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Timing of Listing and Patient Management on the Waiting List

  • Gary Visner
  • Marc Schecter
  • Stuart Sweet
Reference work entry
Part of the Organ and Tissue Transplantation book series (OTT)

Abstract

Lung transplantation is considered for patients who have end-stage lung disease with no or limited therapeutic options and low probability of prolonged survival. There is limited information especially in children when to list for lung transplant and pretransplant management, and much of the level of evidence is based on expert opinion. In general, patients should be listed when lung transplantation is expected to improve survival. Ideally this is early enough for the transplant center to have time for adequate evaluation and take into consideration waitlist time. Factors that result in a high risk of a poor transplant outcomes are considered contraindications and may be disease and/or center dependent. Patient management should be directed to maintain survival while optimizing posttransplant outcomes.

Keywords

Lung Transplantation Children Waitlist Indications Contraindications 

References

  1. Aris RM, Routh JC, LiPuma JJ et al (2001) Lung transplantation for cystic fibrosis patients with Burkholderia cepacia complex. Survival linked to genomovar type. Am J Respir Crit Care Med 164:2102–2106CrossRefPubMedGoogle Scholar
  2. Benden C, Ridout DA, Edwards LB et al (2013) Body mass index and its effect on outcome in children after lung transplantation. J Heart Lung Transplant 32:196–201CrossRefPubMedGoogle Scholar
  3. Elizur A, Faro A, Huddleston CB et al (2009) Lung transplantation in infants and toddlers from 1990 to 2004 at St. Louis Children’s Hospital. Am J Transplant 9:719–726CrossRefPubMedGoogle Scholar
  4. Florian J, Rubin A, Mattiello R et al (2013) Impact of pulmonary rehabilitation on quality of life and functional capacity in patients on waiting lists for lung transplantation. J Bras Pneumol 39:349–356CrossRefPubMedPubMedCentralGoogle Scholar
  5. Garcia JP, Kon ZN, Evans C et al (2011) Ambulatory veno-venous extracorporeal membrane oxygenation: innovation and pitfalls. J Thorac Cardiovasc Surg 142:755–761CrossRefPubMedGoogle Scholar
  6. Gilljam M, Schersten H, Silverborn M et al (2010) Lung transplantation in patients with cystic fibrosis and mycobacterium abscessus infection. J Cyst Fibros 9:272–276CrossRefPubMedGoogle Scholar
  7. Gloeckl R, Halle M, Kenn K (2012) Interval versus continuous training in lung transplant candidates: a randomized trial. J Heart Lung Transplant 31:934–941CrossRefPubMedGoogle Scholar
  8. Goldfarb SB, Levvey BJ, Edwards LB et al (2016) The registry of the International Society for Heart and Lung Transplantation: nineteenth pediatric lung and heart-lung transplantation report-2016; focus theme: primary diagnostic indications for transplant. J Heart Lung Transplant 35:1196–1205CrossRefPubMedGoogle Scholar
  9. Grady RM, Gandhi SSC et al (2009) Dismal lung transplant outcomes in children with tetralogy of Fallot with pulmonary atresia compared to Eisenmenger syndrome or pulmonary vein stenosis. J Heart Lung Transplant 28:1221–1225CrossRefPubMedGoogle Scholar
  10. Hamvas A, Deterding R, Balch WE et al (2014) Diffuse lung disease in children: summary of a scientific conference. Pediatr Pulmonol 49:400–409CrossRefPubMedGoogle Scholar
  11. Hirche TO, Knoop C, Hebestreit H (2014) Practical guidelines: lung transplantation in patients with cystic fibrosis. Pulm Med 2014:621342CrossRefPubMedPubMedCentralGoogle Scholar
  12. Inci I, Klinzing S, Schneiter D (2015) Outcome of extracorporeal membrane oxygenation as a bridge to lung transplantation: an institutional experience and literature review. Transplantation 99:1667–1671CrossRefPubMedGoogle Scholar
  13. Langer D (2015) Rehabilitation in patients before and after lung transplantation. Respiration 89:353–362CrossRefPubMedGoogle Scholar
  14. Li M, Mathur S, Chowdhury NA et al (2013) Pulmonary rehabilitation in lung transplant candidates. J Heart Lung Transplant 32:626–632CrossRefPubMedGoogle Scholar
  15. Madill J, Gutierrez C, Grossman J et al (2001) Nutritional assessment of the lung transplant patient: body mass index as a predictor of 90-day mortality following transplantation. J Heart Lung Transplant 20:288–296CrossRefPubMedGoogle Scholar
  16. Mathur S, Reid WD, Levy RD (2004) Exercise limitation in recipients of lung transplants. Phys Ther 84:1178–1187PubMedGoogle Scholar
  17. Mathur S, Janaudis-Ferreira T, Wickerson L et al (2014) Meeting report: consensus recommendations for a research agenda in exercise in solid organ transplantation. Am J Transplant 14:2235–2245CrossRefPubMedGoogle Scholar
  18. Murray S, Charbeneau J, Marshall BC et al (2008) Impact of burkholderia infection on lung transplantation in cystic fibrosis. Am J Respir Crit Care Med 178:363–371CrossRefPubMedGoogle Scholar
  19. Pantoja JG, Andrade FH, Stoki DS et al (1999) Respiratory and limb muscle function in lung allograft recipients. Am J Respir Crit Care Med 160:1205–1211CrossRefPubMedGoogle Scholar
  20. Rehder KJ, Turner DA, Hartwig MG et al (2013) Active rehabilitation during extracorporeal membrane oxygenation as a bridge to lung transplantation. Respir Care 58:1291–1298CrossRefPubMedGoogle Scholar
  21. Reinsma GD, ten Hacken NH, Grevink RG et al (2006) Limiting factors of exercise performance 1 year after lung transplantation. J Heart Lung Transplant 25:1310–1316CrossRefPubMedGoogle Scholar
  22. Schakman O, Gilson H, Thissen JP (2008) Mechanisms of glucocorticoid-induced myopathy. J Endocrinol 197:1–10CrossRefPubMedGoogle Scholar
  23. Schakman O, Kalista S, Barbe C et al (2013) Glucocorticoid-induced skeletal muscle atrophy. Int J Biochem Cell Biol 45:2163–2172CrossRefPubMedGoogle Scholar
  24. Schwaiblmair M, Reichenspurner H, Muller C et al (1999) Cardiopulmonary exercise testing before and after lung and heart-lung transplantation. Am J Respir Crit Care Med 159:1277–1283CrossRefPubMedGoogle Scholar
  25. Stehlik J, Bavaria JE, Bax J et al (2016) Heart, lung, and vascular registries: evolving goals, successful approaches, and ongoing innovation. J Heart Lung Transplant 35:1149–1157CrossRefPubMedGoogle Scholar
  26. Taylor JL, Palmer SM (2006) Mycobacterium abscessus chest wall and pulmonary infection in a cystic fibrosis lung transplant recipient. J Heart Lung Transplant 25:985–988CrossRefPubMedGoogle Scholar
  27. Toprak D, Midyat L, Freiberger D et al (2017) Outcomes of mechanical support in a pediatric lung transplant center. Pediatr Pulmonol 52:360–366CrossRefPubMedGoogle Scholar
  28. Turner DA, Cheifetz IM, Rehder KJ et al (2011) Active rehabilitation and physical therapy during extracorporeal membrane oxygenation while awaiting lung transplantation: a practical approach. Crit Care Med 39:2593–2598CrossRefPubMedGoogle Scholar
  29. van Adrichem EJ, Reinsma GD, van den Berg S et al (2015) Predicting 6-minute walking distance in recipients of lung transplantation: longitudinal study of 108 patients. Phys Ther 95:720–729CrossRefPubMedGoogle Scholar
  30. Wambach JA, Casey AM, Fishman MP et al (2014) Genotype-phenotype correlations for infants and children with ABCA3 deficiency. Am J Respir Crit Care Med 189:1538–1543CrossRefPubMedPubMedCentralGoogle Scholar
  31. Weill D, Benden C, Corris PA et al (2015) A consensus document for the selection of lung transplant candidates: 2014--an update from the pulmonary transplantation Council of the International Society for heart and lung transplantation. J Heart Lung Transplant 34:1–15CrossRefPubMedGoogle Scholar

Copyright information

© Springer International Publishing AG, part of Springer Nature 2018

Authors and Affiliations

  1. 1.Division of Pulmonary MedicineBoston Children’s HospitalBostonUSA
  2. 2.Cincinnati Childrens HospitalCincinnatiUSA
  3. 3.Department of Pediatrics, Division of Pediatric Allergy, Immunology and Pulmonary MedicineWashington University School of MedicineSt. LouisUSA

Section editors and affiliations

  • Samuel B Goldfarb
    • 1
  1. 1.The Children's Hospital of PhiladelphiaPhiladelphiaUSA

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