;5, CD004714.Google Scholar
  75. 75.
    Teeuw WJ, Gerdes VE, Loos BG. Effect of periodontal treatment on glycemic control of diabetic patients: a systematic review and meta-analysis. Diabetes Care. 2010;33(2):421–7.PubMedPubMedCentralCrossRefGoogle Scholar
  76. 76.
    Engebretson S, Kocher T. Evidence that periodontal treatment improves diabetes outcomes: a systematic review and meta-analysis. J Periodontol. 2013;84 Suppl 4:S153–69.PubMedPubMedCentralGoogle Scholar
  77. 77.
    Wang X, Han X, Guo X, Luo X, Wang D. The effect of periodontal treatment on hemoglobin a1c levels of diabetic patients: a systematic review and meta-analysis. PLoS One. 2014;9(9), e108412.PubMedPubMedCentralCrossRefGoogle Scholar
  78. 78.
    Simpson TC, Weldon JC, Worthington HV, Needleman I, Wild SH, Moles DR, et al. Treatment of periodontal disease for glycaemic control in people with diabetes mellitus. Cochrane Database Syst Rev. 2015;11, CD004714.Google Scholar
  79. 79.
    Corbella S, Francetti L, Taschieri S, De Siena F, Fabbro MD. Effect of periodontal treatment on glycemic control of patients with diabetes: a systematic review and meta-analysis. J Diabetes Investig. 2013;4(5):502–9.PubMedPubMedCentralCrossRefGoogle Scholar
  80. 80.
    Wolf D, Lalla E. The influence of periodontal disease on glycemic control in diabetes. In: Lamster I, editor. Diabetes mellitus and oral health: an interprofessional approach. Ames: Wiley Blackwell; 2014.Google Scholar
  81. 81.
    Engebretson SP, Hyman LG, Michalowicz BS, Schoenfeld ER, Gelato MC, Hou W, et al. The effect of nonsurgical periodontal therapy on hemoglobin A1c levels in persons with type 2 diabetes and chronic periodontitis: a randomized clinical trial. JAMA. 2013;310(23):2523–32.PubMedPubMedCentralCrossRefGoogle Scholar
  82. 82.
    Islam SA, Seo M, Lee YS, Moon SS. Association of periodontitis with insulin resistance, β-cell function, and impaired fasting glucose before onset of diabetes. Endocr J. 2015;62:981–9.PubMedCrossRefGoogle Scholar
  83. 83.
    Demmer RT, Jacobs DR, Desvarieux M. Periodontal disease and incident type 2 diabetes: results from the First National Health and Nutrition Examination Survey and its epidemiologic follow-up study. Diabetes Care. 2008;31(7):1373–9.PubMedPubMedCentralCrossRefGoogle Scholar
  84. 84.
    Chiu SY, Lai H, Yen AM, Fann JC, Chen LS, Chen HH. Temporal sequence of the bidirectional relationship between hyperglycemia and periodontal disease: a community-based study of 5,885 Taiwanese aged 35–44 years (KCIS No. 32). Acta Diabetol. 2015;52(1):123–31.PubMedCrossRefGoogle Scholar
  85. 85.
    Morita I, Inagaki K, Nakamura F, Noguchi T, Matsubara T, Yoshii S, et al. Relationship between periodontal status and levels of glycated hemoglobin. J Dent Res. 2012;91(2):161–6.PubMedCrossRefGoogle Scholar
  86. 86.
    Ide R, Hoshuyama T, Wilson D, Takahashi K, Higashi T. Periodontal disease and incident diabetes: a seven-year study. J Dent Res. 2011;90(1):41–6.PubMedCrossRefGoogle Scholar
  87. 87.
    Saito T, Shimazaki Y, Kiyohara Y, Kato I, Kubo M, Iida M, et al. The severity of periodontal disease is associated with the development of glucose intolerance in non-diabetics: the Hisayama study. J Dent Res. 2004;83(6):485–90.PubMedCrossRefGoogle Scholar
  88. 88.
    Alberti G, Zimmet P, Shaw J, Grundy S. Metabolic Syndrome: The IDF consensus worldwide definition of Metabolic Syndrome. In: Federation ID, editor. Brussels: IDF Communications; 2006. p. 1–24. http://www.idf.org/webdata/docs/IDF_Meta_def_final.pdf
  89. 89.
    Morita T, Yamazaki Y, Mita A, Takada K, Seto M, Nishinoue N, et al. A cohort study on the association between periodontal disease and the development of metabolic syndrome. J Periodontol. 2010;81(4):512–9.PubMedCrossRefGoogle Scholar
  90. 90.
    Heitz-Mayfield LJ. Disease progression: identification of high-risk groups and individuals for periodontitis. J Clin Periodontol. 2005;32 Suppl 6:196–209.PubMedCrossRefGoogle Scholar
  91. 91.
    Research, Science and Therapy Committee of the American Academy of Periodontology. Position paper: tobacco use and the periodontal patient. J Periodontol. 1999;70(11):1419–27.CrossRefGoogle Scholar
  92. 92.
    Orbak R, Tezel A, Canakçi V, Demir T. The influence of smoking and non-insulin-dependent diabetes mellitus on periodontal disease. J Int Med Res. 2002;30(2):116–25.PubMedCrossRefGoogle Scholar
  93. 93.
    Grossi SG, Skrepcinski FB, DeCaro T, Zambon JJ, Cummins D, Genco RJ. Response to periodontal therapy in diabetics and smokers. J Periodontol. 1996;67 Suppl 10:1094–102.PubMedCrossRefGoogle Scholar
  94. 94.
    Preshaw PM, Heasman L, Stacey F, Steen N, McCracken GI, Heasman PA. The effect of quitting smoking on chronic periodontitis. J Clin Periodontol. 2005;32(8):869–79.PubMedCrossRefGoogle Scholar
  95. 95.
    Preshaw P, Chambrone L, K N. Smoking and periodontal disease. In: Newman M, Takei H, Klokkevold P, Carranza F, editors. Carranza’s clinical periodontology. 12th ed. St. Louis: Elsevier Saunders; 2015. p. 1 online resource (xix, 818, 136 pages).Google Scholar
  96. 96.
    Rosa EF, Corraini P, de Carvalho VF, Inoue G, Gomes EF, Lotufo JP, et al. A prospective 12-month study of the effect of smoking cessation on periodontal clinical parameters. J Clin Periodontol. 2011;38(6):562–71.PubMedCrossRefGoogle Scholar
  97. 97.
    Ide R, Hoshuyama T, Takahashi K. The effect of periodontal disease on medical and dental costs in a middle-aged Japanese population: a longitudinal worksite study. J Periodontol. 2007;78(11):2120–6.PubMedCrossRefGoogle Scholar
  98. 98.
    Saremi A, Nelson RG, Tulloch-Reid M, Hanson RL, Sievers ML, Taylor GW, et al. Periodontal disease and mortality in type 2 diabetes. Diabetes Care. 2005;28(1):27–32.PubMedCrossRefGoogle Scholar
  99. 99.
    Shultis WA, Weil EJ, Looker HC, Curtis JM, Shlossman M, Genco RJ, et al. Effect of periodontitis on overt nephropathy and end-stage renal disease in type 2 diabetes. Diabetes Care. 2007;30(2):306–11.PubMedCrossRefGoogle Scholar
  100. 100.
    Varon FN. Effect of periodontitis on overt nephropathy and end-stage renal disease in type 2 diabetes: response to Shultis et al. Diabetes Care. 2007;30(12), e138; author reply e9.PubMedCrossRefGoogle Scholar
  101. 101.
    Thorstensson H, Kuylenstierna J, Hugoson A. Medical status and complications in relation to periodontal disease experience in insulin-dependent diabetics. J Clin Periodontol. 1996;23(3 Pt 1):194–202.PubMedCrossRefGoogle Scholar
  102. 102.
    Banthia R, Raje S, Banthia P, Saral SK, Singh P, Gupta S. Evaluation of the association between periodontal disease and diabetic retinopathy. Gen Dent. 2014;62(6):e28–32.PubMedGoogle Scholar
  103. 103.
    Noma H, Sakamoto I, Mochizuki H, Tsukamoto H, Minamoto A, Funatsu H, et al. Relationship between periodontal disease and diabetic retinopathy. Diabetes Care. 2004;27(2):615.PubMedCrossRefGoogle Scholar
  104. 104.
    Borgnakke WS, Anderson PF, Shannon C, Jivanescu A. Is there a relationship between oral health and diabetic neuropathy? Curr Diab Rep. 2015;15(11):93.PubMedCrossRefGoogle Scholar
  105. 105.
    Abrao L, Chagas JK, Schmid H. Periodontal disease and risk for neuropathic foot ulceration in type 2 diabetes. Diabetes Res Clin Pract. 2010;90(1):34–9.PubMedCrossRefGoogle Scholar
  106. 106.
    Figuero E, Carrillo-de-Albornoz A, Martín C, Tobías A, Herrera D. Effect of pregnancy on gingival inflammation in systemically healthy women: a systematic review. J Clin Periodontol. 2013;40(5):457–73.PubMedCrossRefGoogle Scholar
  107. 107.
    Wu M, Chen SW, Jiang SY. Relationship between gingival inflammation and pregnancy. Mediators Inflamm. 2015;2015:623427.PubMedPubMedCentralGoogle Scholar
  108. 108.
    Mealey BL, Moritz AJ. Hormonal influences: effects of diabetes mellitus and endogenous female sex steroid hormones on the periodontium. Periodontol 2000. 2003;32:59–81.PubMedCrossRefGoogle Scholar
  109. 109.
    Silk H, Douglass AB, Douglass JM, Silk L. Oral health during pregnancy. Am Fam Physician. 2008;77(8):1139–44.PubMedGoogle Scholar
  110. 110.
    Sills ES, Zegarelli DJ, Hoschander MM, Strider WE. Clinical diagnosis and management of hormonally responsive oral pregnancy tumor (pyogenic granuloma). J Reprod Med. 1996;41(7):467–70.PubMedGoogle Scholar
  111. 111.
    Offenbacher S, Katz V, Fertik G, Collins J, Boyd D, Maynor G, et al. Periodontal infection as a possible risk factor for preterm low birth weight. J Periodontol. 1996;67 Suppl 10:1103–13.PubMedCrossRefGoogle Scholar
  112. 112.
    Sanz M, Kornman K, workshop WgojEA. Periodontitis and adverse pregnancy outcomes: consensus report of the Joint EFP/AAP Workshop on Periodontitis and Systemic Diseases. J Clin Periodontol. 2013;40 Suppl 14:S164–9.PubMedGoogle Scholar
  113. 113.
    Buduneli N, Baylas H, Buduneli E, Türkoğlu O, Köse T, Dahlen G. Periodontal infections and pre-term low birth weight: a case–control study. J Clin Periodontol. 2005;32(2):174–81.PubMedCrossRefGoogle Scholar
  114. 114.
    Bansal M, Khatri M, Kumar A, Bhatia G. Relationship between maternal periodontal status and preterm low birth weight. Rev Obstet Gynecol. 2013;6(3–4):135–40.PubMedPubMedCentralGoogle Scholar
  115. 115.
    Boggess KA, Lieff S, Murtha AP, Moss K, Beck J, Offenbacher S. Maternal periodontal disease is associated with an increased risk for preeclampsia. Obstet Gynecol. 2003;101(2):227–31.PubMedGoogle Scholar
  116. 116.
    Surdacka A, Ciężka E, Pioruńska-Stolzmann M, Wender-Ożegowska E, Korybalska K, Kawka E, et al. Relation of salivary antioxidant status and cytokine levels to clinical parameters of oral health in pregnant women with diabetes. Arch Oral Biol. 2011;56(5):428–36.PubMedCrossRefGoogle Scholar
  117. 117.
    Novak KF, Taylor GW, Dawson DR, Ferguson JE, Novak MJ. Periodontitis and gestational diabetes mellitus: exploring the link in NHANES III. J Public Health Dent. 2006;66(3):163–8.PubMedCrossRefGoogle Scholar
  118. 118.
    Xiong X, Buekens P, Vastardis S, Pridjian G. Periodontal disease and gestational diabetes mellitus. Am J Obstet Gynecol. 2006;195(4):1086–9.PubMedCrossRefGoogle Scholar
  119. 119.
    Xiong X, Elkind-Hirsch KE, Vastardis S, Delarosa RL, Pridjian G, Buekens P. Periodontal disease is associated with gestational diabetes mellitus: a case-control study. J Periodontol. 2009;80(11):1742–9.PubMedPubMedCentralCrossRefGoogle Scholar
  120. 120.
    Chokwiriyachit A, Dasanayake AP, Suwannarong W, Hormdee D, Sumanonta G, Prasertchareonsuk W, et al. Periodontitis and gestational diabetes mellitus in non-smoking females. J Periodontol. 2013;84(7):857–62.PubMedCrossRefGoogle Scholar
  121. 121.
    Gogeneni H, Buduneli N, Ceyhan-Öztürk B, Gümüş P, Akcali A, Zeller I, et al. Increased infection with key periodontal pathogens during gestational diabetes mellitus. J Clin Periodontol. 2015;42(6):506–12.PubMedPubMedCentralCrossRefGoogle Scholar
  122. 122.
    Dasanayake AP, Chhun N, Tanner AC, Craig RG, Lee MJ, Moore AF, et al. Periodontal pathogens and gestational diabetes mellitus. J Dent Res. 2008;87(4):328–33.PubMedPubMedCentralCrossRefGoogle Scholar
  123. 123.
    Esteves Lima RP, Miranda Cota LO, Costa FO. Association between periodontitis and gestational diabetes mellitus: a case-control study. J Periodontol. 2013;84(9):1257–65.PubMedCrossRefGoogle Scholar
  124. 124.
    Esteves Lima RP, Cyrino RM, de Carvalho Dutra B, Oliveira da Silveira J, Martins CC, Miranda Cota LO, et al. Association between periodontitis and gestational diabetes mellitus: systematic review and meta-analysis. J Periodontol. 2016;87(1):48–57.PubMedCrossRefGoogle Scholar
  125. 125.
    Xie Y, Xiong X, Elkind-Hirsch KE, Pridjian G, Maney P, Delarosa RL, et al. Prepregnancy obesity and periodontitis among pregnant females with and without gestational diabetes mellitus. J Periodontol. 2014;85(7):890–8.PubMedCrossRefGoogle Scholar
  126. 126.
    Michalowicz BS, Hodges JS, DiAngelis AJ, Lupo VR, Novak MJ, Ferguson JE, et al. Treatment of periodontal disease and the risk of preterm birth. N Engl J Med. 2006;355(18):1885–94.PubMedCrossRefGoogle Scholar
  127. 127.
    Hujoel PP, Lydon-Rochelle M, Robertson PB, del Aguila MA. Cessation of periodontal care during pregnancy: effect on infant birthweight. Eur J Oral Sci. 2006;114(1):2–7.PubMedCrossRefGoogle Scholar
  128. 128.
    Amerongen AV, Veerman EC. Saliva – the defender of the oral cavity. Oral Dis. 2002;8(1):12–22.PubMedCrossRefGoogle Scholar
  129. 129.
    Gråhn E, Tenovuo J, Lehtonen OP, Eerola E, Vilja P. Antimicrobial systems of human whole saliva in relation to dental caries, cariogenic bacteria, and gingival inflammation in young adults. Acta Odontol Scand. 1988;46(2):67–74.PubMedCrossRefGoogle Scholar
  130. 130.
    Pedersen AM, Bardow A, Jensen SB, Nauntofte B. Saliva and gastrointestinal functions of taste, mastication, swallowing and digestion. Oral Dis. 2002;8(3):117–29.PubMedCrossRefGoogle Scholar
  131. 131.
    Fox PC, Busch KA, Baum BJ. Subjective reports of xerostomia and objective measures of salivary gland performance. J Am Dent Assoc. 1987;115(4):581–4.PubMedCrossRefGoogle Scholar
  132. 132.
    Malicka B, Kaczmarek U, Skośkiewicz-Malinowska K. Prevalence of xerostomia and the salivary flow rate in diabetic patients. Adv Clin Exp Med. 2014;23(2):225–33.PubMedCrossRefGoogle Scholar
  133. 133.
    Moore PA, Guggenheimer J, Etzel KR, Weyant RJ, Orchard T. Type 1 diabetes mellitus, xerostomia, and salivary flow rates. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2001;92(3):281–91.PubMedCrossRefGoogle Scholar
  134. 134.
    Mata AD, Marques D, Rocha S, Francisco H, Santos C, Mesquita MF, et al. Effects of diabetes mellitus on salivary secretion and its composition in the human. Mol Cell Biochem. 2004;261(1–2):137–42.PubMedCrossRefGoogle Scholar
  135. 135.
    Carda C, Carranza M, Arriaga A, Díaz A, Peydró A, Gomez de Ferraris ME. Structural differences between alcoholic and diabetic parotid sialosis. Med Oral Patol Oral Cir Bucal. 2005;10(4):309–14.PubMedGoogle Scholar
  136. 136.
    Chavez EM, Taylor GW, Borrell LN, Ship JA. Salivary function and glycemic control in older persons with diabetes. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2000;89(3):305–11.PubMedCrossRefGoogle Scholar
  137. 137.
    Scully C. Drug effects on salivary glands: dry mouth. Oral Dis. 2003;9(4):165–76.PubMedCrossRefGoogle Scholar
  138. 138.
    Aliko A, Wolff A, Dawes C, Aframian D, Proctor G, Ekström J, et al. World workshop on oral medicine VI: clinical implications of medication-induced salivary gland dysfunction. Oral Surg Oral Med Oral Pathol Oral Radiol. 2015;120(2):185–206.PubMedCrossRefGoogle Scholar
  139. 139.
    Lm S. Drugs, dry mouth, and dentistry. In: Sreebny L, Vissink A, editors. Dry mouth, the malevolent symptom: a clinical guide. Ames: Wiley Blackwell; 2010. p. 89–191.Google Scholar
  140. 140.
    Mandel L, Hamele-Bena D. Alcoholic parotid sialadenosis. J Am Dent Assoc. 1997;128(10):1411–5.PubMedCrossRefGoogle Scholar
  141. 141.
    Chilla R. Sialadenosis of the salivary glands of the head. Studies on the physiology and pathophysiology of parotid secretion. Adv Otorhinolaryngol. 1981;26:1–38.PubMedGoogle Scholar
  142. 142.
    Donath K, Seifert G. Ultrastructural studies of the parotid glands in sialadenosis. Virchows Arch A Pathol Anat Histol. 1975;365(2):119–35.PubMedCrossRefGoogle Scholar
  143. 143.
    Mandel L, Patel S. Sialadenosis associated with diabetes mellitus: a case report. J Oral Maxillofac Surg. 2002;60(6):696–8.PubMedCrossRefGoogle Scholar
  144. 144.
    Mandel L, Khelemsky R. Asymptomatic bilateral facial swelling. J Am Dent Assoc. 2012;143(11):1205–8.PubMedCrossRefGoogle Scholar
  145. 145.
    Ihrler S, Rath C, Zengel P, Kirchner T, Harrison JD, Weiler C. Pathogenesis of sialadenosis: possible role of functionally deficient myoepithelial cells. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2010;110(2):218–23.PubMedCrossRefGoogle Scholar
  146. 146.
    Russotto SB. Asymptomatic parotid gland enlargement in diabetes mellitus. Oral Surg Oral Med Oral Pathol. 1981;52(6):594–8.PubMedCrossRefGoogle Scholar
  147. 147.
    Scully C, Bagán JV, Eveson JW, Barnard N, Turner FM. Sialosis: 35 cases of persistent parotid swelling from two countries. Br J Oral Maxillofac Surg. 2008;46(6):468–72.PubMedCrossRefGoogle Scholar
  148. 148.
    Lilliu MA, Solinas P, Cossu M, Puxeddu R, Loy F, Isola R, et al. Diabetes causes morphological changes in human submandibular gland: a morphometric study. J Oral Pathol Med. 2015;44(4):291–5.PubMedCrossRefGoogle Scholar
  149. 149.
    Lilliu MA, Loy F, Cossu M, Solinas P, Isola R, Isola M. Morphometric study of diabetes related alterations in human parotid gland and comparison with submandibular gland. Anat Rec (Hoboken). 2015;298(11):1911–8.CrossRefGoogle Scholar
  150. 150.
    Merlo C, Bohl L, Carda C, Gómez de Ferraris ME, Carranza M. Parotid sialosis: morphometrical analysis of the glandular parenchyme and stroma among diabetic and alcoholic patients. J Oral Pathol Med. 2010;39(1):10–5.PubMedCrossRefGoogle Scholar
  151. 151.
    Yakubov Y, Mandel L. Bilateral parotid swelling in polycystic ovarian syndrome. J Oral Maxillofac Surg. 2016;74(5):991–4. doi:10.1016/j.joms.2015.10.026.Google Scholar
  152. 152.
    Fox PC. Autoimmune diseases and Sjogren’s syndrome: an autoimmune exocrinopathy. Ann N Y Acad Sci. 2007;1098:15–21.PubMedCrossRefGoogle Scholar
  153. 153.
    Dodds MW, Johnson DA, Yeh CK. Health benefits of saliva: a review. J Dent. 2005;33(3):223–33.PubMedCrossRefGoogle Scholar
  154. 154.
    Carneiro VL, Fraiz FC, Ferreira FM, Pintarelli TP, Oliveira AC, Boguszewski MC. The influence of glycemic control on the oral health of children and adolescents with diabetes mellitus type 1. Arch Endocrinol Metab. 2015;59(6):535–40.PubMedCrossRefGoogle Scholar
  155. 155.
    Rai K, Hegde AM, Kamath A, Shetty S. Dental caries and salivary alterations in Type I diabetes. J Clin Pediatr Dent. 2011;36(2):181–4.PubMedCrossRefGoogle Scholar
  156. 156.
    Siudikiene J, Machiulskiene V, Nyvad B, Tenovuo J, Nedzelskiene I. Dental caries and salivary status in children with type 1 diabetes mellitus, related to the metabolic control of the disease. Eur J Oral Sci. 2006;114(1):8–14.PubMedCrossRefGoogle Scholar
  157. 157.
    Gupta VK, Malhotra S, Sharma V, Hiremath SS. The influence of insulin dependent diabetes mellitus on dental caries and salivary flow. Int J Chronic Dis. 2014;2014:790898.PubMedPubMedCentralGoogle Scholar
  158. 158.
    Busato IM, Ignácio SA, Brancher JA, Moysés ST, Azevedo-Alanis LR. Impact of clinical status and salivary conditions on xerostomia and oral health-related quality of life of adolescents with type 1 diabetes mellitus. Community Dent Oral Epidemiol. 2012;40(1):62–9.PubMedCrossRefGoogle Scholar
  159. 159.
    Vasconcelos AC, Soares MS, Almeida PC, Soares TC. Comparative study of the concentration of salivary and blood glucose in type 2 diabetic patients. J Oral Sci. 2010;52(2):293–8.PubMedCrossRefGoogle Scholar
  160. 160.
    Jawed M, Khan RN, Shahid SM, Azhar A. Protective effects of salivary factors in dental caries in diabetic patients of Pakistan. Exp Diabetes Res. 2012;2012:947304.PubMedPubMedCentralCrossRefGoogle Scholar
  161. 161.
    Kogawa EM, Grisi DC, Falcão DP, Amorim IA, Rezende TM, da Silva IC, et al. Salivary function impairment in type 2 Diabetes patients associated with concentration and genetic polymorphisms of chromogranin A. Clin Oral Investig. 2016;1–13. [Epub ahead of print]. PMID: 26750135.Google Scholar
  162. 162.
    Montaldo L, Montaldo P, Papa A, Caramico N, Toro G. Effects of saliva substitutes on oral status in patients with type 2 diabetes. Diabet Med. 2010;27(11):1280–3.PubMedCrossRefGoogle Scholar
  163. 163.
    Dodds MW, Yeh CK, Johnson DA. Salivary alterations in type 2 (non-insulin-dependent) diabetes mellitus and hypertension. Community Dent Oral Epidemiol. 2000;28(5):373–81.PubMedCrossRefGoogle Scholar
  164. 164.
    Lasisi TJ, Fasanmade AA. Comparative analysis of salivary glucose and electrolytes in diabetic individuals with periodontitis. Ann Ib Postgrad Med. 2012;10(1):25–30.PubMedPubMedCentralGoogle Scholar
  165. 165.
    Malicka B, Kaczmarek U, Skośkiewicz-Malinowska K. Selected antibacterial factors in the saliva of diabetic patients. Arch Oral Biol. 2015;60(3):425–31.PubMedCrossRefGoogle Scholar
  166. 166.
    Meurman JH, Collin HL, Niskanen L, Töyry J, Alakuijala P, Keinänen S, et al. Saliva in non-insulin-dependent diabetic patients and control subjects: the role of the autonomic nervous system. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 1998;86(1):69–76.PubMedCrossRefGoogle Scholar
  167. 167.
    Mascarenhas P, Fatela B, Barahona I. Effect of diabetes mellitus type 2 on salivary glucose – a systematic review and meta-analysis of observational studies. PLoS One. 2014;9(7), e101706.PubMedPubMedCentralCrossRefGoogle Scholar
  168. 168.
    Mussavira S, Dharmalingam M, Omana Sukumaran B. Salivary glucose and antioxidant defense markers in type II diabetes mellitus. Turk J Med Sci. 2015;45(1):141–7.PubMedCrossRefGoogle Scholar
  169. 169.
    Twetman S, Johansson I, Birkhed D, Nederfors T. Caries incidence in young type 1 diabetes mellitus patients in relation to metabolic control and caries-associated risk factors. Caries Res. 2002;36(1):31–5.PubMedCrossRefGoogle Scholar
  170. 170.
    Barnes VM, Kennedy AD, Panagakos F, Devizio W, Trivedi HM, Jönsson T, et al. Global metabolomic analysis of human saliva and plasma from healthy and diabetic subjects, with and without periodontal disease. PLoS One. 2014;9(8), e105181.PubMedPubMedCentralCrossRefGoogle Scholar
  171. 171.
    Twetman S, Nederfors T, Stahl B, Aronson S. Two-year longitudinal observations of salivary status and dental caries in children with insulin-dependent diabetes mellitus. Pediatr Dent. 1992;14(3):184–8.PubMedGoogle Scholar
  172. 172.
    Karjalainen KM, Knuuttila ML, Käär ML. Relationship between caries and level of metabolic balance in children and adolescents with insulin-dependent diabetes mellitus. Caries Res. 1997;31(1):13–8.PubMedCrossRefGoogle Scholar
  173. 173.
    Carda C, Mosquera-Lloreda N, Salom L, Gomez de Ferraris ME, Peydró A. Structural and functional salivary disorders in type 2 diabetic patients. Med Oral Patol Oral Cir Bucal. 2006;11(4):E309–14.PubMedGoogle Scholar
  174. 174.
    Collin HL, Sorsa T, Meurman JH, Niskanen L, Salo T, Rönkä H, et al. Salivary matrix metalloproteinase (MMP-8) levels and gelatinase (MMP-9) activities in patients with type 2 diabetes mellitus. J Periodontal Res. 2000;35(5):259–65.PubMedCrossRefGoogle Scholar
  175. 175.
    Lamster I. Non-periodontal oral complications of diabetes mellitus. In: Lamster I, editor. Diabetes mellitus and oral health: an interprofessional approach. Ames: Wiley Blackwell; 2014. p. 162.Google Scholar
  176. 176.
    Rao PV, Reddy AP, Lu X, Dasari S, Krishnaprasad A, Biggs E, et al. Proteomic identification of salivary biomarkers of type-2 diabetes. J Proteome Res. 2009;8(1):239–45.PubMedCrossRefGoogle Scholar
  177. 177.
    Border MB, Schwartz S, Carlson J, Dibble CF, Kohltfarber H, Offenbacher S, et al. Exploring salivary proteomes in edentulous patients with type 2 diabetes. Mol Biosyst. 2012;8(4):1304–10.PubMedCrossRefGoogle Scholar
  178. 178.
    Dye BA, Thornton-Evans G, Li X, Iafolla TJ. Dental caries and sealant prevalence in children and adolescents in the United States, 2011–2012. NCHS Data Brief. 2015;191:1–8. http://www.cdc.gov/nchs/products/databriefs/db191.htm.
  179. 179.
    National Center for Health Statistics: Third National Health and Nutrition Survey (NHANES III) reference manuals and reports. Hyattsville: NCHS, U.S. Department of Health and Human Services, Public Health Service, Centers for Disease Control and Prevention; 1996.Google Scholar
  180. 180.
    Featherstone JD. Dental caries: a dynamic disease process. Aust Dent J. 2008;53(3):286–91.PubMedCrossRefGoogle Scholar
  181. 181.
    Moynihan PJ, Kelly SA. Effect on caries of restricting sugars intake: systematic review to inform WHO guidelines. J Dent Res. 2014;93(1):8–18.PubMedPubMedCentralCrossRefGoogle Scholar
  182. 182.
    Novotna M, Podzimek S, Broukal Z, Lencova E, Duskova J. Periodontal diseases and dental caries in children with type 1 diabetes mellitus. Mediators Inflamm. 2015;2015:379626.PubMedPubMedCentralCrossRefGoogle Scholar
  183. 183.
    Ismail AF, McGrath CP, Yiu CK. Oral health of children with type 1 diabetes mellitus: a systematic review. Diabetes Res Clin Pract. 2015;108(3):369–81.PubMedCrossRefGoogle Scholar
  184. 184.
    Garton BJ, Ford PJ. Root caries and diabetes: risk assessing to improve oral and systemic health outcomes. Aust Dent J. 2012;57(2):114–22.PubMedCrossRefGoogle Scholar
  185. 185.
    Miralles L, Silvestre FJ, Hernández-Mijares A, Bautista D, Llambes F, Grau D. Dental caries in type 1 diabetics: influence of systemic factors of the disease upon the development of dental caries. Med Oral Patol Oral Cir Bucal. 2006;11(3):E256–60.PubMedGoogle Scholar
  186. 186.
    Miko S, Ambrus SJ, Sahafian S, Dinya E, Tamas G, Albrecht MG. Dental caries and adolescents with type 1 diabetes. Br Dent J. 2010;208(6), E12.PubMedCrossRefGoogle Scholar
  187. 187.
    Edblad E, Lundin SA, Sjödin B, Aman J. Caries and salivary status in young adults with type 1 diabetes. Swed Dent J. 2001;25(2):53–60.PubMedGoogle Scholar
  188. 188.
    Jones RB, McCallum RM, Kay EJ, Kirkin V, McDonald P. Oral health and oral health behaviour in a population of diabetic outpatient clinic attenders. Community Dent Oral Epidemiol. 1992;20(4):204–7.PubMedCrossRefGoogle Scholar
  189. 189.
    Lalla E, Cheng B, Lal S, Tucker S, Greenberg E, Goland R, et al. Periodontal changes in children and adolescents with diabetes: a case-control study. Diabetes Care. 2006;29(2):295–9.PubMedCrossRefGoogle Scholar
  190. 190.
    Arrieta-Blanco JJ, Bartolomé-Villar B, Jiménez-Martinez E, Saavedra-Vallejo P, Arrieta-Blanco FJ. Bucco-dental problems in patients with diabetes mellitus (I): index of plaque and dental caries. Med Oral. 2003;8(2):97–109.PubMedGoogle Scholar
  191. 191.
    Orbak R, Simsek S, Orbak Z, Kavrut F, Colak M. The influence of type-1 diabetes mellitus on dentition and oral health in children and adolescents. Yonsei Med J. 2008;49(3):357–65.PubMedPubMedCentralCrossRefGoogle Scholar
  192. 192.
    Tagelsir A, Cauwels R, van Aken S, Vanobbergen J, Martens LC. Dental caries and dental care level (restorative index) in children with diabetes mellitus type 1. Int J Pediatr Dent. 2011;21(1):13–22.CrossRefGoogle Scholar
  193. 193.
    Siudikiene J, Maciulskiene V, Nedzelskiene I. Dietary and oral hygiene habits in children with type I diabetes mellitus related to dental caries. Stomatologija. 2005;7(2):58–62.PubMedGoogle Scholar
  194. 194.
    Bolgül BS, Celenk S, Ayna BE, Atakul F, Uysal E. Evaluation of caries risk factors and effects of a fluoride-releasing adhesive material in children with insulin-dependent diabetes mellitus (IDDM): initial first-year results. Acta Odontol Scand. 2004;62(5):289–92.PubMedCrossRefGoogle Scholar
  195. 195.
    Saes Busato IM, Bittencourt MS, Machado MA, Grégio AM, Azevedo-Alanis LR. Association between metabolic control and oral health in adolescents with type 1 diabetes mellitus. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2010;109(3):e51–6.PubMedCrossRefGoogle Scholar
  196. 196.
    Syrjälä AM, Niskanen MC, Ylöstalo P, Knuuttila ML. Metabolic control as a modifier of the association between salivary factors and dental caries among diabetic patients. Caries Res. 2003;37(2):142–7.PubMedCrossRefGoogle Scholar
  197. 197.
    Moore PA, Weyant RJ, Etzel KR, Guggenheimer J, Mongelluzzo MB, Myers DE, et al. Type 1 diabetes mellitus and oral health: assessment of coronal and root caries. Community Dent Oral Epidemiol. 2001;29(3):183–94.PubMedCrossRefGoogle Scholar
  198. 198.
    Lamster I. Non-periodontal oral complications of diabetes mellitus. In: Lamster I, editor. Diabetes mellitus and oral health: an interprofessional approach. Ames: Wiley Blackwell; 2014.CrossRefGoogle Scholar
  199. 199.
    Hintao J, Teanpaisan R, Chongsuvivatwong V, Dahlen G, Rattarasarn C. Root surface and coronal caries in adults with type 2 diabetes mellitus. Community Dent Oral Epidemiol. 2007;35(4):302–9.PubMedCrossRefGoogle Scholar
  200. 200.
    Lin BP, Taylor GW, Allen DJ, Ship JA. Dental caries in older adults with diabetes mellitus. Spec Care Dentist. 1999;19(1):8–14.PubMedCrossRefGoogle Scholar
  201. 201.
    Collin HL, Uusitupa M, Niskanen L, Koivisto AM, Markkanen H, Meurman JH. Caries in patients with non-insulin-dependent diabetes mellitus. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 1998;85(6):680–5.PubMedCrossRefGoogle Scholar
  202. 202.
    Närhi TO, Meurman JH, Odont D, Ainamo A, Tilvis R. Oral health in the elderly with non-insulin-dependent diabetes mellitus. Spec Care Dentist. 1996;16(3):116–22.PubMedCrossRefGoogle Scholar
  203. 203.
    Tavares M, Depaola P, Soparkar P, Joshipura K. The prevalence of root caries in a diabetic population. J Dent Res. 1991;70(6):979–83.PubMedCrossRefGoogle Scholar
  204. 204.
    Cherry-Peppers G, Ship JA. Oral health in patients with type II diabetes and impaired glucose tolerance. Diabetes Care. 1993;16(4):638–41.PubMedCrossRefGoogle Scholar
  205. 205.
    Guggenheimer J, Moore PA, Rossie K, Myers D, Mongelluzzo MB, Block HM, et al. Insulin-dependent diabetes mellitus and oral soft tissue pathologies: II. Prevalence and characteristics of Candida and candidal lesions. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2000;89(5):570–6.PubMedCrossRefGoogle Scholar
  206. 206.
    Albrecht M, Bánóczy J, Dinya E, Tamás G. Occurrence of oral leukoplakia and lichen planus in diabetes mellitus. J Oral Pathol Med. 1992;21(8):364–6.PubMedCrossRefGoogle Scholar
  207. 207.
    Dikshit RP, Ramadas K, Hashibe M, Thomas G, Somanathan T, Sankaranarayanan R. Association between diabetes mellitus and pre-malignant oral diseases: a cross sectional study in Kerala, India. Int J Cancer. 2006;118(2):453–7.PubMedCrossRefGoogle Scholar
  208. 208.
    Ujpál M, Matos O, Bíbok G, Somogyi A, Szabó G, Suba Z. Diabetes and oral tumors in Hungary: epidemiological correlations. Diabetes Care. 2004;27(3):770–4.PubMedCrossRefGoogle Scholar
  209. 209.
    Gong Y, Wei B, Yu L, Pan W. Type 2 diabetes mellitus and risk of oral cancer and precancerous lesions: a meta-analysis of observational studies. Oral Oncol. 2015;51(4):332–40.PubMedCrossRefGoogle Scholar
  210. 210.
    Tseng KS, Lin C, Lin YS, Weng SF. Risk of head and neck cancer in patients with diabetes mellitus: a retrospective cohort study in Taiwan. JAMA Otolaryngol Head Neck Surg. 2014;140(8):746–53.PubMedCrossRefGoogle Scholar
  211. 211.
    Lin CC, Chiang JH, Li CI, Liu CS, Lin WY, Hsieh TF, et al. Cancer risks among patients with type 2 diabetes: a 10-year follow-up study of a nationwide population-based cohort in Taiwan. BMC Cancer. 2014;14:381.PubMedPubMedCentralCrossRefGoogle Scholar
  212. 212.
    Geerlings SE, Hoepelman AI. Immune dysfunction in patients with diabetes mellitus (DM). FEMS Immunol Med Microbiol. 1999;26(3–4):259–65.PubMedCrossRefGoogle Scholar
  213. 213.
    Negrato CA, Tarzia O. Buccal alterations in diabetes mellitus. Diabetol Metab Syndr. 2010;2:3.PubMedPubMedCentralCrossRefGoogle Scholar
  214. 214.
    Neville BW. Oral and maxillofacial pathology. 4th ed. St. Louis: Saunders/Elsevier; 2015.Google Scholar
  215. 215.
    Al-Attas SA, Amro SO. Candidal colonization, strain diversity, and antifungal susceptibility among adult diabetic patients. Ann Saudi Med. 2010;30(2):101–8.PubMedPubMedCentralCrossRefGoogle Scholar
  216. 216.
    Lotfi-Kamran MH, Jafari AA, Falah-Tafti A, Tavakoli E, Falahzadeh MH. Candida colonization on the denture of diabetic and non-diabetic patients. Dent Res J (Isfahan). 2009;6(1):23–7.Google Scholar
  217. 217.
    Premkumar J, Ramani P, Chandrasekar T, Natesan A, Premkumar P. Detection of species diversity in oral Candida colonization and anti-fungal susceptibility among non-oral habit adult diabetic patients. J Nat Sci Biol Med. 2014;5(1):148–54.PubMedPubMedCentralCrossRefGoogle Scholar
  218. 218.
    Sanitá PV, Pavarina AC, Giampaolo ET, Silva MM, Mima EG, Ribeiro DG, et al. Candida spp. prevalence in well controlled type 2 diabetic patients with denture stomatitis. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2011;111(6):726–33.PubMedCrossRefGoogle Scholar
  219. 219.
    Kalapala L, Raghunath V, Reginald AB. Salivary factors, candidal colonization and strain diversity in type II diabetics. Nat J Lab Med. 2015;4(4):52–8.Google Scholar
  220. 220.
    Tapper-Jones LM, Aldred MJ, Walker DM, Hayes TM. Candidal infections and populations of Candida albicans in mouths of diabetics. J Clin Pathol. 1981;34(7):706–11.PubMedPubMedCentralCrossRefGoogle Scholar
  221. 221.
    Kumar BV, Padshetty NS, Bai KY, Rao MS. Prevalence of Candida in the oral cavity of diabetic subjects. J Assoc Physicians India. 2005;53:599–602.PubMedGoogle Scholar
  222. 222.
    Bremenkamp RM, Caris AR, Jorge AO, Back-Brito GN, Mota AJ, Balducci I, et al. Prevalence and antifungal resistance profile of Candida spp. oral isolates from patients with type 1 and 2 diabetes mellitus. Arch Oral Biol. 2011;56(6):549–55.PubMedCrossRefGoogle Scholar
  223. 223.
    Cavaleiro I, Proença L, Félix S, Salema-Oom M. Prevalence of yeast other than Candida albicans in denture wearers. J Prosthodont. 2013;22(5):351–7.PubMedCrossRefGoogle Scholar
  224. 224.
    Zomorodian K, Haghighi NN, Rajaee N, Pakshir K, Tarazooie B, Vojdani M, et al. Assessment of Candida species colonization and denture-related stomatitis in complete denture wearers. Med Mycol. 2011;49(2):208–11.PubMedCrossRefGoogle Scholar
  225. 225.
    Dorocka-Bobkowska B, Zozulinska-Ziolkiewicz D, Wierusz-Wysocka B, Hedzelek W, Szumala-Kakol A, Budtz-Jörgensen E. Candida-associated denture stomatitis in type 2 diabetes mellitus. Diabetes Res Clin Pract. 2010;90(1):81–6.PubMedCrossRefGoogle Scholar
  226. 226.
    Willis AM, Coulter WA, Fulton CR, Hayes JR, Bell PM, Lamey PJ. Oral candidal carriage and infection in insulin-treated diabetic patients. Diabet Med. 1999;16(8):675–9.PubMedCrossRefGoogle Scholar
  227. 227.
    Vasconcelos BC, Novaes M, Sandrini FA, Maranhão Filho AW, Coimbra LS. Prevalence of oral mucosa lesions in diabetic patients: a preliminary study. Braz J Otorhinolaryngol. 2008;74(3):423–8.PubMedCrossRefGoogle Scholar
  228. 228.
    Sashikumar R, Kannan R. Salivary glucose levels and oral candidal carriage in type II diabetics. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2010;109(5):706–11.PubMedCrossRefGoogle Scholar
  229. 229.
    Borgnakke WS. Salivary glucose levels are unable to predict oral candidiasis or monitor diabetes. J Evid Based Dent Pract. 2010;10(4):237–40.PubMedCrossRefGoogle Scholar
  230. 230.
    Darwazeh AM, Lamey PJ, Samaranayake LP, MacFarlane TW, Fisher BM, Macrury SM, et al. The relationship between colonisation, secretor status and in-vitro adhesion of Candida albicans to buccal epithelial cells from diabetics. J Med Microbiol. 1990;33(1):43–9.PubMedCrossRefGoogle Scholar
  231. 231.
    Samaranayake LP. Host factors and Oral Candidosis. In: Samaranayake LP, MacFarlane TW, editor. Oral Candidosis. London: Wright Butterworth; 1990:66-103.Google Scholar
  232. 232.
    Hibino K, Samaranayake LP, Hägg U, Wong RW, Lee W. The role of salivary factors in persistent oral carriage of Candida in humans. Arch Oral Biol. 2009;54(7):678–83.PubMedCrossRefGoogle Scholar
  233. 233.
    Gandara B, Morton T. Non-periodontal oral manifestations of diabetes: a framework for medical care providers. Diabetes Spectrum. 2011;24:199–205.CrossRefGoogle Scholar
  234. 234.
    Saini R, Al-Maweri SA, Saini D, Ismail NM, Ismail AR. Oral mucosal lesions in non oral habit diabetic patients and association of diabetes mellitus with oral precancerous lesions. Diabetes Res Clin Pract. 2010;89(3):320–6.PubMedCrossRefGoogle Scholar
  235. 235.
    Fisher BM, Lamey PJ, Samaranayake LP, MacFarlane TW, Frier BM. Carriage of Candida species in the oral cavity in diabetic patients: relationship to glycaemic control. J Oral Pathol. 1987;16(5):282–4.PubMedCrossRefGoogle Scholar
  236. 236.
    Webb BC, Thomas CJ, Willcox MD, Harty DW, Knox KW. Candida-associated denture stomatitis. Aetiology and management: a review. Part 1. Factors influencing distribution of Candida species in the oral cavity. Aust Dent J. 1998;43(1):45–50.PubMedCrossRefGoogle Scholar
  237. 237.
    Sahin I, Oksuz S, Sencan I, Gulcan A, Karabay O, Gulcan E, et al. Prevalence and risk factors for yeast colonization in adult diabetic patients. Ethiop Med J. 2005;43(2):103–9.PubMedGoogle Scholar
  238. 238.
    Aly FZ, Blackwell CC, Mackenzie DA, Weir DM, Clarke BF. Factors influencing oral carriage of yeasts among individuals with diabetes mellitus. Epidemiol Infect. 1992;109(3):507–18.PubMedPubMedCentralCrossRefGoogle Scholar
  239. 239.
    Chandler PT, Chandler SD. Pathogenic carrier rate in diabetes mellitus. Am J Med Sci. 1977;273(3):259–65.PubMedCrossRefGoogle Scholar
  240. 240.
    Hill LV, Tan MH, Pereira LH, Embil JA. Association of oral candidiasis with diabetic control. J Clin Pathol. 1989;42(5):502–5.PubMedPubMedCentralCrossRefGoogle Scholar
  241. 241.
    Belazi M, Velegraki A, Fleva A, Gidarakou I, Papanaum L, Baka D, et al. Candidal overgrowth in diabetic patients: potential predisposing factors. Mycoses. 2005;48(3):192–6.PubMedCrossRefGoogle Scholar
  242. 242.
    Regezi JA, Sciubba JJ, Jordan RCK. Oral pathology: clinical pathologic correlations. St. Louis: Elsevier/Saunders; 2012.Google Scholar
  243. 243.
    Manfredi M, McCullough MJ, Al-Karaawi ZM, Hurel SJ, Porter SR. The isolation, identification and molecular analysis of Candida spp. isolated from the oral cavities of patients with diabetes mellitus. Oral Microbiol Immunol. 2002;17(3):181–5.PubMedCrossRefGoogle Scholar
  244. 244.
    Sullivan DJ, Westerneng TJ, Haynes KA, Bennett DE, Coleman DC. Candida dubliniensis sp. nov.: phenotypic and molecular characterization of a novel species associated with oral candidosis in HIV-infected individuals. Microbiology. 1995;141(Pt 7):1507–21.PubMedCrossRefGoogle Scholar
  245. 245.
    Gonçalves RH, Miranda ET, Zaia JE, Giannini MJ. Species diversity of yeast in oral colonization of insulin-treated diabetes mellitus patients. Mycopathologia. 2006;162(2):83–9.PubMedCrossRefGoogle Scholar
  246. 246.
    Willis AM, Coulter WA, Sullivan DJ, Coleman DC, Hayes JR, Bell PM, et al. Isolation of C. dubliniensis from insulin-using diabetes mellitus patients. J Oral Pathol Med. 2000;29(2):86–90.PubMedCrossRefGoogle Scholar
  247. 247.
    Tekeli A, Dolapci I, Emral R, Cesur S. Candida carriage and Candida dubliniensis in oropharyngeal samples of type-1 diabetes mellitus patients. Mycoses. 2004;47(7):315–8.PubMedCrossRefGoogle Scholar
  248. 248.
    Melton JJ, Redding SW, Kirkpatrick WR, Reasner CA, Ocampo GL, Venkatesh A, et al. Recovery of Candida dubliniensis and other Candida species from the oral cavity of subjects with periodontitis who had well-controlled and poorly controlled type 2 diabetes: a pilot study. Spec Care Dentist. 2010;30(6):230–4.PubMedCrossRefGoogle Scholar
  249. 249.
    Guggenheimer J, Moore PA, Rossie K, Myers D, Mongelluzzo MB, Block HM, et al. Insulin-dependent diabetes mellitus and oral soft tissue pathologies. I. Prevalence and characteristics of non-candidal lesions. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2000;89(5):563–9.PubMedCrossRefGoogle Scholar
  250. 250.
    Farman A. Atrophic lesions of the tongue: a prevalence study among 176 diabetic patients. J Oral Pathol. 1976;5:255–64.PubMedCrossRefGoogle Scholar
  251. 251.
    Bastos AS, Leite AR, Spin-Neto R, Nassar PO, Massucato EM, Orrico SR. Diabetes mellitus and oral mucosa alterations: prevalence and risk factors. Diabetes Res Clin Pract. 2011;92(1):100–5.PubMedCrossRefGoogle Scholar
  252. 252.
    Silva MF, Barbosa KG, Pereira JV, Bento PM, Godoy GP, Gomes DQ. Prevalence of oral mucosal lesions among patients with diabetes mellitus types 1 and 2. An Bras Dermatol. 2015;90(1):49–53.PubMedPubMedCentralCrossRefGoogle Scholar
  253. 253.
    Al-Hashimi I, Schifter M, Lockhart PB, Wray D, Brennan M, Migliorati CA, et al. Oral lichen planus and oral lichenoid lesions: diagnostic and therapeutic considerations. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2007;103(Suppl):S25.e1–12.Google Scholar
  254. 254.
    Epstein JB, Wan LS, Gorsky M, Zhang L. Oral lichen planus: progress in understanding its malignant potential and the implications for clinical management. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2003;96(1):32–7.PubMedCrossRefGoogle Scholar
  255. 255.
    Romero MA, Seoane J, Varela-Centelles P, Diz-Dios P, Garcia-Pola MJ. Prevalence of diabetes mellitus amongst oral lichen planus patients. Clinical and pathological characteristics. Med Oral. 2002;7(2):121–9.PubMedGoogle Scholar
  256. 256.
    Seyhan M, Ozcan H, Sahin I, Bayram N, Karincaoğlu Y. High prevalence of glucose metabolism disturbance in patients with lichen planus. Diabetes Res Clin Pract. 2007;77(2):198–202.PubMedCrossRefGoogle Scholar
  257. 257.
    Borghelli RF, Pettinari IL, Chuchurru JA, Stirparo MA. Oral lichen planus in patients with diabetes. An epidemiologic study. Oral Surg Oral Med Oral Pathol. 1993;75(4):498–500.PubMedCrossRefGoogle Scholar
  258. 258.
    Van Dis ML, Parks ET. Prevalence of oral lichen planus in patients with diabetes mellitus. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 1995;79(6):696–700.PubMedCrossRefGoogle Scholar
  259. 259.
    Yuan A, Woo SB. Adverse drug events in the oral cavity. Oral Surg Oral Med Oral Pathol Oral Radiol. 2015;119(1):35–47.PubMedCrossRefGoogle Scholar
  260. 260.
    Kaomongkolgit R. Oral lichenoid drug reaction associated with antihypertensive and hypoglycemic drugs. J Drugs Dermatol. 2010;9(1):73–5.PubMedGoogle Scholar
  261. 261.
    Scully C, Bagan JV. Adverse drug reactions in the orofacial region. Crit Rev Oral Biol Med. 2004;15(4):221–39.PubMedCrossRefGoogle Scholar
  262. 262.
    Serrano-Sánchez P, Bagan JV, Jiménez-Soriano, Sarrión G. Drug-induced oral lichenoid reactions. A literature review. J Clin Exp Dent. 2010;2(2):e71–5.CrossRefGoogle Scholar
  263. 263.
    Lamey PJ, Gibson J, Barclay SC, Miller S. Grinspan’s syndrome: a drug-induced phenomenon? Oral Surg Oral Med Oral Pathol. 1990;70:184–5.PubMedCrossRefGoogle Scholar
  264. 264.
    Lodi G, Scully C, Carrozzo M, Griffiths M, Sugerman PB, Thongprasom K. Current controversies in oral lichen planus: report of an international consensus meeting. Part 2. Clinical management and malignant transformation. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2005;100(2):164–78.PubMedCrossRefGoogle Scholar
  265. 265.
    van der Waal I. Potentially malignant disorders of the oral and oropharyngeal mucosa; terminology, classification and present concepts of management. Oral Oncol. 2009;45(4–5):317–23.PubMedCrossRefGoogle Scholar
  266. 266.
    Pindborg J, Reichart P, Smith C, van der Waal I. Precancerous conditions. In: Organization WH, editor. Histological typing of cancer and precancer of the oral mucosa. 2nd ed. Berlin: Springer; 1997:1–87.Google Scholar
  267. 267.
    van der Meij EH, Mast H, van der Waal I. The possible premalignant character of oral lichen planus and oral lichenoid lesions: a prospective five-year follow-up study of 192 patients. Oral Oncol. 2007;43(8):742–8.PubMedCrossRefGoogle Scholar
  268. 268.
    Fitzpatrick SG, Hirsch SA, Gordon SC. The malignant transformation of oral lichen planus and oral lichenoid lesions: a systematic review. J Am Dent Assoc. 2014;145(1):45–56.PubMedCrossRefGoogle Scholar
  269. 269.
    Gandolfo S, Richiardi L, Carrozzo M, Broccoletti R, Carbone M, Pagano M, et al. Risk of oral squamous cell carcinoma in 402 patients with oral lichen planus: a follow-up study in an Italian population. Oral Oncol. 2004;40(1):77–83.PubMedCrossRefGoogle Scholar
  270. 270.
    Silverman S, Gorsky M, Lozada-Nur F. A prospective follow-up study of 570 patients with oral lichen planus: persistence, remission, and malignant association. Oral Surg Oral Med Oral Pathol. 1985;60(1):30–4.PubMedCrossRefGoogle Scholar
  271. 271.
    Casparis S, Borm JM, Tektas S, Kamarachev J, Locher MC, Damerau G, et al. Oral lichen planus (OLP), oral lichenoid lesions (OLL), oral dysplasia, and oral cancer: retrospective analysis of clinicopathological data from 2002–2011. Oral Maxillofac Surg. 2015;19(2):149–56.PubMedCrossRefGoogle Scholar
  272. 272.
    Eisenberg E. Oral lichen planus: a benign lesion. J Oral Maxillofac Surg. 2000;58(11):1278–85.PubMedCrossRefGoogle Scholar
  273. 273.
    Silverman S. Oral lichen planus: a potentially premalignant lesion. J Oral Maxillofac Surg. 2000;58(11):1286–8.PubMedCrossRefGoogle Scholar
  274. 274.
    Eisen D. The clinical features, malignant potential, and systemic associations of oral lichen planus: a study of 723 patients. J Am Acad Dermatol. 2002;46(2):207–14.PubMedCrossRefGoogle Scholar
  275. 275.
    Mignogna MD, Lo Muzio L, Lo Russo L, Fedele S, Ruoppo E, Bucci E. Clinical guidelines in early detection of oral squamous cell carcinoma arising in oral lichen planus: a 5-year experience. Oral Oncol. 2001;37(3):262–7.PubMedCrossRefGoogle Scholar
  276. 276.
    Mattsson U, Jontell M, Holmstrup P. Oral lichen planus and malignant transformation: is a recall of patients justified? Crit Rev Oral Biol Med. 2002;13(5):390–6.PubMedCrossRefGoogle Scholar
  277. 277.
    Dost F, Lê Cao KA, Ford PJ, Farah CS. A retrospective analysis of clinical features of oral malignant and potentially malignant disorders with and without oral epithelial dysplasia. Oral Surg Oral Med Oral Pathol Oral Radiol. 2013;116(6):725–33.PubMedCrossRefGoogle Scholar
  278. 278.
    Vairaktaris E, Spyridonidou S, Goutzanis L, Vylliotis A, Lazaris A, Donta I, et al. Diabetes and oral oncogenesis. Anticancer Res. 2007;27(6B):4185–93.PubMedGoogle Scholar
  279. 279.
    Onitilo AA, Engel JM, Glurich I, Stankowski RV, Williams GM, Doi SA. Diabetes and cancer II: role of diabetes medications and influence of shared risk factors. Cancer Causes Control. 2012;23(7):991–1008.PubMedPubMedCentralCrossRefGoogle Scholar
  280. 280.
    Gallagher EJ, LeRoith D. Epidemiology and molecular mechanisms tying obesity, diabetes, and the metabolic syndrome with cancer. Diabetes Care. 2013;36 Suppl 2:S233–9.PubMedPubMedCentralCrossRefGoogle Scholar
  281. 281.
    Liu CJ, Chang WJ, Chen CY, Sun FJ, Cheng HW, Chen TY, et al. Dynamic cellular and molecular modulations of diabetes mediated head and neck carcinogenesis. Oncotarget. 2015;6(30):29268–84.PubMedPubMedCentralGoogle Scholar
  282. 282.
    Dandona P, Thusu K, Cook S, Snyder B, Makowski J, Armstrong D, et al. Oxidative damage to DNA in diabetes mellitus. Lancet. 1996;347(8999):444–5.PubMedCrossRefGoogle Scholar
  283. 283.
    Valent F. Diabetes mellitus and cancer of the digestive organs: an Italian population-based cohort study. J Diabet Complications. 2015;29(8):1056–61.CrossRefGoogle Scholar
  284. 284.
    Anantharaman D, Marron M, Lagiou P, Samoli E, Ahrens W, Pohlabeln H, et al. Population attributable risk of tobacco and alcohol for upper aerodigestive tract cancer. Oral Oncol. 2011;47(8):725–31.PubMedCrossRefGoogle Scholar
  285. 285.
    Atchison EA, Gridley G, Carreon JD, Leitzmann MF, McGlynn KA. Risk of cancer in a large cohort of U.S. veterans with diabetes. Int J Cancer. 2011;128:635–43.PubMedPubMedCentralCrossRefGoogle Scholar
  286. 286.
    Landis SH, El-Hariry IA, van Herk-Sukel MP, van den Haak P, Janssen-Heijnen ML, Penning-van Beest FJ, et al. Prevalence and incidence of acute and chronic comorbidity in patients with squamous cell carcinoma of the head and neck. Head Neck. 2012;34(2):238–44.PubMedCrossRefGoogle Scholar
  287. 287.
    Wu CH, Wu TY, Li CC, Lui MT, Chang KW, Kao SY. Impact of diabetes mellitus on the prognosis of patients with oral squamous cell carcinoma: a retrospective cohort study. Ann Surg Oncol. 2010;17(8):2175–83.PubMedCrossRefGoogle Scholar
  288. 288.
    Surveillance E, and End Results (SEER) Program (www.seer.cancer.gov) SEER*Stat Database: Mortality – All COD, Aggregated With State, Total U.S. (1969–2012) < Katrina/Rita Population Adjustment>, National Cancer Institute, DCCPS, Surveillance Research Program, Surveillance Systems Branch, released April 2015. Underlying mortality data provided by NCHS (www.cdc.gov/nchs).Google Scholar
  289. 289.
    Warnakulasuriya S, Johnson NW, van der Waal I. Nomenclature and classification of potentially malignant disorders of the oral mucosa. J Oral Pathol Med. 2007;36(10):575–80.PubMedCrossRefGoogle Scholar
  290. 290.
    Reichart PA, Philipsen HP. Oral erythroplakia – a review. Oral Oncol. 2005;41(6):551–61.PubMedCrossRefGoogle Scholar
  291. 291.
    Scully C, Paes de Almeida O, Bagan J, Diz Dios P, Mosqueda Taylor A. Oral medicine and pathology at a glance. Chichester: Wiley Blackwell; 2014.Google Scholar
  292. 292.
    Brouns E, Baart J, Karagozoglu K, Aartman I, Bloemena E, van der Waal I. Malignant transformation of oral leukoplakia in a well-defined cohort of 144 patients. Oral Dis. 2014;20(3):e19–24.PubMedCrossRefGoogle Scholar
  293. 293.
    Meisel P, Dau M, Sümnig W, Holtfreter B, Houshmand M, Nauck M, et al. Association between glycemia, serum lipoproteins, and the risk of oral leukoplakia: the population-based Study of Health in Pomerania (SHIP). Diabetes Care. 2010;33(6):1230–2.PubMedPubMedCentralCrossRefGoogle Scholar
  294. 294.
    Moore PA, Guggenheimer J, Orchard T. Burning mouth syndrome and peripheral neuropathy in patients with type 1 diabetes mellitus. J Diabet Complications. 2007;21(6):397–402.CrossRefGoogle Scholar
  295. 295.
    Gibson J, Lamey PJ, Lewis M, Frier B. Oral manifestations of previously undiagnosed non-insulin dependent diabetes mellitus. J Oral Pathol Med. 1990;19(6):284–7.PubMedCrossRefGoogle Scholar
  296. 296.
    Arap A, Siqueira SR, Silva CB, Teixeira MJ, Siqueira JT. Trigeminal pain and quantitative sensory testing in painful peripheral diabetic neuropathy. Arch Oral Biol. 2010;55(7):486–93.PubMedCrossRefGoogle Scholar
  297. 297.
    Collin HL, Niskanen L, Uusitupa M, Töyry J, Collin P, Koivisto AM, et al. Oral symptoms and signs in elderly patients with type 2 diabetes mellitus. A focus on diabetic neuropathy. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2000;90(3):299–305.PubMedCrossRefGoogle Scholar
  298. 298.
    Scala A, Checchi L, Montevecchi M, Marini I, Giamberardino MA. Update on burning mouth syndrome: overview and patient management. Crit Rev Oral Biol Med. 2003;14(4):275–91.PubMedCrossRefGoogle Scholar
  299. 299.
    Grushka M. Clinical features of burning mouth syndrome. Oral Surg Oral Med Oral Pathol. 1987;63(1):30–6.PubMedCrossRefGoogle Scholar
  300. 300.
    Yilmaz Z, Renton T, Yiangou Y, Zakrzewska J, Chessell IP, Bountra C, et al. Burning mouth syndrome as a trigeminal small fibre neuropathy: increased heat and capsaicin receptor TRPV1 in nerve fibres correlates with pain score. J Clin Neurosci. 2007;14(9):864–71.PubMedCrossRefGoogle Scholar
  301. 301.
    Jääskeläinen SK. Pathophysiology of primary burning mouth syndrome. Clin Neurophysiol. 2012;123(1):71–7.PubMedCrossRefGoogle Scholar
  302. 302.
    Lauria G, Majorana A, Borgna M, Lombardi R, Penza P, Padovani A, et al. Trigeminal small-fiber sensory neuropathy causes burning mouth syndrome. Pain. 2005;115(3):332–7.PubMedCrossRefGoogle Scholar
  303. 303.
    Carrington J, Getter L, Brown RS. Diabetic neuropathy masquerading as glossodynia. J Am Dent Assoc. 2001;132(11):1549–51.PubMedCrossRefGoogle Scholar
  304. 304.
    Dersh J, Polatin PB, Gatchel RJ. Chronic pain and psychopathology: research findings and theoretical considerations. Psychosom Med. 2002;64(5):773–86.PubMedGoogle Scholar
  305. 305.
    Zakrzewska JM. Multi-dimensionality of chronic pain of the oral cavity and face. J Headache Pain. 2013;14:37.PubMedPubMedCentralCrossRefGoogle Scholar
  306. 306.
    Patton LL, Siegel MA, Benoliel R, De Laat A. Management of burning mouth syndrome: systematic review and management recommendations. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2007;103(Suppl):S39.e1–13.Google Scholar
  307. 307.
    Lamey PJ, Freeman R, Eddie SA, Pankhurst C, Rees T. Vulnerability and presenting symptoms in burning mouth syndrome. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2005;99(1):48–54.PubMedCrossRefGoogle Scholar
  308. 308.
    Carlson CR, Miller CS, Reid KI. Psychosocial profiles of patients with burning mouth syndrome. J Orofac Pain. 2000;14(1):59–64.PubMedGoogle Scholar
  309. 309.
    Ali S, Stone MA, Peters JL, Davies MJ, Khunti K. The prevalence of co-morbid depression in adults with type 2 diabetes: a systematic review and meta-analysis. Diabet Med. 2006;23(11):1165–73.PubMedCrossRefGoogle Scholar
  310. 310.
    Gendelman N, Snell-Bergeon JK, McFann K, Kinney G, Paul Wadwa R, Bishop F, et al. Prevalence and correlates of depression in individuals with and without type 1 diabetes. Diabetes Care. 2009;32(4):575–9.PubMedPubMedCentralCrossRefGoogle Scholar
  311. 311.
    Zakrzewska JM, Forssell H, Glenny AM. Interventions for the treatment of burning mouth syndrome. Cochrane Database Syst Rev. 2005; CD002779.Google Scholar
  312. 312.
    Sumlin LL, Garcia TJ, Brown SA, Winter MA, García AA, Brown A, et al. Depression and adherence to lifestyle changes in type 2 diabetes: a systematic review. Diabetes Educ. 2014;40(6):731–44.PubMedCrossRefGoogle Scholar
  313. 313.
    Moussavi S, Chatterji S, Verdes E, Tandon A, Patel V, Ustun B. Depression, chronic diseases, and decrements in health: results from the World Health Surveys. Lancet. 2007;370(9590):851–8.PubMedCrossRefGoogle Scholar
  314. 314.
    Lin EH, Von Korff M, Alonso J, Angermeyer MC, Anthony J, Bromet E, et al. Mental disorders among persons with diabetes – results from the World Mental Health Surveys. J Psychosom Res. 2008;65(6):571–80.PubMedPubMedCentralCrossRefGoogle Scholar
  315. 315.
    Harris MD. Psychosocial aspects of diabetes with an emphasis on depression. Curr Diab Rep. 2003;3(1):49–55.PubMedCrossRefGoogle Scholar
  316. 316.
    Smith KJ, Pedneault M, Schmitz N. Investigation of anxiety and depression symptom co-morbidity in a community sample with type 2 diabetes: associations with indicators of self-care. Can J Public Health. 2016;106(8):e496–501.PubMedGoogle Scholar
  317. 317.
    Sreebny LM, Schwartz SS. A reference guide to drugs and dry mouth – 2nd edition. Gerodontology. 1997;14(1):33–47.PubMedCrossRefGoogle Scholar
  318. 318.
    Spangler JG, Konen JC, McGann KP. Prevalence and predictors of problem drinking among primary care diabetic patients. J Fam Pract. 1993;37(4):370–5.PubMedGoogle Scholar
  319. 319.
    Engler PA, Ramsey SE, Smith RJ. Alcohol use of diabetes patients: the need for assessment and intervention. Acta Diabetol. 2013;50(2):93–9.PubMedCrossRefGoogle Scholar
  320. 320.
    Chew LD, Nelson KM, Young BA, Bradley KA. Association between alcohol consumption and diabetes preventive practices. Fam Med. 2005;37(8):589–94.PubMedGoogle Scholar
  321. 321.
    Mealey B. Management of the patient with diabetes mellitus in the dental office. In: Lamster I, editor. Diabetes mellitus and oral health: an interprofessional approach. Ames: Wiley Blackwell; 2014. p. 101–4.Google Scholar
  322. 322.
    Ueta E, Osaki T, Yoneda K, Yamamoto T. Prevalence of diabetes mellitus in odontogenic infections and oral candidiasis: an analysis of neutrophil suppression. J Oral Pathol Med. 1993;22(4):168–74.PubMedCrossRefGoogle Scholar
  323. 323.
    Lalla E, Kunzel C, Burkett S, Cheng B, Lamster IB. Identification of unrecognized diabetes and pre-diabetes in a dental setting. J Dent Res. 2011;90(7):855–60.PubMedCrossRefGoogle Scholar
  324. 324.
    Nasseh K, Vujicic M, Glick M. The relationship between periodontal interventions and healthcare costs and utilization. Evidence from an integrated dental, medical, and pharmacy commercial claims database. Health Econ. 2016. doi:10.1002/hec.3316. [Epub ahead of print]. PMID: 26799518.Google Scholar
  325. 325.
    Jeffcoat MK, Jeffcoat RL, Gladowski PA, Bramson JB, Blum JJ. Impact of periodontal therapy on general health: evidence from insurance data for five systemic conditions. Am J Prev Med. 2014;47(2):166–74.PubMedCrossRefGoogle Scholar
  326. 326.
    Mosen DM, Pihlstrom DJ, Snyder JJ, Shuster E. Assessing the association between receipt of dental care, diabetes control measures and health care utilization. J Am Dent Assoc. 2012;143(1):20–30.PubMedCrossRefGoogle Scholar
  327. 327.
    Cefalu W. American Diabetes Association: standards of medical care in diabetes. J Clin Appl Res Educ. 2015;38:S1–93. http://www.diabetes.teithe.gr/UsersFiles/entypa/STANDARDS%20OF%20MEDICAL%20CARE%20IN%20DIABETES%202015.pdf
  328. 328.
    PI E, GO T-E, GL B. Dental visits among dentate adults with diabetes – United States, 1999 and 2004. 2005. Report No.: Contract No.: 46.Google Scholar
  329. 329.
    Macek MD, Taylor GW, Tomar SL. Dental care visits among dentate adults with diabetes, United States, 2003. J Public Health Dent. 2008;68(2):102–10.PubMedCrossRefGoogle Scholar
  330. 330.
    Moore PA, Orchard T, Guggenheimer J, Weyant RJ. Diabetes and oral health promotion: a survey of disease prevention behaviors. J Am Dent Assoc. 2000;131(9):1333–41.PubMedCrossRefGoogle Scholar
  331. 331.
    Chaudhari M, Hubbard R, Reid RJ, Inge R, Newton KM, Spangler L, et al. Evaluating components of dental care utilization among adults with diabetes and matched controls via hurdle models. BMC Oral Health. 2012;12:20.PubMedPubMedCentralCrossRefGoogle Scholar
  332. 332.
    Azogui-Lévy S, Dray-Spira R. Sociodemographic factors associated with the dental health of persons with diabetes in France. Spec Care Dentist. 2012;32(4):142–9.PubMedCrossRefGoogle Scholar
  333. 333.
    Berwick DM, Nolan TW, Whittington J. The triple aim: care, health, and cost. Health Affairs. 2008;27(3):759–69.Google Scholar
  334. 334.
    Hummel J, Phillips KE, Holt B, Hayes C. Oral health: an essential component of primary care. Seattle: Qualis Health; 2015.Google Scholar
  335. 335.
    Lalla E, Lamster IB. Assessment and management of patients with diabetes mellitus in the dental office. Dent Clin North Am. 2012;56(4):819–29.PubMedCrossRefGoogle Scholar
  336. 336.
    Elangovan S, Hertzman-Miller R, Karimbux N, Giddon D. A framework for physician-dentist collaboration in diabetes and periodontitis. Clin Diabetes. 2014;32(4):188–92.PubMedPubMedCentralCrossRefGoogle Scholar

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© Springer International Publishing Switzerland (outside the USA) 2017

Authors and Affiliations

  1. 1.Department of Oral MedicineUniversity of Washington School of DentistrySeattleUSA

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