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Physiology and Abnormalities of Leukocytes in Newborns

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Abstract

The circulating pool of neutrophils reflect a dynamic equilibrium between pools of neutrophil precursors and mature neutrophils in the bone marrow, circulating neutrophils, and activated neutrophils that have emigrated into the tissues. The bone marrow is the predominant hematopoietic organ after birth. Within the bone marrow, pluripotential hematopoietic stem and progenitor cells give rise to lineage committed neutrophil precursors. These precursors mature under the influence of growth factors such as granulocyte colony-stimulating factor (G-CSF) and granulocyte-macrophage colony-stimulating factor (GM-CSF). The bone marrow thus contains pools of immature neutrophils and of stored mature neutrophils. After emigration from the bone marrow, neutrophils enter the circulation for a brief period of hours then translocate into the tissues.

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Authors and Affiliations

  1. Perinatal Institute, Cincinnati Children’s Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH, 45229, USA

    Kurt R. Schibler

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  1. Kurt R. Schibler
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Correspondence to Kurt R. Schibler .

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  1. Siena, Italy

    Giuseppe Buonocore

  2. Medicina della Riproduzione, Università di Siena Dipto. Pediatria, Ostetricia e, Siena, Italy

    Rodolfo Bracci

  3. Liverpool Women's Hospital Neonatal Unit, Liverpool, United Kingdom

    Michael Weindling

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Schibler, K.R. (2016). Physiology and Abnormalities of Leukocytes in Newborns. In: Buonocore, G., Bracci, R., Weindling, M. (eds) Neonatology. Springer, Cham. https://doi.org/10.1007/978-3-319-18159-2_243-1

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  • DOI: https://doi.org/10.1007/978-3-319-18159-2_243-1

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  • Publisher Name: Springer, Cham

  • Online ISBN: 978-3-319-18159-2

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