Encyclopedia of Bioastronautics

Living Edition
| Editors: Laurence R. Young, Jeffrey P. Sutton

Immunology

  • Judith-Irina BuchheimEmail author
  • Brian Crucian
  • Alexander Choukèr
Living reference work entry
DOI: https://doi.org/10.1007/978-3-319-10152-1_23-1

Synonyms

Definition

Immunology defines the study of all properties of the immune system including its structure and its function, the bodily distinction between self and nonself, innate and acquired immunity, and immunization. For the host defense in health and disease, it investigates especially the relationship between invading pathogens and the triggered immune responses of the organism. Immune effector mechanisms are altered in space by the unique conditions of this perilous environment (radiation, confinement, μG) together with stress hormone-related modifications. To understand the changes that occur during short- and long-term spaceflight and to counteract appropriately to prevent disease, in-flight immune monitoring will become pivotal.

Detailed Description

General Principles of Human Host Defense

During everyday life, a human being encounters a multitude of microorganisms and potential pathogens. Disease, however, will...

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References

  1. Alberts B (2014) Molecular biology of the cell, 6th edn. Garland Science, Taylor & Francis Group LLC, New YorkCrossRefGoogle Scholar
  2. Barratt MR, Pool SL (2008) Principles of clinical medicine for space flight. Springer Science and Business Media, LLC, New YorkCrossRefGoogle Scholar
  3. Busby DE (1968) Space clinical medicine. Reidel, DordrechtCrossRefGoogle Scholar
  4. Clément G, Vico L, Choukèr A (2011) Human physiology. In: Beysens D, Carotenuto L, van Loon JJWA, Zell M (eds) Laboratory science with space data. Springer, Berlin/HeidelbergGoogle Scholar
  5. Cogoli A, Tschopp A, Fuchs-Bislin P (1984) Cell sensitivity to gravity. Science 225:228–230CrossRefGoogle Scholar
  6. Cogoli A, Iverson TH, Johnsson A, Mesland D, Oser H (1989) Cell biology. In: Oser H, Battrick B (eds) Life sciences research in space. ESA Publications Division (ESA SP-1105), Noordwijk, pp 49–64Google Scholar
  7. Cogoli-Greuter M, Sciola L, Pippia P, Bechler B, Sechi G, Lorenzi G, Cogoli A (1997) In: Cogoli A, Friedrich U, Mesland D, Demets R (eds) Life sciences experiments performed on sounding rockets (1985–1994). ESA Publications Division (ESA SP-1206), Noordwijk, pp 59–70Google Scholar
  8. Crucian B (2015) Risk of crew adverse health event due to altered immune response, human research program, human health countermeasures element evidence report. National Aeronautics and Space Administration Lyndon B. Johnson Space Center, HoustonGoogle Scholar
  9. Crucian B, Choukèr A (2012) Immune system in space: general introduction and observations on stress-sensitive regulations. In: Choukèr A (ed) Stress challenges and immunity in space. Springer, Heidelberg, pp 127–139CrossRefGoogle Scholar
  10. Crucian B, Sams C (2012) Adaptive immunity and spaceflight. In: Choukèr A (ed) Stress challenges and immunity in space. Springer, Heidelberg, pp 165–175CrossRefGoogle Scholar
  11. Feuerecker M (2012) Innate immunity under conditions of space flight. In: Choukèr A (ed) Stress challenges and immunity in space. Springer, Heidelberg, pp 141–153CrossRefGoogle Scholar
  12. Morukov B, Rykova M, Antropova E (2012) NK cells assessments: a thirty-year-old history of immune stress interaction in space. In: Choukèr A (ed) Stress challenges and immunity in space. Springer, Heidelberg, pp 155–164CrossRefGoogle Scholar
  13. Murphy KP (2012) Janeway’s immunobiology, 8th edn. Garland Science, Taylor & Francis Group LLC, New YorkGoogle Scholar
  14. Pits JA (1985) The human factor-biomedicine in the manned space program to 1980. NASA History Series History I, Title II, Series III. National Aeronautics and Space Administration Lyndon B. Johnson Space Center, HoustonGoogle Scholar
  15. Wotring VE (2012) Space pharmacology. Springer, New YorkCrossRefGoogle Scholar
  16. Yi B, Crucian B, Tauber S, Ullrich O, Choukèr A (2016) Immune dysfunction in spaceflight – an integrative view. In: Nickerson CA, Pellis NR, Ott CM (eds) Effect of spaceflight and spaceflight analogue culture on human and microbial cells: novel insights into disease mechanisms. Springer, New YorkGoogle Scholar

Copyright information

© Springer Nature Switzerland AG 2019

Authors and Affiliations

  • Judith-Irina Buchheim
    • 1
    Email author
  • Brian Crucian
    • 2
  • Alexander Choukèr
    • 1
  1. 1.Laboratory of Translational Research Stress and Immunity, Department of AnesthesiologyUniversity Hospital of Munich, LMUMunichGermany
  2. 2.Immunology Laboratory, NASA-Johnson Space CenterHoustonUSA

Section editors and affiliations

  • Peter Norsk
    • 1
    • 2
  1. 1.Center for Space MedicineBaylor College of MedicineHoustonUSA
  2. 2.Biomedical Research & Environmental Sciences DivisionNASA, Johnson Space CenterHoustonUSA