Skip to main content

Nutraceuticals in Dermatology

  • Reference work entry
  • First Online:
  • 2292 Accesses

Part of the book series: Clinical Approaches and Procedures in Cosmetic Dermatology ((CAPCD,volume 1))

Abstract

Dietary factors play an essential role in cutaneous homeostasis since they supply the nutrients necessary for good cellular functioning. Any shortage of these elements can lead to dysfunctions of the cutaneous structure, often hard to identify, since the clinical condition is oligosymptomatic. Nutraceuticals are associations of nutrients with benefits and synergistic effects. They act not only in response to any minor shortage of micronutrients but also in phenomena at the cellular level, associated with aging, dermatoses, and the cellular cycle.

This is a preview of subscription content, log in via an institution.

Buying options

Chapter
USD   29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD   299.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Hardcover Book
USD   379.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Learn about institutional subscriptions

References

  • Addor FAS. Nutritional approach to skin aging: correlation between the effects on fibroblasts and clinical results. Surg Cosmet Dermatol. 2011;3(1):12–6.

    Google Scholar 

  • Addor FAS, Camarano P, Agelune C. Aumento da dose eritematosa mínima a partir da ingestão de um suplemento vitamínico contendo antioxidantes. Surg Cosmet Dermatol. 2013;5(3):212–5.

    Google Scholar 

  • Addor FAS, Bombarda PCP, Bombarda Júnior MS, Abreu FF. Influence of nutritional supplementation in the treatment of telogen effluvium: clinical assessment and digital phototrichogram in 60 patients. Surg Cosmet Dermatol. 2014;6(2):1316.

    Google Scholar 

  • Afaq F, Mukhtar H. Botanical antioxidants in the prevention of photocarcinogenesis and photoaging. Exp Dermatol. 2006;15(9):678–84.

    Article  CAS  PubMed  Google Scholar 

  • ANVISA. RESOLUÇÃO Nº 19, DE 30 DE ABRIL DE1999. http://portal.anvisa.gov.br/acessadoem (1999). 12 Oct 2015.

  • Arslan M, Vurucu S, Balamtekin N, Unay B, Akin R, Kurt I, Ozcan O. The effects of biotin supplementation on serum and liver tissue biotinidase enzyme activity and alopecia in rats which were administrated to valproic acid. Brain Dev. 2009;31(6):405–10.

    Article  PubMed  Google Scholar 

  • Baquerizo Nole KL, Yim E, Keri JE. Probiotics and prebiotics in dermatology. J Am Acad Dermatol. 2014;71(4):814–21.

    Article  PubMed  Google Scholar 

  • Boelsma E, Hendriks HFJ, Roza L. Nutritional skin care: health effects of micronutrients and fatty acids. Am J Clin Nutr. 2001;73:853–64.

    CAS  PubMed  Google Scholar 

  • Brenner S, Horwitz C. Possible nutrient mediators in psoriasis and seborrheic dermatitis. II. Nutrient mediators: essential fatty acids; vitamins A, E and D; vitamins B1, B2, B6, niacin and biotin; vitamin C selenium; zinc; iron. World Rev Nutr Diet. 1988;55:165–82.

    Article  CAS  PubMed  Google Scholar 

  • Breslow RA, Alberg AJ, Helzlsouer KJ, et al. Serological precursors of cancer: malignant melanoma, basal and squamous cell skin cancer, and prediagnostic levels of retinol, β-carotene, lycopene, α-tocopherol, and selenium. Cancer Epidemiol Biomark Prev. 1995;4(8):837–42.

    CAS  Google Scholar 

  • Bronsnick T, Murzaku EC, Rao BK. Diet in dermatology: part I. Atopic dermatitis, acne, and nonmelanoma skin cancer. J Am Acad Dermatol. 2014;71(6):1039.e1–1039.e12.

    Article  CAS  Google Scholar 

  • Burris J, Rietkerk W, Woolf K. Acne: the role of medical nutrition therapy. J Acad Nutr Diet. 2013;113:416–30.

    Article  PubMed  Google Scholar 

  • Chung JH, Han JH, Hwang EJ, Seo JY, Cho KH, Kim KH, Youn JI, Eun HC. Dual mechanisms of green tea extract (EGCG)-induced cell survival in human epidermal keratinocytes. FASEB J. 2003;17(13):1913–5.

    CAS  PubMed  Google Scholar 

  • Costa A, Lindmark L, Arruda LH, Assumpção EC, Ota FS, Pereira Mde O, Langen SS. Clinical, biometric and ultrasound assessment of the effects of daily use of a nutraceutical composed of lycopene, acerola extract, grape seed extract and Biomarine Complex in photoaged human skin. An Bras Dermatol. 2012;87(1):52–61.

    Article  PubMed  Google Scholar 

  • Darvin M, Patzelt A, Gehse S, Schanzer S, Benderoth C, Sterry W, Lademann J. Cutaneous concentration of lycopene correlates significantly with the roughness of the skin. Eur J Pharm Biopharm. 2008;69(3):943–7.

    Article  CAS  PubMed  Google Scholar 

  • Food Nutrition Board, Institute of Medicine. Dietary reference intakes for vitamin C, vitamin E, selenium and carotenoids. Washington, DC: National Academies Press; 2000.

    Google Scholar 

  • Foolad N, Armstrong AW. Prebiotics and probiotics: the prevention and reduction in severity of atopic dermatitis in children. Benefic Microbes. 2014;5(2):151–60.

    Article  CAS  Google Scholar 

  • Fu LW, Vender R. Systemic role for vitamin D in the treatment of psoriasis and metabolic syndrome. Dermatol Res Pract. 2011;2011:276079.

    PubMed  PubMed Central  Google Scholar 

  • Grassi M, Petraccia L, Mennuni G, Fontana M, Scarno A, Sabetta S, Fraioli A. Changes, functional disorders, and diseases in the gastrointestinal tract of elderly. Nutr Hosp. 2011;26(4):659–68.

    CAS  PubMed  Google Scholar 

  • Grover C, Khurana A. Telogen effluvium. Indian J Dermatol Venereol Leprol. 2013;79(5):591–603.

    Article  PubMed  Google Scholar 

  • Guaratini T, Medeiros MHG, Colepicolo P. Antioxidantes na manutenção do equilíbrio redox cutâneo. Quim Nova. 2007;30(1):206–13.

    Article  CAS  Google Scholar 

  • Hata TR, Audish D, Kotol P, Coda A, Kabigting F, Miller J, et al. A randomized controlled double-blind investigation of the effects of vitamin D dietary supplementation in subjects with atopic dermatitis. J Eur Acad Dermatol Venereol. 2014;28:781–9.

    Article  CAS  PubMed  Google Scholar 

  • Holick MF. Vitamin D Sunlight and Cancer Connection. Anticancer Agents Med Chem. 2012.

    Google Scholar 

  • Iovine B, Garofalo M, Orefice M, Giannini V, Gasparri F, Monfrecola G, Bevilacqua MA. Isoflavones in aglycone solution enhance ultraviolet B-induced DNA damage repair efficiency. Clin Exp Dermatol. 2014;39(3):391–4.

    Article  CAS  PubMed  Google Scholar 

  • Katta R, Brown DN. Diet and Skin Cancer: the potential role of dietary antioxidants in nonmelanoma skin cancer prevention. J Skin Cancer. 2015;2015:893149. doi:10.1155/2015/893149.10 pages

    Article  PubMed  PubMed Central  Google Scholar 

  • Kierszenbaum AL, Tres L. Histologia e biologia celular. Rio de Janeiro: Elsevier; 2012.

    Google Scholar 

  • Kil MS, Kim CW, Kim SS. Analysis of serum zinc and copper concentrations in hair loss. Ann Dermatol. 2013;25(4):405–9.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Kim JE, Shin MH, Chung JH. Epigallocatechin-3-gallate prevents heat shock-induced MMP-1 expression by inhibiting AP-1 activity in human dermal fibroblasts. Arch Dermatol Res. 2013;305(7):595.

    Article  CAS  PubMed  Google Scholar 

  • Kim SO, Ah YM, Yu YM, Choi KH, Shin WG, Lee JY Effects of probiotics for the treatment of atopic dermatitis: a meta-analysis of randomized controlled trials Ann Allergy Asthma Immunol. 2014 [Epub ahead of print].

    Google Scholar 

  • Liu T, Qi H, Ma L, Liu Z, Fu H, Zhu W, Song T, Yang B, Li G. Resveratrol attenuates oxidative stress and extends life span in the annual fish Nothobranchius guentheri. Rejuvenation Res. 2015;18(3):225–33.

    Article  CAS  PubMed  Google Scholar 

  • Maier HM, Ilich JZ, Kim JS, Spicer MT. Nutrition supplementation for diabetic wound healing: a systematic review of current literature. Skinmed. 2013;11(4):217–24.

    PubMed  Google Scholar 

  • Meinke MC, Friedrich A, Tscherch K, Haag SF, Darvin ME, Vollert H, Groth N, Lademann J, Rohn S. Influence of dietary carotenoids on radical scavenging capacity of the skin and skin lipids. Eur J Pharm Biopharm. 2013;84(2):365–73.

    Article  CAS  PubMed  Google Scholar 

  • Melnik BC. Diet in acne: further evidence for the role of nutrient signaling in acne pathogenesis. Acta Derm Venereol. 2012;92:228–31.

    Article  CAS  PubMed  Google Scholar 

  • Mock DM. Skin manifestations of biotin deficiency. Semin Dermatol. 1991;10(4):296–302.

    CAS  PubMed  Google Scholar 

  • Moeinvaziri M, Mansoori P, Holakooee K, Safaee Naraghi Z, Abbasi A. Iron status in diffuse telogen hair loss among women. Acta Dermatovenerol Croat. 2009;17(4):279–84.

    PubMed  Google Scholar 

  • Mohajeri S, Newman SA. Review of evidence for dietary influences on atopic dermatitis. Skin Therapy Lett. 2014;19(4):5–7.

    CAS  PubMed  Google Scholar 

  • Mulinari-Brenner F, Bergfeld W. Entendendo o Eflúvio Telógeno. An Bras Dermatol. 2002;77:87–94.

    Google Scholar 

  • Murzaku EC, Bronsnick T, Rao BK. Diet in dermatology: part II. Melanoma, chronic urticaria, and psoriasis. J Am Acad Dermatol. 2014;71(6):1053.e1–1053.e16.

    Article  Google Scholar 

  • Noonan WP, Noonan C. Legal requeriments for “functional foods” claims. Toxicol Lett. 2004;150:19–24.

    Article  CAS  PubMed  Google Scholar 

  • Offord EA, Gautier J-C, Avanti O, et al. Photoprotective potential of lycopene, β-carotene, vitamin E, vitamin C and carnosic acid in UVA-irradiated human skin fibroblasts. Free Radic Biol Med. 2002;32(12):1293–303.

    Article  CAS  PubMed  Google Scholar 

  • Plonka PM, Handjiski B, Popik M, Michalczyk D, Paus R. Zinc as an ambivalente but potent modulator of murine hair growth in vivo-preliminary observations. Exp Dermatol. 2005;14(11):844–53.

    Article  CAS  PubMed  Google Scholar 

  • Poljšak B, Dahmane R. Free radicals and extrinsic skin aging. Dermatol Res Pract. 2012;2012:135206. Epub 2012 Feb 29

    PubMed  PubMed Central  Google Scholar 

  • Poljsak B, Dahmane R, Godic A. Skin and antioxidants. J Cosmet Laser Ther. 2013;15(2):107–13.

    Article  PubMed  Google Scholar 

  • Rushton DH. Nutritional factors and hair loss. Clin Exp Dermatol. 2002;27:396–404.

    Article  CAS  PubMed  Google Scholar 

  • Shrivastava SB. Diffuse hair loss in an adult female: approach to diagnosis and management. Indian J Dermatol Venereol Leprol. 2009;75(1):20–8.

    Article  PubMed  Google Scholar 

  • Sies H, Stahl W. Nutritional protection against skin damage from sunlight. Annu Rev Nutr. 2004;24:173–200.

    Google Scholar 

  • Siro I et al. Functional food. Product development, marketing and consumer acceptance – a review. Appetite. 2008;51(3):456–67.

    Article  PubMed  Google Scholar 

  • Söderström L, Thors Adolfsson E, Rosenblad A, Frid H, Saletti A, Bergkvist L. Mealtime habits and meal provision are associated with malnutrition among elderly patients admitted to hospital. Clin Nutr. 2013 Apr;32(2):281–8.

    Google Scholar 

  • Stechmiller JK. Understanding the role of nutrition and wound healing. Nutr Clin Pract. 2010;25(1):61–8.

    Article  PubMed  Google Scholar 

  • Tong LX, Young LC. Nutrition: the future of melanoma prevention? J Am Acad Dermatol. 2014;71(1):151–60.

    Article  CAS  PubMed  Google Scholar 

  • Xia S, Lu Y, Wang J, He C, Hong S, Serhan CN, et al. Melanoma growth is reduced in fat-1 transgenic mice: impact of omega-6/omega-3 essential fatty acids. Proc Natl Acad Sci. 2006;103:12499–504.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Flávia Alvim Sant’Anna Addor .

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2017 Springer International Publishing AG

About this entry

Cite this entry

Addor, F.A.S., Ravelli, F.N. (2017). Nutraceuticals in Dermatology. In: Issa, M., Tamura, B. (eds) Daily Routine in Cosmetic Dermatology. Clinical Approaches and Procedures in Cosmetic Dermatology, vol 1. Springer, Cham. https://doi.org/10.1007/978-3-319-12589-3_20

Download citation

  • DOI: https://doi.org/10.1007/978-3-319-12589-3_20

  • Published:

  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-12588-6

  • Online ISBN: 978-3-319-12589-3

  • eBook Packages: MedicineReference Module Medicine

Publish with us

Policies and ethics