Abstract
Knee joint osteoarthritis (OA) is the most common condition that is managed with knee joint replacement surgery. Gait has provided a model to study knee OA processes as knee joint function is altered in the presence of knee OA including joint level angular motions, joint level moments, and muscle activation patterns during walking. In the pre-total joint arthroplasty state, there is significant joint damage and severe symptoms (pain) that manifest as altered musculoskeletal function during walking. These alterations in joint and muscle function during gait can be accurately quantified with state-of-the-art surface motion capture systems, force plates, biomechanical modeling, and surface electromyography to capture muscle activation patterns. This chapter provides an overview of the gait biomechanics and EMG studies related to (i) knee joint OA processes and (ii) knee joint replacement surgery. The summary and conclusions provide ideas on future directions suggesting that human movement studies need to be better integrated in clinical musculoskeletal practice to provide the quantitative measures of function that can inform clinical decision making.
References
Abdel MP, Parratte S, Blanc G, Ollivier M, Pomero V, Viehweger E, Argenson JN (2014) No benefit of patient-specific instrumentation in TKA on functional and gait outcomes: a randomized clinical trial. Clin Orthop Relat Res 472(8):2468–2476. https://doi.org/10.1007/s11999-014-3544-7
Alnahdi AH, Zeni JA, Snyder-Mackler L (2011) Gait after unilateral total knee arthroplasty: frontal plane analysis. J Orthop Res 29(5):647–652. https://doi.org/10.1002/jor.21323
Amin S, Luepongsak N, McGibbon CA, LaValley MP, Krebs DE, Felson DT (2004) Knee adduction moment and development of chronic knee pain in elders. Arthritis Care Res 51(3):371–376
Andriacchi TP, Mündermann A, Smith RL, Alexander EJ, Dyrby CO, Koo S (2004) A framework for the in vivo pathomechanics of osteoarthritis at the knee. Ann Biomed Eng 32(3):447–457. https://doi.org/10.1023/B:ABME.0000017541.82498.37
Andriacchi TP, Ogle JA, Galante JO (1977) Walking speed as a basis for normal and abnormal gait measurements. J Biomech 10(4):261–268
Astephen JL, Deluzio KJ, Caldwell GE, Dunbar MJ (2008a) Biomechanical changes at the hip, knee, and ankle joints during gait are associated with knee osteoarthritis severity. J Orthop Res 26(3):332–341. https://doi.org/10.1002/jor.20496
Astephen JL, Deluzio KJ, Caldwell GE, Dunbar MJ, Hubley-Kozey CL (2008b) Gait and neuromuscular pattern changes are associated with differences in knee osteoarthritis severity levels. J Biomech 41(4):868–876. https://doi.org/10.1016/j.jbiomech.2007.10.016
Astephen Wilson JL (2012) Challenges in dealing with walking speed in knee osteoarthritis gait analyses. Clin Biomech 27(3):210–212. https://doi.org/10.1016/j.clinbiomech.2011.09.009
Astephen Wilson JL, Deluzio KJ, Dunbar MJ, Caldwell GE, Hubley-Kozey CL (2011) The association between knee joint biomechanics and neuromuscular control and moderate knee osteoarthritis radiographic and pain severity. Osteoarthr Cartil 19(2):186–193. https://doi.org/10.1016/j.joca.2010.10.020
Astephen Wilson JL, Dunbar MJ, Hubley-Kozey CL (2015) Knee joint biomechanics and neuromuscular control during gait before and after total knee arthroplasty are sex-specific. J Arthroplast 30(1):118–125. https://doi.org/10.1016/j.arth.2014.07.028
Astephen Wilson JL, Stanish WD, Hubley-Kozey CL (2016) Asymptomatic and symptomatic individuals with the same radiographic evidence of knee osteoarthritis walk with different knee moments and muscle activity. J Orthop Res. https://doi.org/10.1002/jor.23465
Astephen Wilson JL, Wilson DA, Dunbar MJ, Deluzio KJ (2010) Preoperative gait patterns and BMI are associated with tibial component migration. Acta Orthop 81(4):478–486. https://doi.org/10.3109/17453674.2010.501741
Baliunas AJ, Hurwitz DE, Ryals AB, Karrar A, Case JP, Block JA, Andriacchi TP (2002) Increased knee joint loads during walking are present in subjects with knee osteoarthritis. Osteoarthr Cartil 10(7):573–579. https://doi.org/10.1053/joca.2002.0797
Barker K, Lamb SE, Toye F, Jackson S, Barrington S (2004) Association between radiographic joint space narrowing, function, pain and muscle power in severe osteoarthritis of the knee. Clin Rehabil 18(7):793–800
Benedetti MG, Catani F, Bilotta TW, Marcacci M, Mariani E, Giannini S (2003) Muscle activation pattern and gait biomechanics after total knee replacement. Clin Biomech 18(9):871–876. https://doi.org/10.1016/s0268-0033(03)00146-3
Bennell KL, Bowles KA, Wang Y, Cicuttini F, Davies-Tuck M, Hinman RS (2011) Higher dynamic medial knee load predicts greater cartilage loss over 12 months in medial knee osteoarthritis. Ann Rheum Dis 70(10):1770–1774. https://doi.org/10.1136/ard.2010.147082
Birmingham TB, Hunt MA, Jones IC, Jenkyn TR, Giffin JR (2007) Test-retest reliability of the peak knee adduction moment during walking in patients with medial compartment knee osteoarthritis. Arthritis Rheum 57(6):1012–1017. https://doi.org/10.1002/art.22899
Bourne RB, Chesworth BM, Davis AM, Mahomed NN, Charron KD (2010) Patient satisfaction after total knee arthroplasty: who is satisfied and who is not? Clin Orthop Relat Res 468(1):57–63. https://doi.org/10.1007/s11999-009-1119-9
Brandon SCE, Graham RB, Almosnino S, Sadler EM, Stevenson JM, Deluzio KJ (2013) Interpreting principal components in biomechanics: representative extremes and single component reconstruction. J Electromyogr Kinesiol 23(6):1304–1310. https://doi.org/10.1016/j.jelekin.2013.09.010
Brandt KD, Radin EL, Dieppe PA, Van De Putte L (2006) Yet more evidence that osteoarthritis is not a cartilage disease. Ann Rheum Dis 65(10):1261–1264. https://doi.org/10.1136/ard.2006.058347
Chang AH, Moisio KC, Chmiel JS, Eckstein F, Guermazi A, Prasad PV, Zhang Y, Almagor O, Belisle L, Hayes K, Sharma L (2015) External knee adduction and flexion moments during gait and medial tibiofemoral disease progression in knee osteoarthritis. Osteoarthr Cartil. https://doi.org/10.1016/j.joca.2015.02.005
Chehab EF, Favre J, Erhart-Hledik JC, Andriacchi TP (2014) Baseline knee adduction and flexion moments during walking are both associated with 5year cartilage changes in patients with medial knee osteoarthritis. Osteoarthr Cartil 22(11):1833–1839. https://doi.org/10.1016/j.joca.2014.08.009
Childs JD, Sparto PJ, Fitzgerald GK, Bizzini M, Irrgang JJ (2004) Alterations in lower extremity movement and muscle activation patterns in individuals with knee osteoarthritis. Clin Biomech (Bristol, Avon) 19(1):44–49. S0268003303002006 [pii]
Deluzio KJ, Astephen JL (2007) Biomechanical features of gait waveform data associated with knee osteoarthritis. An application of principal component analysis. Gait Posture 25(1):86–93. https://doi.org/10.1016/j.gaitpost.2006.01.007
Federolf PA, Boyer KA, Andriacchi TP (2013) Application of principal component analysis in clinical gait research: identification of systematic differences between healthy and medial knee-osteoarthritic gait. J Biomech 46(13):2173–2178. https://doi.org/10.1016/j.jbiomech.2013.06.032
Franklin PD, Li W, Ayers DC (2008) The Chitranjan Ranawat award: functional outcome after total knee replacement varies with patient attributes. Clin Orthop Relat Res 466(11):2597–2604. https://doi.org/10.1007/s11999-008-0428-8
Gossec L, Paternotte S, Bingham Iii CO, Clegg DO, Coste P, Conaghan PG, Davis AM, Giacovelli G, Gunther KP, Hawker G, Hochberg MC, Jordan JM, Katz JN, Kloppenburg M, Lanzarotti A, Lim K, Lohmander LS, Mahomed NN, Maillefert JF, Manno RL, March LM, Mazzuca SA, Pavelka K, Punzi L, Roos EM, Rovati LC, Shi H, Singh JA, Suarez-Almazor ME, Tajana-Messi E, Dougados M (2011) OARSI/OMERACT initiative to define states of severity and indication for joint replacement in hip and knee osteoarthritis. An OMERACT 10 special interest group. J Rheumatol 38(8):1765–1769. https://doi.org/10.3899/jrheum.110403
Hatfield GL, Hubley-Kozey CL, Astephen Wilson JL, Dunbar MJ (2011) The effect of total knee arthroplasty on knee joint kinematics and kinetics during gait. J Arthroplast 26(2):309–318. https://doi.org/10.1016/j.arth.2010.03.021. S0883-5403(10)00216-0 [pii]
Hatfield GL, Stanish WD, Hubley-Kozey CL (2015a) Relationship between knee adduction moment patterns extracted using principal component analysis and discrete measures with different amplitude normalizations: implications for knee osteoarthritis progression studies. Clin Biomech (Bristol, Avon) 30(10):1146–1152. https://doi.org/10.1016/j.clinbiomech.2015.08.011
Hatfield GL, Stanish WD, Hubley-Kozey CL (2015b) Three-dimensional biomechanical gait characteristics at baseline are associated with progression to total knee arthroplasty. Arthritis Care Res. https://doi.org/10.1002/acr.22564
Henriksen M, Alkjaer T, Lund H, Simonsen EB, Graven-Nielsen T, Danneskiold-Samsoe B, Bliddal H (2007) Experimental quadriceps muscle pain impairs knee joint control during walking. J Appl Physiol (1985) 103(1):132–139. https://doi.org/10.1152/japplphysiol.01105.2006
Henriksen M, Simonsen EB, Alkjaer T, Lund H, Graven-Nielsen T, Danneskiold-Samsoe B, Bliddal H (2006) Increased joint loads during walking – a consequence of pain relief in knee osteoarthritis. Knee 13(6):445–450. https://doi.org/10.1016/j.knee.2006.08.005
Hilding MB, Lanshammar H, Ryd L (1996) Knee joint loading and tibial component loosening. RSA and gait analysis in 45 osteoarthritic patients before and after TKA. J Bone Joint Surg Br 78(1):66–73
Hilding MB, Ryd L, Toksvig-Larsen S, Mann A, Stenstrom A (1999) Gait affects tibial component fixation. J Arthroplast 14(5):589–593
Hubley-Kozey CL, Deluzio KJ, Landry SC, McNutt JS, Stanish WD (2006) Neuromuscular alterations during walking in persons with moderate knee osteoarthritis. J Electromyogr Kinesiol 16(4):365–378. https://doi.org/10.1016/j.jelekin.2005.07.014
Hubley-Kozey CL, Hatfield GL, Astephen Wilson JL, Dunbar MJ (2010) Alterations in neuromuscular patterns between pre and one-year post-total knee arthroplasty. Clin Biomech (Bristol, Avon) 25(10):995–1002. https://doi.org/10.1016/j.clinbiomech.2010.07.008. S0268-0033(10)00201-9 [pii]
Hubley-Kozey CL, Hill NA, Rutherford DJ, Dunbar MJ, Stanish WD (2009) Co-activation differences in lower limb muscles between asymptomatic controls and those with varying degrees of knee osteoarthritis during walking. ClinBiomech(Bristol, Avon) 24(5):407–414. https://doi.org/10.1016/j.clinbiomech.2009.02.005. S0268-0033(09)00045-X [pii]
Hubley-Kozey CL, Robbins SM, Rutherford DJ, Stanish WD (2013) Reliability of surface electromyographic recordings during walking in individuals with knee osteoarthritis. J Electromyogr Kinesiol 23(2):334–341. https://doi.org/10.1016/j.jelekin.2012.12.002
Hurwitz DE, Ryals AB, Case JP, Block JA, Andriacchi TP (2002) The knee adduction moment during gait in subjects with knee osteoarthritis is more closely correlated with static alignment than radiographic disease severity, toe out angle and pain. J Orthop Res 20(1):101–107. https://doi.org/10.1016/S0736-0266(01)00081-X
Kaufman KR, Hughes C, Morrey BF, Morrey M, An KN (2001) Gait characteristics of patients with knee osteoarthritis. J Biomech 34(7):907–915
Kellgren JH, Lawrence JS (1957) Radiological assessment of osteo-arthrosis. Ann Rheum Dis 16(4):494–502
Landry SC, McKean KA, Hubley-Kozey CL, Stanish WD, Deluzio KJ (2007) Knee biomechanics of moderate OA patients measured during gait at a self-selected and fast walking speed. J Biomech 40(8):1754–1761. https://doi.org/10.1016/j.jbiomech.2006.08.010
Lewek MD, Rudolph KS, Snyder-Mackler L (2004) Control of frontal plane knee laxity during gait in patients with medial compartment knee osteoarthritis. Osteoarthr Cartil 12(9):745–751. https://doi.org/10.1016/j.joca.2004.05.005
Maly MR (2008) Abnormal and cumulative loading in knee osteoarthritis. Curr Opin Rheumatol 20(5):547–552. https://doi.org/10.1097/BOR.0b013e328307f58c
Manal K, Gardinier E, Buchanan TS, Snyder-Mackler L (2015) A more informed evaluation of medial compartment loading: the combined use of the knee adduction and flexor moments. Osteoarthr Cartil 23(7):1107–1111. https://doi.org/10.1016/j.joca.2015.02.779
Mandeville D, Osternig LR, Lantz BA, Mohler CG, Chou LS (2008) The effect of total knee replacement on the knee varus angle and moment during walking and stair ascent. Clin Biomech (Bristol, Avon) 23(8):1053–1058. https://doi.org/10.1016/j.clinbiomech.2008.04.011
McKean KA, Landry SC, Hubley-Kozey CL, Dunbar MJ, Stanish WD, Deluzio KJ (2007) Gender differences exist in osteoarthritic gait. Clin Biomech 22(4):400–409. https://doi.org/10.1016/j.clinbiomech.2006.11.006
Miyazaki T, Wada M, Kawahara H, Sato M, Baba H, Shimada S (2002) Dynamic load at baseline can predict radiographic disease progression in medial compartment knee osteoarthritis. Ann Rheum Dis 61(7):617–622. https://doi.org/10.1136/ard.61.7.617
Mundermann A, Dyrby CO, Hurwitz DE, Sharma L, Andriacchi TP (2004) Potential strategies to reduce medial compartment loading in patients with knee osteoarthritis of varying severity: reduced walking speed. Arthritis Rheum 50(4):1172–1178. https://doi.org/10.1002/art.20132
Orishimo KF, Kremenic IJ, Deshmukh AJ, Nicholas SJ, Rodriguez JA (2012) Does total knee arthroplasty change frontal plane knee biomechanics during gait? Clin Orthop Relat Res 470(4):1171–1176. https://doi.org/10.1007/s11999-011-2196-0
Piazza S, Cavanaugh P (2000) Measurement of the screw-home motion of the knee sensitive to errors in axis alignment. J Biomech 33:1029–1034
Robbins SM, Astephen Wilson JL, Rutherford DJ, Hubley-Kozey CL (2013) Reliability of principal components and discrete parameters of knee angle and moment gait waveforms in individuals with moderate knee osteoarthritis. Gait Posture 38(3):421–427. https://doi.org/10.1016/j.gaitpost.2013.01.001
Rudolph KS, Schmitt LC, Lewek MD (2007) Age-related changes in strength, joint laxity, and walking patterns: are they related to knee osteoarthritis? Phys Ther 87(11):1422–1432. https://doi.org/10.2522/ptj.20060137
Rutherford DJ, Hubley-Kozey CL, Stanish WD (2013) Changes in knee joint muscle activation patterns during walking associated with increased structural severity in knee osteoarthritis. J Electromyogr Kinesiol 23(3):704–711. https://doi.org/10.1016/j.jelekin.2013.01.003
Rutherford DJ, Hubley-Kozey CL, Stanish WD, Dunbar MJ (2011) Neuromuscular alterations exist with knee osteoarthritis presence and severity despite walking velocity similarities. Clin Biomech 26(4):377–383. https://doi.org/10.1016/j.clinbiomech.2010.11.018
Schnitzer TJ, Popovich JM, Andersson GB, Andriacchi TP (1993) Effect of piroxicam on gait in patients with osteoarthritis of the knee. Arthritis Rheum 36(9):1207–1213
Simon SR, Trieshmann HW, Burdett RG, Ewald FC, Sledge CB (1983) Quantitative gait analysis after total knee arthroplasty for monarticular degenerative arthritis. J Bone Joint Surg Am 65(5):605–613
Smith AJ, Lloyd DG, Wood DJ (2004) Pre-surgery knee joint loading patterns during walking predict the presence and severity of anterior knee pain after total knee arthroplasty. J Orthop Res 22(2):260–266. https://doi.org/10.1016/S0736-0266(03)00184-0
Smith AJ, Lloyd DG, Wood DJ (2006) A kinematic and kinetic analysis of walking after total knee arthroplasty with and without patellar resurfacing. Clin Biomech (Bristol, Avon) 21(4):379–386. https://doi.org/10.1016/j.clinbiomech.2005.11.007
Teixeira LF, Olney SJ (1996) Relationship between alignment and kinematic and kinetic measures of the knee of osteoarthritic elderly subjects in level walking. Clin Biomech (Bristol, Avon) 11(3):126–134
Thorp LE, Sumner DR, Block JA, Moisio KC, Shott S, Wimmer MA (2006) Knee joint loading differs in individuals with mild compared with moderate medial knee osteoarthritis. Arthritis Rheum 54(12):3842–3849. https://doi.org/10.1002/art.22247
Wegrzyn J, Parratte S, Coleman-Wood K, Kaufman KR, Pagnano MW (2013) The John Insall award: no benefit of minimally invasive TKA on gait and strength outcomes: a randomized controlled trial. Clin Orthop Relat Res 471(1):46–55. https://doi.org/10.1007/s11999-012-2486-1
Weidenhielm L, Svensson OK, Brostrom LA, Mattsson E (1994) Adduction moment of the knee compared to radiological and clinical parameters in moderate medical osteoarthrosis of the knee. Ann Chir Gynaecol 83(3):236–242
Wilson DAJ, Hubley-Kozey CL, Wilson JLA, Dunbar MJ (2012) Pre-operative muscle activation patterns during walking are associated with TKA tibial implant migration. Clin Biomech 27(9):936–942. https://doi.org/10.1016/j.clinbiomech.2012.06.012
Wilson SA, McCann PD, Gotlin RS, Ramakrishnan HK, Wootten ME, Insall JN (1996) Comprehensive gait analysis in posterior-stabilized knee arthroplasty. J Arthroplast 11(4):359–367
Yakhdani HR, Bafghi HA, Meijer OG, Bruijn SM, van den Dikkenberg N, Stibbe AB, van Royen BJ, van Dieen JH (2010) Stability and variability of knee kinematics during gait in knee osteoarthritis before and after replacement surgery. Clin Biomech (Bristol, Avon) 25(3):230–236. https://doi.org/10.1016/j.clinbiomech.2009.12.003
Yoshida Y, Mizner RL, Ramsey DK, Snyder-Mackler L (2008) Examining outcomes from total knee arthroplasty and the relationship between quadriceps strength and knee function over time. Clin Biomech (Bristol, Avon) 23(3):320–328. https://doi.org/10.1016/j.clinbiomech.2007.10.008
Zeni JA, Rudolph K, Higginson JS (2010) Alterations in quadriceps and hamstrings coordination in persons with medial compartment knee osteoarthritis. J Electromyogr Kinesiol 20(1):148–154. https://doi.org/10.1016/j.jelekin.2008.12.003
Zeni JA Jr, Higginson JS (2009) Differences in gait parameters between healthy subjects and persons with moderate and severe knee osteoarthritis: a result of altered walking speed? Clin Biomech 24(4):372–378. https://doi.org/10.1016/j.clinbiomech.2009.02.001
Author information
Authors and Affiliations
Corresponding author
Section Editor information
Rights and permissions
Copyright information
© 2018 Springer International Publishing AG, part of Springer Nature
About this entry
Cite this entry
Hubley-Kozey, C.L., Astephen Wilson, J. (2018). Effects of Knee Osteoarthritis and Joint Replacement Surgery on Gait. In: Handbook of Human Motion. Springer, Cham. https://doi.org/10.1007/978-3-319-14418-4_82
Download citation
DOI: https://doi.org/10.1007/978-3-319-14418-4_82
Published:
Publisher Name: Springer, Cham
Print ISBN: 978-3-319-14417-7
Online ISBN: 978-3-319-14418-4
eBook Packages: EngineeringReference Module Computer Science and Engineering