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Benign Vulvar and Vaginal Pathology

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  • First Online:
Handbook of Gynecology

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Abstract

Vulvar and vaginal lesions may include benign, premalignant, and malignant neoplasms. Identifying normal variants, benign findings, and possibly serious diseases is a challenge for a clinician. Skin disorders of the vulva include a wide range of conditions characterized by inflammation and affecting the extragenital region as well. Sexual function and overall sense of well-being can be adversely affected by vulvovaginal symptoms that can be chronic.

This chapter provides updated diagnostic and management recommendations regarding the most common benign vaginal and vulvar pathologies.

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References

  • American College of O, Gynecologists’ Committee on Practice B-G. Diagnosis and management of vulvar skin disorders: ACOG practice bulletin, number 224. Obstet Gynecol 2020;136(1):e1-e14.

    Google Scholar 

  • Brenn T. Atypical genital nevus. Arch Pathol Lab Med. 2011;135(3):317–20.

    Article  Google Scholar 

  • Byrd JA, Davis MD, Rogers RS 3rd. Recalcitrant symptomatic vulvar lichen planus: response to topical tacrolimus. Arch Dermatol. 2004;140(6):715–20.

    Article  Google Scholar 

  • Cengiz FP, Emiroglu N, Wellenhof RH. Dermoscopic and clinical features of pigmented skin lesions of the genital area. An Bras Dermatol. 2015;90(2):178–83.

    Article  Google Scholar 

  • Cheng H, Oakley A, Rowan D, Lamont D. Diagnostic criteria in 72 women with erosive vulvovaginal lichen planus. Australas J Dermatol. 2016;57(4):284–7.

    Article  Google Scholar 

  • Chibnall R. Vulvar pruritus and lichen simplex chronicus. Obstet Gynecol Clin N Am. 2017;44(3):379–88.

    Article  Google Scholar 

  • Chiesa-Vottero A, Dvoretsky PM, Hart WR. Histopathologic study of thin vulvar squamous cell carcinomas and associated cutaneous lesions: a correlative study of 48 tumors in 44 patients with analysis of adjacent vulvar intraepithelial neoplasia types and lichen sclerosus. Am J Surg Pathol. 2006;30(3):310–8.

    Article  Google Scholar 

  • Cooper SM, Wojnarowska F. Influence of treatment of erosive lichen planus of the vulva on its prognosis. Arch Dermatol. 2006;142(3):289–94.

    Article  Google Scholar 

  • Cooper SM, Ali I, Baldo M, Wojnarowska F. The association of lichen sclerosus and erosive lichen planus of the vulva with autoimmune disease: a case-control study. Arch Dermatol. 2008;144(11):1432–5.

    Article  Google Scholar 

  • Dalziel KL. Effect of lichen sclerosus on sexual function and parturition. J Reprod Med. 1995;40(5):351–4.

    CAS  Google Scholar 

  • Dasgupta S, van Eersel R, Morrel B, van den Munckhof HAM, de Geus VA, van der Hoeven NMA, et al. Relationship of human papillomavirus with seborrheic keratosis of the female genital tract – a case-series and literature review. Histol Histopathol. 2021:18357.

    Google Scholar 

  • Duhan N, Kalra R, Singh S, Rajotia N. Hidradenoma papilliferum of the vulva: case report and review of literature. Arch Gynecol Obstet. 2011;284(4):1015–7.

    Article  Google Scholar 

  • Eisendle K, Grabner T, Kutzner H, Zelger B. Possible role of Borrelia burgdorferi sensu lato infection in lichen sclerosus. Arch Dermatol. 2008;144(5):591–8.

    Article  Google Scholar 

  • Gautam MM, Singh V, Nadkarni NJ, Patil SP. Anogenital lichen sclerosus. Indian J Sex Transm Dis AIDS. 2020;41(1):1–9.

    Article  Google Scholar 

  • Jih DM, Elder DE, Elenitsas R. A histopathologic evaluation of vulvar melanosis. Arch Dermatol. 1999;135(7):857–8.

    Article  CAS  Google Scholar 

  • Kondi-Pafiti A, Grapsa D, Papakonstantinou K, Kairi-Vassilatou E, Xasiakos D. Vaginal cysts: a common pathologic entity revisited. Clin Exp Obstet Gynecol. 2008;35(1):41–4.

    CAS  Google Scholar 

  • Lewis FM, Shah M, Harrington CI. Vulval involvement in lichen planus: a study of 37 women. Br J Dermatol. 1996;135(1):89–91.

    Article  CAS  Google Scholar 

  • Lynch PJ, Moyal-Barracco M, Scurry J, Stockdale C. 2011 ISSVD Terminology and classification of vulvar dermatological disorders: an approach to clinical diagnosis. J Low Genit Tract Dis. 2012;16(4):339–44.

    Article  Google Scholar 

  • Madueke-Laveaux OS, Gogoi R, Stoner G. Giant fibroepithelial stromal polyp of the vulva: largest case reported. Ann Surg Innov Res. 2013;7:8.

    Article  Google Scholar 

  • Murzaku EC, Penn LA, Hale CS, Pomeranz MK, Polsky D. Vulvar nevi, melanosis, and melanoma: an epidemiologic, clinical, and histopathologic review. J Am Acad Dermatol. 2014;71(6):1241–9.

    Article  Google Scholar 

  • Navada MH, Bhat PR, Rao SV, Nagarathna G. Large fibroepithelial polyp of vulva. Case Rep Dermatol Med. 2011;2011:273181.

    Google Scholar 

  • Nelson DM, Peterson AC. Lichen sclerosus: epidemiological distribution in an equal access health care system. J Urol. 2011;185(2):522–5.

    Article  Google Scholar 

  • Nucci MR, Young RH, Fletcher CD. Cellular pseudosarcomatous fibroepithelial stromal polyps of the lower female genital tract: an underrecognized lesion often misdiagnosed as sarcoma. Am J Surg Pathol. 2000;24(2):231–40.

    Article  CAS  Google Scholar 

  • Pugliese JM, Morey AF, Peterson AC. Lichen sclerosus: review of the literature and current recommendations for management. J Urol. 2007;178(6):2268–76.

    Article  Google Scholar 

  • Quaresma C, Sparzak PB. Anatomy, abdomen and pelvis, Bartholin gland. Treasure Island: StatPearls; 2021.

    Google Scholar 

  • Ribe A. Melanocytic lesions of the genital area with attention given to atypical genital nevi. J Cutan Pathol. 2008;35(Suppl 2):24–7.

    Article  Google Scholar 

  • Scurry J, van der Putte SC, Pyman J, Chetty N, Szabo R. Mammary-like gland adenoma of the vulva: review of 46 cases. Pathology. 2009;41(4):372–8.

    Article  Google Scholar 

  • Stamm AW, Kobashi KC, Stefanovic KB. Urologic dermatology: a review. Curr Urol Rep. 2017;18(8):62.

    Article  Google Scholar 

  • Vazmitel M, Spagnolo DV, Nemcova J, Michal M, Kazakov DV. Hidradenoma papilliferum with a ductal carcinoma in situ component: case report and review of the literature. Am J Dermatopathol. 2008;30(4):392–4.

    Article  Google Scholar 

  • Virgili A, Borghi A, Toni G, Minghetti S, Corazza M. Prospective clinical and epidemiologic study of vulvar lichen sclerosus: analysis of prevalence and severity of clinical features, together with historical and demographic associations. Dermatology. 2014;228(2):145–51.

    Article  Google Scholar 

  • Wang DG, Huang FR, Chen W, Zhou Y, Wang CY, Zhu F, et al. Clinicopathological analysis of acquired melanocytic nevi and a preliminary study on the possible origin of nevus cells. Am J Dermatopathol. 2020;42(6):414–22.

    Article  Google Scholar 

  • Weyers W. Hypertrophic lichen sclerosus with dyskeratosis and parakeratosis--a common presentation of vulvar lichen sclerosus not associated with a significant risk of malignancy. Am J Dermatopathol. 2013;35(7):713–21.

    Article  Google Scholar 

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Author information

Authors and Affiliations

  1. Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA

    Pouya Javadian

  2. Laboratory Medicine Consultants, Las Vegas, NV, USA

    Daman Samrao

  3. Division of Gynecologic Oncology, Department of Obstetrics, Gynecology and Reproductive Sciences, Loma Linda University Medical Center, Loma Linda, CA, USA

    Mazdak Momeni

Authors
  1. Pouya Javadian
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  2. Daman Samrao
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  3. Mazdak Momeni
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Editor information

Editors and Affiliations

  1. Department of Obstetrics and Gynecology and Family Medicine, University of Southern California Keck School of Medicine, Los Angeles, CA, USA

    Donna Shoupe

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Javadian, P., Samrao, D., Momeni, M. (2023). Benign Vulvar and Vaginal Pathology. In: Shoupe, D. (eds) Handbook of Gynecology. Springer, Cham. https://doi.org/10.1007/978-3-319-17002-2_60-2

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  • DOI: https://doi.org/10.1007/978-3-319-17002-2_60-2

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-17002-2

  • Online ISBN: 978-3-319-17002-2

  • eBook Packages: Springer Reference MedicineReference Module Medicine

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