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Late Allograft Loss of Function: Recurrence of Disease, Chronic Allograft Injury (Immune and Nonimmune Mediated), and Re-transplantation

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Solid Organ Transplantation in Infants and Children

Part of the book series: Organ and Tissue Transplantation ((OTT))

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Abstract

Renal transplantation is accepted as the treatment of choice for children with end-stage renal disease (ESRD). Over the past decade, improved short-term graft survival has been observed in children and adults with kidney transplantation; however, long-term survival has not improved. The causes of renal allograft dysfunction vary with the time after transplantation. Slowly progressive renal disease that occurs over a period of years after renal transplantation most commonly results from chronic allograft injury, calcineurin inhibitor toxicity, hypertensive nephrosclerosis, viral infections, and recurrent or de novo renal disease. Preventable causes of late allograft failure are important to identify in order to improve the long-term successful outcome of allograft survival. Re-transplantation in the pediatric population is likely to be common into adulthood. Primary reasons for late allograft failure will impact the success of re-transplantation.

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Authors and Affiliations

  1. Division of Nephrology, The Children’s Hospital of Philadelphia, Philadelphia, PA, USA

    H. Jorge Baluarte & Jo Ann Palmer

Authors
  1. H. Jorge Baluarte
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  2. Jo Ann Palmer
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Correspondence to H. Jorge Baluarte or Jo Ann Palmer .

Editor information

Editors and Affiliations

  1. Jefferson Medical College, AI Dupont Hospital for Children Department of Surgery, Wilmington, Delaware, USA

    Stephen P. Dunn

  2. Liver & Intestine Transplantation, Seattle Children’s Hospital Liver & Intestine Transplantation, Seattle, Washington, USA

    Simon Horslen

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© 2016 Springer International Publishing Switzerland

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Baluarte, H.J., Palmer, J.A. (2016). Late Allograft Loss of Function: Recurrence of Disease, Chronic Allograft Injury (Immune and Nonimmune Mediated), and Re-transplantation. In: Dunn, S., Horslen, S. (eds) Solid Organ Transplantation in Infants and Children. Organ and Tissue Transplantation. Springer, Cham. https://doi.org/10.1007/978-3-319-08049-9_34-1

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  • DOI: https://doi.org/10.1007/978-3-319-08049-9_34-1

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  • Publisher Name: Springer, Cham

  • Online ISBN: 978-3-319-08049-9

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