Photodynamic Therapy

  • Maria Claudia Almeida IssaEmail author
  • Diego Cerqueira Alexandre
Reference work entry
Part of the Clinical Approaches and Procedures in Cosmetic Dermatology book series (CAPCD, volume 1)


Photodynamic therapy (PDT) consists of a chemical reaction activated by light source that is used in the management of many skin diseases. The most extensively studied photosensitizing agents for PDT are 5-aminolevulinic and methyl aminolevulinate (MAL). The light sources used in photodynamic therapy should emit light at optimal wavelengths to excite the photosensitizer and produce reactive oxygen species. PDT should be considered as a therapeutic option, particularly in the case of non-melanoma skin cancer such as actinic keratosis, basal cell carcinoma, and Bowen disease. It can also be used in some inflammatory and infectious disease. Photorejuvenation is a new spectrum of PDT use, which is being widely studied. Daylight-mediated PDT is a new modality of PDT, which was developed to minimize patient discomfort, maintaining PDT efficacy. This chapter will approach its concept, mechanism of action, procedure, and indications.


Photodynamic therapy Non-melanoma skin cancer Photosensitizer Light source Skin rejuvenation Acne Daylight-mediated photodynamic therapy 


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Copyright information

© Springer International Publishing AG 2017

Authors and Affiliations

  • Maria Claudia Almeida Issa
    • 1
    Email author
  • Diego Cerqueira Alexandre
    • 2
  1. 1.Department of Clinical Medicine – DermatologyFluminense Federal UniversityNiteróiBrazil
  2. 2.Universidade Federal FluminenseNiteróiBrazil

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