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Advanced Engineering Approaches in the Development of PLGA-Based Nanomedicines

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Handbook of Nanoparticles

Abstract

Drug molecules often display little affinity for nonhealthy tissues and/or cells, leading to inefficiency, and high incidence of severe side effects. To face the problem, numerous strategies have been postulated, i.e., chemical modifications to the drug molecule, and proper engineering of drug nanocarriers. In this line, the introduction of poly(d,l-lactide-co-glycolide) nanoparticles in the drug delivery arena has been hypothesized to optimize drug biodistribution and concentration into the targeted site, thus improving the therapeutic effect while reducing the associated drug toxicity. Recent advances in the field have been devoted to the optimization of the in vivo fate and effectiveness of poly(d,l-lactide-co-glycolide)-based drug nanocarriers, i.e., by passive targeting strategies based on the functionalization of the particle surface with special biomolecules, and/or active targeting stratagems thanks to modifications leading to stimuli-responsive nanoparticles. In this chapter, we analyze the current state of the art and future perspectives in the formulation of poly(d,l-lactide-co-glycolide)-based nanomedicines against severe diseases.

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Abbreviations

17-AAG:

17-Allylamino-17-demethoxygeldanamycin

AEMA:

2-Aminoethyl methacrylamide

ALE:

Alendronate

anti-DR5:

Anti-death receptor 5

anti-EGFR:

Anti-epidermal growth factor receptor

anti-EpCAM:

Anti-epithelial cell adhesion molecule

anti-HER2:

Anti-human epidermal growth factor receptor 2

APO-1:

Apoptosis antigen 1

Apt:

Aptamer

7α-APTADD:

7α-(4′-Amino)phenylthio-1,4-androstadiene-3,17-dione

BBB:

Blood-brain barrier

BP:

Bisphosphonate

bPEI:

Branched poly(ethyleneimine)

BSA:

Bovine serum albumin

cLABL:

cyclo(1,12)PenITDGEATDSGC

CLR:

C-type lectin receptor

CPP:

Cell-penetrating peptide

CPT:

Camptothecin

cRGD:

Cyclic arginine-glycine-aspartic acid

DC:

Dendritic cell

DNA:

Deoxyribonucleic acid

DOPE:

1,2-Dioleoyl-sn-glycero-3-phosphoethanolamine

DOSPA:

2,3-Dioleyloxy-N-[2(sperminecarboxamido)ethyl]-N,N-dimethyl-1-propanaminium trifluoroacetate

DOX:

Doxorubicin

DSPE:

1,2-Distearoyl-sn-glycero-3-phosphoethanolamine

DTPA:

Diethylenetriaminepentaacetic acid

EDC:

1-Ethyl-3-(3-dimethylaminopropyl)-carbodiimide

EPR:

Enhanced permeability and retention

FA:

Folic acid

FDA:

Food and Drug Administration

FR:

Far red

G-rich:

Guanosine-rich

gWiz-Luc:

Firefly luciferase reporter gene

HIV-1:

Human immunodeficiency virus type 1

HUVEC:

Human umbilical vein endothelial cell

IC50 :

Half maximum inhibitory concentration

ICAM-1:

Intercellular adhesion molecule-1

ICG:

Indocyanine green

KC:

Kupffer cell

MAb:

Monoclonal antibody

MAN:

Mannan

MDR1:

Multidrug resistance 1

Mw :

Molecular weight

Neu5Ac:

N-Acetylneuraminic acid

NHS:

N-Hydroxysucinimide

NIR:

Near infrared

NP:

Nanoparticle

OL:

Odorranalectin

OVA:

Ovalbumin

pDNA:

Plasmid deoxyribonucleic acid

PE:

l-α-Phosphatidylethanolamine

PEG:

Poly(ethylene glycol)

pEGFP:

Plasmid enhanced green fluorescent protein

PEI:

Poly(ethyleneimine)

P-gp:

P-glycoprotein

PLGA:

Poly(d,l-lactide-co-glycolide)

PSMA:

Prostate-specific membrane antigen

PTX:

Paclitaxel

PVA:

Polyvinyl alcohol

RES:

Reticuloendothelial system

RGD:

Arginine-glycine-aspartic acid

RNA:

Ribonucleic acid

SA:

Sialic acid

siRNA:

Small interfering ribonucleic acid

STL:

Solanum tuberosum lectin

TAT:

Transactivating transcriptional activator

Tf:

Transferrin

Tg:

Glass transition temperature

TNF:

Tumor necrosis factor

VCR:

Vincristine

WGA:

Wheat germ agglutinin

ζ:

Zeta potential

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Authors and Affiliations

  1. Department of Pharmacy and Pharmaceutical Technology, Faculty of Pharmacy, University of Granada, Campus Universitario de Cartuja s/n, 18071, Granada, Spain

    Mazen M. El-Hammadi & José L. Arias

  2. Department of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmacy, Damascus University, Damascus, Syria

    Mazen M. El-Hammadi

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  1. Mazen M. El-Hammadi
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  2. José L. Arias
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Correspondence to José L. Arias .

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  1. Department of Materials Engineering, Tarbiat Modares University, Tehran, Iran

    Mahmood Aliofkhazraei

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El-Hammadi, M.M., Arias, J.L. (2016). Advanced Engineering Approaches in the Development of PLGA-Based Nanomedicines. In: Aliofkhazraei, M. (eds) Handbook of Nanoparticles. Springer, Cham. https://doi.org/10.1007/978-3-319-15338-4_45

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