Pediatric Nephrologist and the Infant or Child Before Kidney Transplantation
Renal transplantation is the standard of care for the management of pediatric end-stage renal disease. Many infants, children, and adolescents require dialysis prior to transplant, and due to this therapeutic modality, transplant is considered elective. However, significant short-term and long-term morbidities are associated with dialysis, especially when necessary for prolonged periods. For this reason, preemptive renal transplant is desirable when it can be planned. Most chronic kidney disease and end-stage renal disease in pediatrics is due to congenital structural abnormalities, although the predominant causes of renal disease vary by age, geography, and ethnicity. A substantial proportion of pediatric renal disease has a known genetic cause. Effective management of chronic kidney disease, specifically its complications, can have a significant impact on outcomes and potentially delay the onset of end-stage renal disease.
KeywordsEnd-stage renal disease Chronic kidney disease Renal replacement therapy Hemodialysis Peritoneal dialysis Hypertension Growth hormone Glomerular filtration rate Congenital abnormalities of the kidney and urinary tract Next-generation sequencing Steroid-resistant nephrotic syndrome Focal segmental glomerulosclerosis Glomerulonephritis Mineral and bone disease Angiotensin-converting enzyme inihibitor Angiotensin receptor blocker
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