Skip to main content
SpringerLink
Log in

Intensive Care of the Child After Kidney Transplantation

  • Reference work entry
  • First Online:
Solid Organ Transplantation in Infants and Children

Part of the book series: Organ and Tissue Transplantation ((OTT))

  • 811 Accesses

Abstract

A multidisciplinary team including pediatric transplant surgeons or urologists, pediatric nephrologists, and specialized nurses is needed to provide optimal care after a renal transplant. Perioperative clinical and surgical complications requiring particularly close follow-up include fluid and electrolyte management, blood pressure control, and graft function surveillance. Timely imaging is required in the first postoperative day, using Doppler ultrasound to evaluate for compromised graft blood flow. Immunosuppressive therapy is key to graft survival and is optimized in the initial perioperative period.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 549.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Hardcover Book
USD 799.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  • Bakr MA, Denewar AA, Abbas MH (2016) Challenges for Renal Retransplant: an overview. Exp Clin Transplant 14(Suppl 3):21–26

    PubMed  Google Scholar 

  • Brunkhorst LC, Fichtner A, Höcker B, Burmeister G, Ahlenstiel-Grunow T, Krupka K et al (2015) Efficacy and safety of an Everolimus- vs. a mycophenolate Mofetil-based regimen in pediatric renal transplant recipients. PLoS One 10(9):e0135439

    Article  PubMed Central  PubMed  Google Scholar 

  • Cameron C, Vavilis G, Kowalski J et al (2014) An observational cohort study of the effect of hypertension on the loss of renal function in paediatric kidney recipients. Am J Hypertens 27:579–585

    Article  PubMed  Google Scholar 

  • Cameron BM, Kennedy SE, Rawlinson WD, Mackie FE (2016) The efficacy of valganciclovir for prevention of infections with cytomegalovirus and Epstein-Barr virus after kidney transplant in children. Pediatr Transplant 21:1–11

    Google Scholar 

  • Campos L, Parada B, Furriel F, Castelo D, Moreira P, Mota A (2012) Do intraoperative hemodynamic factors of the recipient influence renal graft function? Transplant Proc 44(6):1800–1803

    Article  CAS  PubMed  Google Scholar 

  • Dharnidharka VR, Fiorina P, Harmon W (2014) Kidney transplantation in children. N Engl J Med 371:549–558

    Article  CAS  PubMed  Google Scholar 

  • Drake K, Nehus E, Goebel J (2015) Hyponatremia, hypo-osmolality, and seizures in children early post-kidney transplant. Pediatr Transplant 19:698–703. https://doi.org/10.1111/petr.12575

    Article  CAS  PubMed  Google Scholar 

  • Faguer S, Kamar N, Guilbeaud-Frugier C et al (2007) Rituximab therapy for acute humoral rejection after kidney transplantation. Transplantation 83:1277–1280

    Article  CAS  PubMed  Google Scholar 

  • Ghirardo G, De Franceschi M, Vidal E et al (2014) Transplant renal artery stenosis in children: risk factors and outcome after endovascular treatment. Pediatr Nephrol 29:461

    Article  PubMed  Google Scholar 

  • Ghosh PS, Kwon C, Klein M, Corder J, Ghosh D (2014) Neurologic complications following pediatric renal transplantation. J Child Neurol 29(6):793–798

    Article  PubMed  Google Scholar 

  • Giussani A, Ardissino G, Belingheri M, Dilena R, Raiteri M, Pasciucco A, Colico C, Beretta C (2016) Posterior reversible encephalopathy syndrome after kidney transplantation in pediatric recipients: two cases. Pediatr Transplant 20:68–71

    Article  PubMed  Google Scholar 

  • Grenda R (2015) Biologics in renal transplantation. Pediatr Nephrol 30:1087

    Article  PubMed  Google Scholar 

  • Gulhan B, Topaloglu R, Karabulut E et al (2014) Post-transplant hypertension in paediatric kidney transplant recipients. Pediatr Nephrol 29:1075–1080

    Article  PubMed  Google Scholar 

  • Guzzo I, Morolli F, Camassei FD et al (2017) Acute kidney transplant rejection mediated by angiotensin II type 1 receptor antibodies in a pediatric hyperimmune patient. Pediatr Nephrol 32:185

    Article  PubMed  Google Scholar 

  • Haas M (2014) An updated Banff schema for diagnosis of antibody mediated rejection in renal allografts. Curr Opin Organ Transplant 19(3):315–322

    Article  CAS  PubMed  Google Scholar 

  • Hamdani G, Nehus EJ, Hooper DK, Mitsnefes MM (2016) Masked hypertension and allograft function in pediatric and young adults kidney transplant recipients. Pediatr Transplant 20:1026–1031

    Article  CAS  PubMed  Google Scholar 

  • Hocker B, Zencke S, Krupka K, Fichtner A, Pape L, Dello Strologo L, Guzzo I, Topaloglu R, Kranz B, Konig J, Bald M, Webb NJA, Noyan A, Dursun H, Marks S, Yalcinkaya F, Thiel F, Billing H, Pohl M, Fehrenbach H, Bruckner T, Tonshoff B (2016) Cytomegalovirus infection in pediatric renal transplantation and the impact of chemoprophylaxis with (Val-)ganciclovir. Transplantation 100(4):862–870

    Article  PubMed  Google Scholar 

  • Hoorn EJ (2016) Intravenous fluids: balancing solutions. J Nephrol 30:485. [Epub ahead of print]

    Article  PubMed Central  PubMed  Google Scholar 

  • Jordan CL, Taber DJ, Kyle MO, Connelly J, Pilch NW, Fleming J, Meadows HB, Bratton CF, Nadig SN, McGillicuddy JW, Chavin KD, Baliga PK, Shatat IF, Twombley K (2016) Incidence, risk factors, and outcomes of opportunistic infections in pediatric renal transplant recipients. Pediatr Transplant 20:44–48

    Article  PubMed  Google Scholar 

  • Kim IK, Choi J, Vo AA, Kang A, Patel M, Toyoda M, Mirocha J, Kamil ES, Louis Cohen J, Louie S, Galera O, Jordan SC, Puliyanda DP (2016) Safety and efficacy of Alemtuzumab induction in highly sensitized pediatric renal transplant recipients. Transplantation 101:883. Publish Ahead of Print

    Article  Google Scholar 

  • Kim MU, Kim SY, Park YH. A case of tacrolimus-induced encephalopathy after kidney transplantation. Korean J Pediatr 2011;54(1):40–45

    Google Scholar 

  • Koshy SM, Guttmann A, Hebert D et al (2009) Incidence and risk factors for cardiovascular events and death in paediatric renal transplant patients: a single centre long-term outcome study. Pediatr Transplant 13:1027–1033

    Article  PubMed  Google Scholar 

  • Lim WH, McDonald SP, Kennedy SE, Larkins N, Wong G (2016) Association between slow and delayed graft function with graft outcomes in Paediatric and adolescent deceased donor kidney transplant recipients. Transplantation 101:1906

    Article  Google Scholar 

  • McCoy H (2008) Posterior reversible encephalopathy syndrome: an emerging clinical entity in adult, pediatric, and obstetric critical care. J Am Acad Nurse Pract 20(2):100–106

    Article  Google Scholar 

  • Mitsnefes MM, Khoury PR, McEnery PT (2003) Early posttransplantation hypertension and poor long-term renal allograft survival in paediatric patients. J Pediatr 143:98–103

    Article  PubMed  Google Scholar 

  • Mueller T (2007) Mechanisms of action of thymoglobulin. Transplantation 84(11):S5–S10

    Article  CAS  Google Scholar 

  • Ng YW, Singh M, Sarwal MM (2015) Antibody-mediated rejection in pediatric kidney transplantation: pathophysiology, diagnosis, and management. Drugs 75:455

    Article  CAS  PubMed  Google Scholar 

  • Opelz G, Dohler B (2005) Improved long-term outcomes after renal transplantation associated with blood pressure control. Am J Transplant 5:2725–2731

    Article  PubMed  Google Scholar 

  • Peruzzi L, Amore A, Coppo R (2014) Challenges in pediatric renal transplantation. World J Transplant 4(4):222–228

    Article  PubMed Central  PubMed  Google Scholar 

  • Pirojsakul K, Desai D, Lacelle C et al (2016) Management of sensitized pediatric patients prior to renal transplantation. Pediatr Nephrol 31:1691

    Article  PubMed  Google Scholar 

  • Santoveña AZ, Meseguer CG, Mejia SM, Melgar AA, Camblor CF, Hijosa MM, Carrion AP, Roman LE. BK Virus Infection in Pediatric Renal Transplantation. Transplant Proc. 2015 Jan-Feb;47(1):62–6

    Google Scholar 

  • Sautenet B, Blancho G, Büchler M et al (2015) One-year results of the effects of rituximab on acute antibody-mediated rejection in renal transplantation: RITUX ERAH, a multicenter double-blind randomized placebo-controlled trial. Transplantation 100:391–399

    Article  Google Scholar 

  • Seeman T (2009) Hypertension after renal transplantation. Pediatr Nephrol 24:959–972

    Article  PubMed  Google Scholar 

  • Sierralta MC, González G, Nome C, Pinilla C, Correa R, Mansilla J, Rodríguez J, Delucchi A, Ossandón F (2015) Kidney transplant in pediatric patients with severe bladder pathology. Pediatr Transplant 19:675–683

    Article  PubMed  Google Scholar 

  • Smith JM (2015) Viral surveillance and subclinical viral infection in pediatric kidney transplantation. Pediatr Nephrol 30:741

    Google Scholar 

  • Sollinger H et al (2001) Basiliximab versus antithymocyte globulin for prevention of acute renal allograft rejection. Transplantation 72(12):1915–1919

    Article  CAS  PubMed  Google Scholar 

  • Tai-Heng Chen MD, Wei-Chen Lin MD, Yong-Hao Tseng MD, Chien-Ming Tseng MD, Tai-Tsung Chang MD, Tzeng-Jih Lin MD (2013) Posterior reversible encephalopathy syndrome in children. J Child Neurol 28(11):1378–1386

    Article  PubMed  Google Scholar 

  • Taylor K, Kim WT, Maharramova M, Figueroa V, Ramesh S, Lorenzo A (2016) Intraoperative management and early postoperative outcomes of pediatric renal transplants. Paediatr Anaesth 26:987–991

    Article  PubMed  Google Scholar 

  • Torricelli FCM, Watanabe A, David-Neto E, Nahas WC (2014) Current management issues of immediate postoperative care in pediatric kidney transplantation. Clinics 69(Suppl 1):39–41

    Article  PubMed Central  PubMed  Google Scholar 

  • Trachtman H, Frymoyer A, Lewandowski A, Greenbaum L, Feig D, Gipson D, Warady B, Goebel J, Schwartz G, Lewis K, Anand R, Patel U, on behalf of the Best Pharmaceuticals for Children Act–Pediatric Trials Network Administrative Core Committee (2015) Pharmacokinetics, pharmacodynamics, and safety of Lisinopril in pediatric kidney transplant patients: implications for starting dose selection. Clin Pharmacol Ther 98:25–33

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  • Varela-Fascinetto G, Benchimol C, Reyes-Acevedo R, Genevray M, Bradley D, Ives J, Silva HT Jr (2016) Tolerability of up to 200 days of prophylaxis with valganciclovir oral solution and/or film-coated tablets in pediatric kidney transplant recipients at risk of cytomegalovirus disease. Pediatr Transplant 21:1–11

    Google Scholar 

  • Verghese PS (2016) Pediatric kidney transplantation: a historical review. Pediatr Res 81:259

    Article  PubMed  Google Scholar 

  • Weber LT (2015) Therapeutic drug monitoring in pediatric renal transplantation. Pediatr Nephrol 30:253

    Article  PubMed  Google Scholar 

  • Weir MR, Burgess ED et al (2015) Assessment and Management of Hypertension in Transplant Patients. JASN 26:1248–1260. Epub ahead of print

    Article  CAS  PubMed Central  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Nemours Alfred I. duPont Hospital for Children, Wilmington, DE, USA

    Nicholas Slamon

  2. Pediatric Critical Care Medicine, NYU Langone Medical Center, New York, NY, USA

    Alan Salas

Authors
  1. Alan Salas
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Nicholas Slamon
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Alan Salas .

Editor information

Editors and Affiliations

  1. Department of Surgery, Jefferson Medical College, Wilmington, Delaware, USA

    Stephen P. Dunn

  2. Division of Gastroenterology, Seattle Children’s Hospital, Seattle, Washington, USA

    Simon Horslen

Section Editor information

  1. Nemours/Alfred I. duPont Hospital for Children, Wilmington, DE, USA

    Tetsu Uejima

Rights and permissions

Reprints and permissions

Copyright information

© 2018 Springer International Publishing AG, part of Springer Nature

About this entry

Check for updates. Verify currency and authenticity via CrossMark

Cite this entry

Salas, A., Slamon, N. (2018). Intensive Care of the Child After Kidney Transplantation. In: Dunn, S., Horslen, S. (eds) Solid Organ Transplantation in Infants and Children. Organ and Tissue Transplantation. Springer, Cham. https://doi.org/10.1007/978-3-319-07284-5_79

Download citation

  • DOI: https://doi.org/10.1007/978-3-319-07284-5_79

  • Published:

  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-07283-8

  • Online ISBN: 978-3-319-07284-5

  • eBook Packages: MedicineReference Module Medicine

Publish with us

Policies and ethics

Search

Navigation