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Nanoparticles as Nonviral Transfection Agents

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Handbook of Nanoparticles

Abstract

A series of studies have been carried out for delivery and controlled release of genes, miRNAs, peptide structures, siRNAs, and pharmacological agents to the target tissues through different nanoparticles. Agents to be delivered are either attached on or entrapped in nanoparticle structure. In the delivery process, the nanocarriers face many different delivery tasks and different physiological microenvironments. Considering the changes in the environment, nanocarriers are designed and synthesized in such a manner that enables these structures to overcome the challenges faced during delivery. In this chapter nanoparticle structures as cationic lipids, polycationic polymers, and dendrimers used in drug and gene delivery are reviewed.

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Authors and Affiliations

  1. Science and Technology Application and Research Center, Yıldız Technical University, 34349, Istanbul, Turkey

    Nelisa Türkoğlu Laçin & Kadriye Kızılbey

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  1. Nelisa Türkoğlu Laçin
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  2. Kadriye Kızılbey
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Correspondence to Nelisa Türkoğlu Laçin .

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  1. Department of Materials Engineering, Tarbiat Modares University, Tehran, Iran

    Mahmood Aliofkhazraei

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Laçin, N.T., Kızılbey, K. (2016). Nanoparticles as Nonviral Transfection Agents. In: Aliofkhazraei, M. (eds) Handbook of Nanoparticles. Springer, Cham. https://doi.org/10.1007/978-3-319-15338-4_40

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