Skip to main content
SpringerLink
Log in

Health-Related Quality of Life

  • Reference work entry
  • First Online:
Book cover Solid Organ Transplantation in Infants and Children

Part of the book series: Organ and Tissue Transplantation ((OTT))

  • 794 Accesses

Abstract

Patient survival after solid organ transplantation has improved dramatically over the last several decades. With better surgical techniques and an increased diversity in immunosuppressant medications, the length of survival after transplant is much improved. However with this improved survival, a new perspective on posttransplant quality of life is needed. Physical growth, developmental and psychosocial functioning, and health-related quality of life are all measures of long-term outcome that are becoming increasingly important in order to make the longer patient survival more meaningful and normal. This is especially difficult in a time of extreme physical, emotional, and psychosocial development and stress. It is important to take these factors into consideration when evaluating patients for solid organ transplantation. More prospective long-term studies need to be done to identify unknown factors that contribute to poor longitudinal growth, delayed physical and emotional development, and decreased health-related quality of life. Hopefully utilizing a more multidisciplinary approach, physicians and the healthcare team can assure better holistic outcomes for their patients.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 549.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Hardcover Book
USD 799.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  • Alonso EM (2008) Growth and developmental considerations in pediatric liver transplantation. Liver Transpl 14:585–591

    Article  PubMed  Google Scholar 

  • Alonso EM, Sorensen LG (2009) Cognitive development following pediatric solid organ transplantation. Curr Opin Organ Transplant 14:522–525

    Article  PubMed  Google Scholar 

  • Alonso EM, Limbers CA, Neighbors K et al (2010) Cross-sectional analysis of health related quality of life in pediatric liver transplant recipients. J Pediatr 156:270–276

    Article  PubMed  Google Scholar 

  • Anthony SJ, Hebert D, Todd L et al (2010) Child and parental perspectives of multidimensional quality of life outcomes after kidney transplantation. Pediatr Transplant 14:249–256

    Article  PubMed  Google Scholar 

  • Asonuma K, Inomata Y, Uemoto S et al (1998) Growth and quality of life after living-related liver transplantation in children. Pediatr Transplant 2:64–69

    CAS  PubMed  Google Scholar 

  • Baran M, Cakir M, Unal F et al (2011) Evaluation of growth after liver transplantation in Turkish children. Dig Dis Sci 56:3343–3349

    Article  PubMed  Google Scholar 

  • Broyer M, Le Bihan C, Charbit M (2004) Long-term social outcome of children after kidney transplantation. Transplantation 77:1033–1037

    Article  PubMed  Google Scholar 

  • Chinnock RE, Freier MC, Ashwal S et al (2008) Developmental outcomes after pediatric heart transplantation. J Heart Lung Transplant 27:1079–1084

    Article  PubMed  Google Scholar 

  • Cohen A, Addonizio LJ, Softness B et al (2004) Growth and skeletal maturation after pediatric cardiac transplantation. Pediatr Transplant 8:126–135

    Article  PubMed  Google Scholar 

  • Duffy JP, Kao K, Ko CY, Farmer DG et al (2010) Long-term patient outcome and quality of life after liver transplantation. Ann Surg 252:652–661

    PubMed  Google Scholar 

  • Elizur A, Faro A, Huddleston CB et al (2009) Lung transplantation in infants and toddlers from 1990 to 2004 at St Louis Children’s Hospital. Am J Transplant 9:719–726

    Article  CAS  PubMed  Google Scholar 

  • Falger J, Latal B, Landolt MA et al (2008) Outcome after renal transplantation part I: intellectual and motor performance. Pediatr Nephrol 23:1339–1345

    Article  PubMed  Google Scholar 

  • Franke D, Thomas L, Steffens R et al (2015) Patterns of growth after kidney transplantation among children with ESRD. Clin J Am Soc Nephrol 10:127–134

    Article  CAS  PubMed  Google Scholar 

  • Fredricks EM, Lopez MJ, Magee JC et al (2007) Psychological functioning, nonadherence and health outcomes after pediatric liver transplantation. Am J Transplant 7:1974–1983

    Article  Google Scholar 

  • Fredricks EM, Magee JC, Opipari-Arrigan L et al (2008) Adherence and health related quality of life in adolescent liver transplant recipients. Pediatr Transplant 12:289–299

    Article  Google Scholar 

  • Fredricks EM, Dore-Stites D, Calderon SY et al (2012) Relationship between sleep problems and health-related quality of life among pediatric liver transplant recipients. Liver Transpl 18:707–715

    Article  Google Scholar 

  • Freier MC, Babikan T, Pivonka J et al (2004) A longitudinal perspective on neurodevelopmental outcome after infant cardiac transplantation. J Heart Lung Transplant 23:857–864

    Article  PubMed  Google Scholar 

  • Gilmour S, Adkins R, Liddell GA et al (2009) Assessment of psychoeducational outcomes after pediatric liver transplant. Am J Transplant 9:294–300

    Article  CAS  PubMed  Google Scholar 

  • Gilmour SG, Sorensen LG, Anand R et al (2010) School outcomes in children registered in the Studies for Pediatric Liver Transplant (SPLIT) consortium. Liver Transpl 16:1041–1048

    Article  PubMed  PubMed Central  Google Scholar 

  • Green A, McSweeney J, Ainley K et al (2007) In my shoes: children’s quality of life after heart transplantation. Prog Transplant 17:199–207

    Article  PubMed  PubMed Central  Google Scholar 

  • Grenda R, Watson A, Trompeter R et al (2010) A randomized trial to assess the impact of early steroid withdrawal on growth in pediatric renal transplantation: the TWIST study. Am J Transplant 10:828–836

    Article  CAS  PubMed  Google Scholar 

  • Ikle L, Hale K, Fashaw L et al (2003) Developmental outcome of patients with hypoplastic left heart syndrome treated with heart transplantation. J Pediatr 142:20–25

    Article  PubMed  Google Scholar 

  • Johnson RJ, Warady BA (2013) Long-term neurocognitive outcomes of patients with end-stage renal disease during infancy. Pediatr Nephrol 28:1283–1291

    Article  PubMed  Google Scholar 

  • Kaller T, Schulz K, Sander K et al (2005) Cognitive abilities in children after liver transplantation. Transplantation 79:1252–1256

    Article  PubMed  Google Scholar 

  • Kaller T, Langguth N, Ganschow R et al (2010) Attention and executive functioning deficits in liver transplanted children transplantation. Transplantation 90:1567–1573

    Article  PubMed  Google Scholar 

  • Kaller T, Langguth N, Petermann F et al (2013) Cognitive performance in pediatric liver transplant recipients. Am J Transplant 13:2956–2965

    Article  CAS  PubMed  Google Scholar 

  • Karrfelt HME, Berg UB (2008) Long-term psychosocial outcome after renal transplantation during childhood. Pediatr Transplant 12:557–562

    Article  PubMed  Google Scholar 

  • Klare B, Montoya CR, Fischer D et al (2011) Normal adult height after steroid-withdrawal within 6 months of pediatric kidney transplantation: a 20 years single center experience. Transpl Int 25:276–282

    Article  PubMed  Google Scholar 

  • Kosola S, Lampela H, Laurnonen J (2011) General health, health-related quality of life and sexual health after pediatric liver transplantation: a nationwide study. Am J Transplant 12:420–427

    Article  PubMed  Google Scholar 

  • Lanuza DM, Lefaiver CA, McCabe M et al (2000) Prospective study of functional status and quality of life before and after lung transplantation. Chest 118:115–122

    Article  CAS  PubMed  Google Scholar 

  • Limbers CA, Neighbors K, Martz K et al (2011) Health related quality of life in pediatric liver transplant recipients compared with other chronic disease groups. Pediatr Transplant 15:245–253

    Article  PubMed  Google Scholar 

  • Lind RC, Sze Y-K, deVries W et al (2015) Achievement of developmental milestones in young adults after liver transplantation in childhood. Pediatr Transplant 19:287–293

    Article  PubMed  Google Scholar 

  • Mohammad A, Alonso EM (2010) Approach to optimizing growth, rehabilitation, and neurodevelopmental outcomes in children after sold-organ transplantation. Pediatr Clin N Am 57:539–557

    Article  Google Scholar 

  • Motoyama O, Kawamura T, Aikawa A et al (2009) Head circumference and development in young children after renal transplantation. Pediatr Int 51:71–74

    Article  PubMed  Google Scholar 

  • Myaskovsky L, Posluszny DM, Schulz R et al (2012) Predictors and outcomes of health-related quality of life in caregivers of cardiothoracic transplant recipients. Am J Transplant 12:3387–3397

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Newburger JW, Silbert AR, Buckley LP et al (1984) Cognitive function and age at repair of transposition of the great arteries in children. N Engl J Med 310:1495–1499

    Article  CAS  PubMed  Google Scholar 

  • Ng VL, Alonso EM, Bucuvalas JC et al (2012) Health status of children alive 10 years after pediatric liver transplantation performed in the US and Canada: report of the studies in pediatric liver transplantation experience. J Pediatr 160:820–826

    Article  PubMed  Google Scholar 

  • Ngo KD, Farmer DG, McDiarmid SV et al (2011) Pediatric health-related quality of life after intestinal transplantation. Pediatr Transplant 15:849–854

    Article  CAS  PubMed  Google Scholar 

  • North American Pediatric Renal Trials and Collaborative Studies (2014) Annual report 2014. Available at: https://web.emmes.com/study/ped/annlrept/annlrept.html. Accessed 12 Jul 2016

  • Nucci AM, Barksdale EM, Beserock N et al (2002) Long-term nutritional outcome after pediatric intestinal transplantation. J Pediatr Surg 37:460–463

    Article  PubMed  Google Scholar 

  • Perito ER, Glidden D, Roberts JP et al (2011) Overweight and obesity in pediatric liver transplant recipients: prevalence and predictors before and after transplant, United Network for Organ Sharing Data, 1987–2010. Pediatr Transplant 16:41–49

    Article  PubMed  PubMed Central  Google Scholar 

  • Peterson RE, Perens GS, Alejos JC et al (2008) Growth and weight gain of prepubertal children after cardiac transplantation. Pediatr Transplant 12:436–441

    Article  PubMed  Google Scholar 

  • Petroski RA, Grady KL, Rodgers E et al (2009) Quality of life in adult survivors greater than 10 years after pediatric heart transplantation. J Heart Lung Transplant 28:661–666

    Article  PubMed  Google Scholar 

  • Puustinen L, Janko H, Holmberg C et al (2005) Recombinant human growth hormone treatment after liver transplantation in childhood: the 5-year outcome. Transplantation 70:1241–1246

    Article  Google Scholar 

  • Qvist E, Jalanko H, Holmberg C (2003) Psychosocial adaptation after solid organ transplantation in children. Pediatr Clin N Am 50:1505–1519

    Article  Google Scholar 

  • Riano-Galan I, Malaga S, Rjmil L et al (2009) Quality of life of adolescents with end-stage renal disease and kidney transplant. Pediatr Nephrol 24:1561–1568

    Article  PubMed  Google Scholar 

  • Robertson CMT, Dinu IA, Joffe AR et al (2013) Neurocognitive outcomes at kindergarten entry after liver transplantation at <3 yr of age. Pediatr Transplant 17:621–630

    PubMed  Google Scholar 

  • Ross M, Kouretas P, Gamberg P et al (2006) Ten and 20-year survivors of pediatric orthotopic heart transplantation. J Heart Lung Transplant 25:261–270

    Article  PubMed  Google Scholar 

  • Sarna S, Laine J, Sipila I et al (1995) Differences in linear growth and cortisol production between liver and renal transplant recipients on similar immunosuppression. Transplantation 60:656–661

    Article  CAS  PubMed  Google Scholar 

  • Scheenstra R, Gerver WJ, Odink RJ et al (2008) Growth and final height after liver transplantation during childhood. J Pediatr Gastroenterol Nutr 47:165–171

    Article  PubMed  Google Scholar 

  • Smeritschnig B, Jaksch P, Kocher A et al (2005) Quality of life after lung transplantation: a cross-sectional study. J Heart Lung Transplant 24:474–480

    Article  PubMed  Google Scholar 

  • Sorensen LG, Neighbors K, Martz K et al (2011) Cognitive and academic outcomes after pediatric liver transplantation: functional outcomes group (FOG) results. Am J Transplant 11:303–311

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Sorensen LG, Neighbors K, Martz K et al (2014) Longitudinal study of cognitive and academic outcomes after pediatric liver transplantation. J Pediatr 165:65–72

    Article  PubMed  PubMed Central  Google Scholar 

  • Sudan DL, Iverson A, Weserman RA et al (2000) Assessment of function, growth and development, and long-term quality of life after small bowel transplantation. Transplant Proc 32:1211–1212

    Article  CAS  PubMed  Google Scholar 

  • Sundaram SS, Landgraf JM, Neighbors K et al (2007) Adolescent health-related quality of life following liver and kidney transplantation. Am J Transplant 7:982–989

    Article  CAS  PubMed  Google Scholar 

  • Sweet SC, Spray TL, Huddleston CB et al (1997) Pediatric lung transplantation at St Louis Children’s Hospital, 1990–1995. Am J Respir Crit Care Med 155:1027–1035

    Article  CAS  PubMed  Google Scholar 

  • Thevenin DM, Baker A, Kato T et al (2006) Neurodevelopmental outcomes of infant multivisceral transplant recipients: a longitudinal study. Transplant Proc 28:1694–1695

    Article  Google Scholar 

  • Wray J, Radley-Smith R (2005) Beyond the first year after pediatric heart or heart-lung transplantation: changes in cognitive function and behavior. Pediatr Transplant 9:170–177

    Article  PubMed  Google Scholar 

  • Wu Y, Cheng W, Yang X-D et al (2013) Growth hormone improves growth in pediatric renal transplant recipients – a systemic review and meta-analysis of randomized controlled trials. Pediatr Nephrol 28:129–133

    Article  CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Sidney Kimmel Medical College at Thomas Jefferson University, Philadelphia, PA, USA

    Catherine Marie Soprano

  2. Diagnostic Referral Division, Department of Pediatrics, Nemours/A.I. DuPont Hospital for Children, Wilmington, DE, USA

    Catherine Marie Soprano

Authors
  1. Catherine Marie Soprano
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Catherine Marie Soprano .

Editor information

Editors and Affiliations

  1. Department of Surgery, Jefferson Medical College, Wilmington, Delaware, USA

    Stephen P. Dunn

  2. Division of Gastroenterology, Seattle Children’s Hospital, Seattle, Washington, USA

    Simon Horslen

Section Editor information

  1. Nemours/Alfred I. duPont Hospital for Children, Wilmington, DE, USA

    Deborah M Consolini

Rights and permissions

Reprints and permissions

Copyright information

© 2018 Springer International Publishing AG, part of Springer Nature

About this entry

Check for updates. Verify currency and authenticity via CrossMark

Cite this entry

Soprano, C.M. (2018). Health-Related Quality of Life. In: Dunn, S., Horslen, S. (eds) Solid Organ Transplantation in Infants and Children. Organ and Tissue Transplantation. Springer, Cham. https://doi.org/10.1007/978-3-319-07284-5_50

Download citation

  • DOI: https://doi.org/10.1007/978-3-319-07284-5_50

  • Published:

  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-07283-8

  • Online ISBN: 978-3-319-07284-5

  • eBook Packages: MedicineReference Module Medicine

Publish with us

Policies and ethics

Search

Navigation