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Allograft Dysfunction

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Solid Organ Transplantation in Infants and Children

Part of the book series: Organ and Tissue Transplantation ((OTT))

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Abstract

Lung transplantation is an established treatment option for children and adolescents suffering from end-stage lung diseases refractory to therapy. The primary aims, to prolong life and to improve quality of life, are reached in most cases. Improvements in surgical techniques and perioperative care have led to a relevant decrease of early mortality after lung transplantation, over the last two decades. Nevertheless, long-term survival remains significantly lower compared to other solid organ transplant outcomes. Chronic lung allograft dysfunction (CLAD) is the leading cause of death in lung transplant recipients after the first year from transplantation. Increasing knowledge of pathophysiological processes and risk factors for CLAD have emerged in recent years and new definitions of CLAD subtypes have been proposed. This chapter provides an overview of our current understanding of different forms of allograft dysfunction, their definition criteria and current treatment approaches.

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Author information

Authors and Affiliations

  1. Stanford University School of Medicine, Stanford, CA, USA

    Carol Conrad

  2. Klinik für Pädiatrische Pneumologie, Allergologie und Neonatologie, Medizinische Hochschule Hannover, Carl-Neuberg-Str. 1, 30625, Hannover, Germany

    Nicolaus Schwerk

Authors
  1. Carol Conrad
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  2. Nicolaus Schwerk
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Corresponding author

Correspondence to Carol Conrad .

Editor information

Editors and Affiliations

  1. Department of Surgery, Jefferson Medical College, Wilmington, Delaware, USA

    Stephen P. Dunn

  2. Division of Gastroenterology, Seattle Children’s Hospital, Seattle, Washington, USA

    Simon Horslen

Section Editor information

  1. The Children's Hospital of Philadelphia, Philadelphia, PA, USA

    Samuel B Goldfarb

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Conrad, C., Schwerk, N. (2018). Allograft Dysfunction. In: Dunn, S., Horslen, S. (eds) Solid Organ Transplantation in Infants and Children. Organ and Tissue Transplantation. Springer, Cham. https://doi.org/10.1007/978-3-319-07284-5_72

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  • DOI: https://doi.org/10.1007/978-3-319-07284-5_72

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-07283-8

  • Online ISBN: 978-3-319-07284-5

  • eBook Packages: MedicineReference Module Medicine

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