Abstract
This chapter describes the current approaches to reduce bacterial adhesion to various biomaterial surfaces, focusing on nonfouling surfaces through patterning and hydrophobicity plasma-assisted surface treatment and deposition; incorporation of antimicrobials, antibiotics, antibiofilms, and natural extracts that are either immobilized or released; dual function antimicrobial surfaces; incorporation of nonpathogenic bacteria, bacteriophages, and biofilm dispersal agents but also reduced bacterial adhesion through tissue integration. To facilitate the design of new materials, the role of physical, chemical, and biological surface properties on bacterial adhesion is reviewed in each case, as an insight into the chemical and physical cues that affect bacterial adhesion and biofilm formation can provide ideas for creating successful antifouling or antimicrobial surfaces. The application of these surfaces is explored based on the clinical needs and the market gaps. How multidisciplinary research on surface design and engineering may have an impact on both fundamental understanding of bacterial adhesion to biomaterials and applied biomaterial science and technology is finally discussed.
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Acknowledgement
MGK work for this chapter was partially funded by WELMEC, Centre of Excellence in Medical Engineering funded by the Wellcome Trust and EPSRC, under grant number WT 088908/Z/09/Z. Professor REW Hancock is acknowledged for providing the peptides used in Fig. 3 and Ref. [44] and Professor DD Devine for valuable discussions on peptides antimicrobial properties. Dr. S Patel (Fluxion Ltd.) is acknowledged for his help with the BioFlux, a microfluidic system used for the biofilm formation presented in Fig. 3.
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Katsikogianni, M.G., Wood, D.J., Missirlis, Y.F. (2016). Biomaterial Functionalized Surfaces for Reducing Bacterial Adhesion and Infection. In: Antoniac, I. (eds) Handbook of Bioceramics and Biocomposites. Springer, Cham. https://doi.org/10.1007/978-3-319-12460-5_32
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