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Syndromes of Extreme Insulin Resistance

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Principles of Diabetes Mellitus

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Abstract

This group of syndromes shares severe insulin resistance and hyperinsulinemia with variable clinical manifestations (Kahn et al., N Engl J Med 294:739–745, 1976; Moller and Flier, N Engl J Med 325:938–948, 1991). Attention has been paid to these rare disorders because they provide insight into several aspects of insulin action at the molecular level and advance our understanding of the more common insulin-resistant disorders, such as polycystic ovarian syndrome (Barbieri et al., Fertil Steril 50:197–202, 1988) and type 2 diabetes mellitus (Barroso et al., Nature 402:880–883, 1999).

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Authors and Affiliations

  1. Internal Medicine and Molecular Medicine and Genetics, Grunberger Diabetes Institute, Wayne State University School of Medicine, Bloomfield Hills, MI, USA

    George Grunberger

  2. Grunberger Diabetes Institute, Bloomfield Hills, MI, USA

    Anjana Myneni

  3. Coral Gables, FL, USA

    Bianca Alfonso

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  1. George Grunberger
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  2. Anjana Myneni
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Correspondence to George Grunberger .

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Editors and Affiliations

  1. Division of Endocrinology, Gerald J. Friedman Diabetes Institute, Lenox Hill Hospital, Hofstra Northwell School of Medicine, Northwell Health, New York, New York, USA

    Leonid Poretsky

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Grunberger, G., Myneni, A., Alfonso, B. (2017). Syndromes of Extreme Insulin Resistance. In: Poretsky, L. (eds) Principles of Diabetes Mellitus. Springer, Cham. https://doi.org/10.1007/978-3-319-18741-9_17

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