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In Pursuit of the “Ideal” Outcome After Pediatric Liver Transplantation

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Solid Organ Transplantation in Infants and Children

Part of the book series: Organ and Tissue Transplantation ((OTT))

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Abstract

The best outcome for pediatric liver transplant recipients require effective interdisciplinary teams with diverse competencies who work in a coordinated fashion toward common goals including to (i) define the best possible outcome for pediatric LT recipients and (ii) identify and close gaps in current care processes requiring acquisition of strategies and application of new discoveries which would ultimately improve the care delivery system. Focused action plan items were developed for patient selection and peri-transplant risk; cardiac, renal, and infectious disease evaluation; allocation, donor selection and organ procurement; graft rescue; and long-term graft maintenance and adherence.

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References

  • Ancora D, Bresman H. X-teams: How to Build Teams That Lead, Innovate and Succeed. First ed: Harvard Business School Press; 2007.

    Google Scholar 

  • Bucuvalas JC, Alonso E, Magee JC, Talwalkar J, Hanto D, Doo E (2008) Improving long-term outcomes after liver transplantation in children. Am J Transplant 8(12):2506–2513. doi:10.1111/j.1600-6143.2008.02432.x

    Article  CAS  PubMed  Google Scholar 

  • Bucuvalas J, Filipovich L, Yazigi N, Narkewicz MR, Ng V, Belle SH, …, Squires RH (2013) Immunophenotype predicts outcome in pediatric acute liver failure. J Pediatr Gastroenterol Nutr 56(3):311–315. doi:10.1097/MPG.0b013e31827a78b2

    Google Scholar 

  • Celtik C, Durmaz O, Oner N, Yavuz T, Gokce S, Aydogan A, …, Sokucu S (2015) Investigation of cardiomyopathy in children with cirrhotic and noncirrhotic portal hypertension. J Pediatr Gastroenterol Nutr 60(2):177–181. doi:10.1097/mpg.0000000000000580

    Google Scholar 

  • Chawla LS, Eggers PW, Star RA, Kimmel PL (2014) Acute kidney injury and chronic kidney disease as interconnected syndromes. N Engl J Med 371(1):58–66. doi:10.1056/NEJMra1214243

    Article  PubMed  Google Scholar 

  • Danziger-Isakov L, Bucavalas J (2014) Current prevention strategies against cytomegalovirus in the studies in pediatric liver transplantation (SPLIT) centers. Am J Transplant 14(8):1908–1911. doi:10.1111/ajt.12755

    Article  CAS  PubMed  Google Scholar 

  • Desai MS, Zainuer S, Kennedy C, Kearney D, Goss J, Karpen SJ (2011) Cardiac structural and functional alterations in infants and children with biliary atresia, listed for liver transplantation. Gastroenterology 141(4):1264–1272, e1261–1264. doi:10.1053/j.gastro.2011.06.082

    Google Scholar 

  • Ekong UD, Melin-Aldana H, Seshadri R, Lokar J, Harris D, Whitington PF, Alonso EM (2008) Graft histology characteristics in long-term survivors of pediatric liver transplantation. Liver Transpl 14(11):1582–1587. doi:10.1002/lt.21549

    Article  PubMed  Google Scholar 

  • Englesbe MJ, Kelly B, Goss J, Fecteau A, Mitchell J, Andrews W, …, Bucuvalas J (2012) Reducing pediatric liver transplant complications: a potential roadmap for transplant quality improvement initiatives within North America. Am J Transplant 12(9):2301–2306. doi:10.1111/j.1600-6143.2012.04204.x

    Google Scholar 

  • Fredericks EM, Lopez MJ, Magee JC, Shieck V, Opipari-Arrigan L (2007) Psychological functioning, nonadherence and health outcomes after pediatric liver transplantation. Am J Transplant 7(8):1974–1983. doi:10.1111/j.1600-6143.2007.01878.x

    Article  CAS  PubMed  Google Scholar 

  • Fredericks EM, Dore-Stites D, Well A, Magee JC, Freed GL, Shieck V, James Lopez M (2010) Assessment of transition readiness skills and adherence in pediatric liver transplant recipients. Pediatr Transplant 14(8):944–953. doi:10.1111/j.1399-3046.2010.01349.x

    Article  PubMed  PubMed Central  Google Scholar 

  • Ghaferi AA, Dimick JB (2015) Understanding failure to rescue and improving safety culture. Ann Surg. doi:10.1097/sla.0000000000001135

    Google Scholar 

  • Ghaferi AA, Birkmeyer JD, Dimick JB (2009) Variation in hospital mortality associated with inpatient surgery. N Engl J Med 361(14):1368–1375. doi:10.1056/NEJMsa0903048

    Article  CAS  PubMed  Google Scholar 

  • Goldstein SL, Kirkendall E, Nguyen H, Schaffzin JK, Bucuvalas J, Bracke T, …, Muething S (2013) Electronic health record identification of nephrotoxin exposure and associated acute kidney injury. Pediatrics 132(3): e756–767. doi:10.1542/peds.2013-0794

    Google Scholar 

  • Gurevich M, Guy-Viterbo V, Janssen M, Stephenne X, Smets F, Sokal E, …, Reding R (2015) Living donor liver transplantation in children: surgical and immunological results in 250 recipients at Universite Catholique de Louvain. Ann Surg. doi:10.1097/sla.0000000000001094

    Google Scholar 

  • Hsu EK, Shaffer M, Bradford M, Mayer-Hamblett N, Horslen S (2015) Heterogeneity and disparities in the use of exception scores in pediatric liver allocation. Am J Transplant 15(2):436–444. doi:10.1111/ajt.13089

    Article  CAS  PubMed  Google Scholar 

  • Kim WR, Lake JR, Smith JM, Skeans MA, Schladt DP, Edwards EB, …, Kasiske BL (2015) OPTN/SRTR 2013 annual data report: liver. Am J Transplant 15(Suppl 2):1–28. doi:10.1111/ajt.13197

    Google Scholar 

  • Kivela JM, Kosola S, Kalajoki-Helmio T, Makisalo H, Jalanko H, Holmberg C, …, Lauronen J (2014) Late hepatic artery thrombosis after pediatric liver transplantation: a cross-sectional study of 34 patients. Liver Transpl 20(5):591–600. doi:10.1002/lt.23852

    Google Scholar 

  • Magee JC, Feng S (2005) PELD: working well, but only half of the time? Am J Transplant 5(8):1785–1786. doi:10.1111/j.1600-6143.2005.00990.x

    Article  PubMed  Google Scholar 

  • Menon S, Kirkendall ES, Nguyen H, Goldstein SL (2014) Acute kidney injury associated with high nephrotoxic medication exposure leads to chronic kidney disease after 6 months. J Pediatr 165(3):522–527, e522. doi:10.1016/j.jpeds.2014.04.058

    Google Scholar 

  • Meyers RL, Tiao GM, Dunn SP, McGahren ED 3rd, Langham MR Jr (2012) Surgical management of children with locally advanced hepatoblastoma. Cancer 118(16):4090–4091; author reply 4094–4095. doi:10.1002/cncr.26715

    Google Scholar 

  • Miyagawa-Hayashino A, Yoshizawa A, Uchida Y, Egawa H, Yurugi K, Masuda S, …, Haga H (2012) Progressive graft fibrosis and donor-specific human leukocyte antigen antibodies in pediatric late liver allografts. Liver Transpl 18(11):1333–1342. doi:10.1002/lt.23534

    Google Scholar 

  • Network OPaT (2015) Transplants in the U.S. by recipient age. Retrieved 8 June 2015, from http://optn.transplant.hrsa.gov/converge/latestData/rptData.asp

  • Neuberger J (2010) Surgery: day or night – does the time of liver transplantation matter? Nat Rev Gastroenterol Hepatol 7(11):596–597. doi:10.1038/nrgastro.2010.156

    Article  PubMed  Google Scholar 

  • Ng VL, Alonso EM, Bucuvalas JC, Cohen G, Limbers CA, Varni JW, …, Anand R (2012) Health status of children alive 10 years after pediatric liver transplantation performed in the US and Canada: report of the studies of pediatric liver transplantation experience. J Pediatr 160(5):820–826 e823. doi:10.1016/j.jpeds.2011.10.038. S0022-3476(11)01123-1 [pii]

    Google Scholar 

  • Porter ME (2010) What is value in health care? N Engl J Med 363(26):2477–2481. doi:10.1056/NEJMp1011024

    Article  CAS  PubMed  Google Scholar 

  • Shemesh E, Shneider BL, Savitzky JK, Arnott L, Gondolesi GE, Krieger NR, …, Emre S (2004) Medication adherence in pediatric and adolescent liver transplant recipients. Pediatrics 113(4):825–832

    Google Scholar 

  • Soltys KA, Mazariegos GV, Squires RH, Sindhi RK, Anand R (2007) Late graft loss or death in pediatric liver transplantation: an analysis of the SPLIT database. Am J Transplant 7(9):2165–2171. doi:10.1111/j.1600-6143.2007.01893.x

    Article  CAS  PubMed  Google Scholar 

  • Squires RH, Ng V, Romero R, Ekong U, Hardikar W, Emre S, Mazariegos GV (2014) Evaluation of the pediatric patient for liver transplantation: 2014 practice guideline by the American Association for the Study of Liver Diseases, American Society of Transplantation and the North American Society for Pediatric Gastroenterology, Hepatology and Nutrition. Hepatology 60(1):362–398. doi:10.1002/hep.27191

    Article  PubMed  Google Scholar 

  • Turgeon N, Schnier K, Kaplan B (2013) Risky business: models of risk in transplant. Am J Transplant 13(5):1121–1122. doi:10.1111/ajt.12207

    Article  CAS  PubMed  Google Scholar 

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Author information

Authors and Affiliations

  1. Division of Pediatric Gastroenterology, Hepatology and Nutrition and SickKids Transplant and Regenerative Medicine Center, The Hospital for Sick Children, University of Toronto, 555 University Avenue, M5G 1X8, Toronto, ON, Canada

    Vicky Lee Ng

  2. Division of Pediatric Gastroenterology, Hepatology and Nutrition, Cincinnati Children’s Hospital, Cincinnati, OH, USA

    John C. Bucuvalas

Authors
  1. Vicky Lee Ng
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  2. John C. Bucuvalas
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Corresponding author

Correspondence to John C. Bucuvalas .

Editor information

Editors and Affiliations

  1. Jefferson Medical College, AI Dupont Hospital for Children Department of Surgery, Wilmington, Delaware, USA

    Stephen P. Dunn

  2. Liver & Intestine Transplantation, Seattle Children’s Hospital Liver & Intestine Transplantation, Seattle, Washington, USA

    Simon Horslen

Section Editor information

  1. Division of Gastroenterology, Hepatology and Nutrition, The Hospital for Sick Children, 555 University Avenue, M5G 1X8, Toronto, ON, Canada

    Vicky Lee Ng

  2. Pediatric Liver Care Center, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH, USA

    John C. Bucuvalas

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Ng, V.L., Bucuvalas, J.C. (2017). In Pursuit of the “Ideal” Outcome After Pediatric Liver Transplantation. In: Dunn, S., Horslen, S. (eds) Solid Organ Transplantation in Infants and Children. Organ and Tissue Transplantation. Springer, Cham. https://doi.org/10.1007/978-3-319-08049-9_7-1

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  • DOI: https://doi.org/10.1007/978-3-319-08049-9_7-1

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-08049-9

  • Online ISBN: 978-3-319-08049-9

  • eBook Packages: Springer Reference MedicineReference Module Medicine

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